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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) (C-Term), (sumoLys210) antibody

Details for Product No. ABIN967265
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Antigen
Synonyms zgc:73312, MGC81443, homolog of human DNA ligase iv-binding protein XRCC4, 2310057B22Rik, AW413319, AW545101
Epitope
C-Term, sumoLys210
(7), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(67), (19), (17), (13), (12), (12)
Host
Rabbit
(61), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(57), (18), (11), (10), (10), (6), (4), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN967265
452.38 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human XRCC4(X-ray repair cross-complementing protein 4)
Note: Antigen containing K210 amino group with the SUMO1 c-terminal 7-mer peptide bound: YQEQTGG
Alternative Name XRCC4
Background XRCC4 (X-ray repair cross-complementing protein 4) is involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. XRCC4 binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. XRCC4 is a homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (G22P1/G22P2) and PRKDC. XRCC4 seems to interact directly with PRKDC but not with the Ku p70/86 dimer. It interacts with XLF/Cernunnos. Interacts with APTX and APLF. Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. It has no effect on ubiquitination.
Restrictions For Research Use only
Product cited in: Li, Otevrel, Gao et al.: "The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination." in: Cell, Vol. 83, Issue 7, pp. 1079-89, 1996 (PubMed).

Grawunder, Wilm, Wu et al.: "Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells." in: Nature, Vol. 388, Issue 6641, pp. 492-5, 1997 (PubMed).

Leber, Wise, Mizuta et al.: "The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1794-801, 1998 (PubMed).

Nick McElhinny, Snowden, McCarville et al.: "Ku recruits the XRCC4-ligase IV complex to DNA ends." in: Molecular and cellular biology, Vol. 20, Issue 9, pp. 2996-3003, 2000 (PubMed).

Chen, Trujillo, Sung et al.: "Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 275, Issue 34, pp. 26196-205, 2000 (PubMed).

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