Polymerase (DNA Directed), beta (POLB) (N-Term), (2meArg152) antibody

Details for Product No. ABIN966878
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Antigen
Synonyms wu:fa97a05, zgc:109924, POLB, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, A430088C08Rik
Epitope
N-Term, 2meArg152
(9), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(66), (47), (37), (14), (12), (12), (12), (1), (1)
Host
Rabbit
(48), (31)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(64), (24), (21), (16), (14), (10), (3), (3), (1)
Pubmed 9 references available
Quantity 0.1 mg
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Catalog No. ABIN966878
466.13 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human POLB (DNA polymerase beta)
Alternative Name POLB
Background POLB (DNA polymerase beta) is a repair polymerase. POLB conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. POLB has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. POLB binds 2 magnesium ions per subunit (By similarity).POLB belongs to the DNA polymerase type-X family.
Restrictions For Research Use only
Product cited in: SenGupta, Zmudzka, Kumar et al.: "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning." in: Biochemical and biophysical research communications, Vol. 136, Issue 1, pp. 341-7, 1986 (PubMed).

Widen, Kedar, Wilson: "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter." in: The Journal of biological chemistry, Vol. 263, Issue 32, pp. 16992-8, 1988 (PubMed).

Abbotts, SenGupta, Zmudzka et al.: "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme." in: Biochemistry, Vol. 27, Issue 3, pp. 901-9, 1988 (PubMed).

Dobashi, Kubota, Shuin et al.: "Polymorphisms in the human DNA polymerase beta gene." in: Human genetics, Vol. 95, Issue 4, pp. 389-90, 1995 (PubMed).

Chyan, Ackerman, Shepherd et al.: "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression." in: Nucleic acids research, Vol. 22, Issue 14, pp. 2719-25, 1994 (PubMed).

Matsumoto, Kim, Katz et al.: "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups." in: Biochemistry, Vol. 37, Issue 18, pp. 6456-64, 1998 (PubMed).

Patterson, Little, Cheng et al.: "Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes." in: Protein expression and purification, Vol. 18, Issue 1, pp. 100-10, 2000 (PubMed).

DeMott, Beyret, Wong et al.: "Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone." in: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 7637-40, 2002 (PubMed).

El-Andaloussi, Valovka, Toueille et al.: "Arginine methylation regulates DNA polymerase beta." in: Molecular cell, Vol. 22, Issue 1, pp. 51-62, 2006 (PubMed).

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