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Polymerase (DNA Directed), beta (POLB) (N-Term) antibody

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Synonyms wu:fa97a05, zgc:109924, POLB, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, A430088C08Rik
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(13), (11), (5), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(84), (50), (41), (4), (2), (2), (2)
(63), (32)
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(74), (35), (24), (15), (12), (11), (8), (1)
Pubmed 9 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human POLB (DNA polymerase beta)
Alternative Name POLB (POLB Antibody Abstract)
Background POLB (DNA polymerase beta) is a repair polymerase. POLB conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. POLB has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. POLB binds 2 magnesium ions per subunit (By similarity).POLB belongs to the DNA polymerase type-X family.
Pathways DNA Damage Repair
Restrictions For Research Use only
Product cited in: El-Andaloussi, Valovka, Toueille et al.: "Arginine methylation regulates DNA polymerase beta." in: Molecular cell, Vol. 22, Issue 1, pp. 51-62, 2006 (PubMed).

DeMott, Beyret, Wong et al.: "Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone." in: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 7637-40, 2002 (PubMed).

Patterson, Little, Cheng et al.: "Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes." in: Protein expression and purification, Vol. 18, Issue 1, pp. 100-10, 2000 (PubMed).

Matsumoto, Kim, Katz et al.: "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups." in: Biochemistry, Vol. 37, Issue 18, pp. 6456-64, 1998 (PubMed).

Chyan, Ackerman, Shepherd et al.: "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression." in: Nucleic acids research, Vol. 22, Issue 14, pp. 2719-25, 1994 (PubMed).

Dobashi, Kubota, Shuin et al.: "Polymorphisms in the human DNA polymerase beta gene." in: Human genetics, Vol. 95, Issue 4, pp. 389-90, 1995 (PubMed).

Abbotts, SenGupta, Zmudzka et al.: "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme." in: Biochemistry, Vol. 27, Issue 3, pp. 901-9, 1988 (PubMed).

Widen, Kedar, Wilson: "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter." in: The Journal of biological chemistry, Vol. 263, Issue 32, pp. 16992-8, 1988 (PubMed).

SenGupta, Zmudzka, Kumar et al.: "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning." in: Biochemical and biophysical research communications, Vol. 136, Issue 1, pp. 341-7, 1986 (PubMed).

Catalog No. ABIN966877
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