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SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

Antigen

SRY (Sex Determining Region Y)-Box 2 (SOX2)
Synonyms ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2
Clonality Monoclonal (O30-678)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Intracellular Flow Cytometry (ICFC), BioImaging (BI), Immunofluorescence (IF)
3 references available
Catalog no. ABIN967676
Quantity 0.1 mg  (0.5 mg/ml)
Price Product not available in this region.
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anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody (2)

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name SOX2
Gene ID 6657, 20674
Immunogen Human Sox2 Recombinant Protein
Cross-Reactivity Mouse (Murine)
Format Liquid
Isotype IgG1, kappa
Clone O30-678
Description The monoclonal antibody O30-678 recognizes the Sox2 transcription factor. Sox2 [SRY (sex determining region Y)-box 2] is a member of the SRY-related HMG-box (SOX) family of transcription factors. Sox2 is required for the maintenance of the undifferentiated state of pluripotent stem cells. Complexes of Sox2 with the homeobox transcription factors Oct3/4 and/or Nanog bind to the promoters of a network of genes that are involved in the maintenance of pluripotency and self renewal in stem cells. Sox2 is also a marker of neural stem cells during embryonic development and in the adult brain. The O30-678 antibody recognizes both human and mouse Sox2 proteins.
Characteristics 1. Please refer to us for technical protocols.
2. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. mTESR™1 is a trademark of StemCell Technologies.
5. Triton is a trademark of the Dow Chemical Company.
6. Alexa Fluor® is a registered trademark of Life Technologies Corporation.
Molecular Weight 36 kDa
Comments

Related Products: ABIN967389

Application Details
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Concentration 0.5 mg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution.
Preservative 0.09% Sodium azide.
Storage Store undiluted at 4°C.
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Restrictions For Research Use only

Publications
Application Details Images Alternatives back to top

Product Boyer, Lee, Cole et al.: "Core transcriptional regulatory circuitry in human embryonic stem cells." in: Cell, Vol. 122, Issue 6, pp. 947-56, 2005 (PubMed).

Takahashi, Yamanaka: "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors." in: Cell, Vol. 126, Issue 4, pp. 663-76, 2006 (PubMed).

Pan, Thomson: "Nanog and transcriptional networks in embryonic stem cell pluripotency." in: Cell research, Vol. 17, Issue 1, pp. 42-9, 2007 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts Rabbit (90), Mouse (19), Goat (4)
Reactivities Human (108), Mouse (Murine) (41), Rat (Rattus) (32), Dog (Canine) (23), Pig (Porcine) (23), Chicken (22), Cow (Bovine) (22), Sheep (Ovine) (20), Guinea Pig (18), Xenopus laevis (2), Zebrafish (2), Zebrafish (Danio rerio) (2), Cat (Feline) (1), Chimpanzee (1), Monkey (1), Opossum (Didelphimorphia) (1), Rhesus Monkey (1), Salmon (Salmonidae) (1)
Applications Western Blotting (WB) (78), ELISA (57), Immunofluorescence (IF) (33), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Immunohistochemistry (IHC) (14), Immunocytochemistry (ICC) (10), Dot Blot (Dot) (6), Flow Cytometry (FACS) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes N-Term (9), C-Term (3), AA 1-170 (2), Ala30 (2), Cys265 (2), Internal Region (2), AA 50-100 (1), C-Term, AA 240-260 (1), Center (1), pSer246 (1), pSer249 (1), pSer250 (1), pSer251 (1), pSer83 (1), pTyr108 (1)