SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

Details for Product No. ABIN967676
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Antigen
Synonyms Qscn6, Qsox, Sox-2, rSOx, ANOP3, MCOPS3, RGD1565646, SRY-box2, Xsox-2, anop3, mcops3, sox-2, lcc, ysb, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389
Reactivity
Human
(245), (61), (41), (9), (8), (8), (5), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1)
Host
Mouse
(203), (49), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(14), (13), (12), (12), (10), (10), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Intracellular Flow Cytometry (ICFC), BioImaging (BI), Immunofluorescence (IF)
(183), (104), (52), (45), (43), (38), (33), (29), (18), (10), (7), (5), (5), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Options
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Immunogen Human Sox2 Recombinant Protein
Clone O30-678
Isotype IgG1, kappa
Cross-Reactivity Mouse (Murine)
Characteristics 1. Please refer to us for technical protocols.
2. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. mTESR™1 is a trademark of StemCell Technologies.
5. Triton is a trademark of the Dow Chemical Company.
6. Alexa Fluor® is a registered trademark of Life Technologies Corporation.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SOX2 (SOX2 Antibody Abstract)
Background The monoclonal antibody O30-678 recognizes the Sox2 transcription factor. Sox2 [SRY (sex determining region Y)-box 2] is a member of the SRY-related HMG-box (SOX) family of transcription factors. Sox2 is required for the maintenance of the undifferentiated state of pluripotent stem cells. Complexes of Sox2 with the homeobox transcription factors Oct3/4 and/or Nanog bind to the promoters of a network of genes that are involved in the maintenance of pluripotency and self renewal in stem cells. Sox2 is also a marker of neural stem cells during embryonic development and in the adult brain. The O30-678 antibody recognizes both human and mouse Sox2 proteins.
Molecular Weight 36 kDa
Gene ID 6657, 20674
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody Western Blot analysis of Sox2 in Human Neural Stem Cells (NSC) and Mouse Embryonic St...
anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody (2) Immunoflourescent staining of Sox2 in human embryonic stem (ES) cells. H9 human ES ce...
Product cited in: Pan, Thomson: "Nanog and transcriptional networks in embryonic stem cell pluripotency." in: Cell research, Vol. 17, Issue 1, pp. 42-9, 2007 (PubMed).

Takahashi, Yamanaka: "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors." in: Cell, Vol. 126, Issue 4, pp. 663-76, 2006 (PubMed).

Boyer, Lee, Cole et al.: "Core transcriptional regulatory circuitry in human embryonic stem cells." in: Cell, Vol. 122, Issue 6, pp. 947-56, 2005 (PubMed).

Validation Images
Catalog No. ABIN967676
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