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SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase (SHPRH) (N-Term) antibody

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Synonyms 2610103K11Rik, AA450458, AU024614, BC006883, D230017O13Rik, E130018M05, bA545I5.2
(18), (6), (5), (5), (2), (1), (1)
(57), (21), (14)
(34), (30)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(50), (11), (6), (3), (3), (3), (2)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human SHPRH (E3 ubiquitin-protein ligase SHPRH )
Alternative Name SHPRH (SHPRH Antibody Abstract)
Background SHPRH (E3 ubiquitin-protein ligase SHPRH ) involved in DNA repair. Upon genotoxic stress, SHPRH accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of noncanonical poly-ubiquitin chains linked through 'Lys-63'. SHPRH interacts with HLTF, PCNA, UBE2N and RAD18. The RING finger mediates E3 ubiquitin ligase activity. SHPRH belongs to the SNF2/RAD54 helicase family. SHPRH contains 1 helicase ATP-binding domain, 1 helicase C-terminal domain, 1 histone H1 domain, 1 PHD-type zinc finger and 1 RING-type zinc finger.
Synonyms: KIAA2023, SNF2, histone-linker, PHD and RING finger domain-containing helicase.
Research Area Cancer, Cell Cycle, Proteolysis / Ubiquitin
Restrictions For Research Use only
Product cited in: Motegi, Liaw, Lee et al.: "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 34, pp. 12411-6, 2008 (PubMed).

Motegi, Sood, Moinova et al.: "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination." in: The Journal of cell biology, Vol. 175, Issue 5, pp. 703-8, 2006 (PubMed).

Sood, Makalowska, Galdzicki et al.: "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region." in: Genomics, Vol. 82, Issue 2, pp. 153-61, 2003 (PubMed).

Background publications Unk, Hajdú, Fátyol et al.: "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 48, pp. 18107-12, 2006 (PubMed).

Catalog No. ABIN967027
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