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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) antibody

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Synonyms zgc:73312, MGC81443, homolog of human DNA ligase iv-binding protein XRCC4, 2310057B22Rik, AW413319, AW545101
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(101), (21), (20), (1)
(89), (12)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(83), (24), (22), (13), (11), (11), (9), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human XRCC4(X-ray repair cross-complementing protein 4)
Alternative Name XRCC4 (XRCC4 Antibody Abstract)
Background XRCC4 (X-ray repair cross-complementing protein 4) is involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. XRCC4 binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. XRCC4 is a homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (G22P1/G22P2) and PRKDC. XRCC4 seems to interact directly with PRKDC but not with the Ku p70/86 dimer. It interacts with XLF/Cernunnos. Interacts with APTX and APLF. Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. It has no effect on ubiquitination.
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Pathways DNA Damage Repair
Restrictions For Research Use only
Product cited in: Nick McElhinny, Snowden, McCarville et al.: "Ku recruits the XRCC4-ligase IV complex to DNA ends." in: Molecular and cellular biology, Vol. 20, Issue 9, pp. 2996-3003, 2000 (PubMed).

Leber, Wise, Mizuta et al.: "The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1794-801, 1998 (PubMed).

Grawunder, Wilm, Wu et al.: "Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells." in: Nature, Vol. 388, Issue 6641, pp. 492-5, 1997 (PubMed).

Background publications Chen, Trujillo, Sung et al.: "Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 275, Issue 34, pp. 26196-205, 2000 (PubMed).

Li, Otevrel, Gao et al.: "The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination." in: Cell, Vol. 83, Issue 7, pp. 1079-89, 1996 (PubMed).

Catalog No. ABIN967264
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