SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase (SHPRH) (N-Term) antibody

Details for Product No. ABIN967027
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Antigen
Synonyms 2610103K11Rik, AA450458, AU024614, BC006883, D230017O13Rik, E130018M05, bA545I5.2
Epitope
N-Term
(7), (5), (4), (1), (1)
Reactivity
Human
(49), (17), (13), (12), (12), (12)
Host
Rabbit
(29), (24)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(41), (10), (5), (3), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN967027
466.13 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human SHPRH (E3 ubiquitin-protein ligase SHPRH )
Alternative Name SHPRH
Background SHPRH (E3 ubiquitin-protein ligase SHPRH ) involved in DNA repair. Upon genotoxic stress, SHPRH accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of noncanonical poly-ubiquitin chains linked through 'Lys-63'. SHPRH interacts with HLTF, PCNA, UBE2N and RAD18. The RING finger mediates E3 ubiquitin ligase activity. SHPRH belongs to the SNF2/RAD54 helicase family. SHPRH contains 1 helicase ATP-binding domain, 1 helicase C-terminal domain, 1 histone H1 domain, 1 PHD-type zinc finger and 1 RING-type zinc finger.
Synonyms: KIAA2023, SNF2, histone-linker, PHD and RING finger domain-containing helicase.
Research Area Cancer, Cell Cycle, Proteolysis / Ubiquitin
Restrictions For Research Use only
Product cited in: Motegi, Liaw, Lee et al.: "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 34, pp. 12411-6, 2008 (PubMed).

Motegi, Sood, Moinova et al.: "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination." in: The Journal of cell biology, Vol. 175, Issue 5, pp. 703-8, 2006 (PubMed).

Unk, Hajdú, Fátyol et al.: "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 48, pp. 18107-12, 2006 (PubMed).

Sood, Makalowska, Galdzicki et al.: "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region." in: Genomics, Vol. 82, Issue 2, pp. 153-61, 2003 (PubMed).

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