Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (Tyr125) antibody

Details for Product No. ABIN967584
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Antigen
Synonyms NACP, alphaSYN, PARK1, PARK4, PD1
Epitope
Tyr125
(40), (34), (27), (25), (25), (14), (12), (10), (7), (7), (7), (6), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(384), (165), (141), (92), (89), (78), (24), (24), (3), (1), (1)
Host
Mouse
(281), (95), (15), (10), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (11), (11), (8), (8), (8), (8), (8), (8), (8), (8)
Application
Western Blotting (WB)
(268), (114), (83), (80), (74), (67), (29), (22), (16), (6), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN967584
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Immunogen Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of alpha-Synuclein
Clone I57-628
Isotype IgG2b, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name alpha Synuclein
Background The 140-amino-acid alpha-Synuclein protein is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). This protein is expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. The Tyrosine 125 (Y125) residue of alpha-Synuclein plays an important role in stress-induced dimerization of the protein and is phosphorylated by Pyk/RAFTK via the Src-family kinases Fyn and c-Src.
The I57-628 antibody recognizes alpha-Synuclein phosphorylated at Y125.
Molecular Weight 19 kDa
Research Area Neurology, Alzheimer's Disease
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (Tyr125) antibody Western blot analysis of alpha-Synuclein (pY125). Lysates from control (first panel) and pervanadate-treated (second panel) HEK 293 cells were probed with mAb I57-628 at concentrations of 0.002, 0.001, and 0.0005 µg/ml (Lanes 1, 2, and 3, respectively). alpha-Synuclein (pY125) is identified as a strong band of 19 kDa in the pervanadate-treated cells.
Product cited in: Ellis, Schwartzberg, Grider et al.: "alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases." in: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 3879-84, 2001 (PubMed).

Nakamura, Yamashita, Takahashi et al.: "Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125." in: Biochemical and biophysical research communications, Vol. 280, Issue 4, pp. 1085-92, 2001 (PubMed).

Takahashi, Yamashita, Nakamura et al.: "Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress." in: Brain research, Vol. 938, Issue 1-2, pp. 73-80, 2002 (PubMed).

Nakamura, Yamashita, Nagano et al.: "Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases." in: FEBS letters, Vol. 521, Issue 1-3, pp. 190-4, 2002 (PubMed).

Forman, Trojanowski, Lee: "Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs." in: Nature medicine, Vol. 10, Issue 10, pp. 1055-63, 2004 (PubMed).

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