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RAN, Member RAS Oncogene Family (RAN) (AA 7-171) antibody

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Synonyms ara24, gsp1, ran-1, tc4, RAN, xran, AAF30287, CG1404, Dmel\CG1404, Ran, dran, l(1)G0075, ran10A, ran, ARA24, Gsp1, TC4, RANP1, M2, Ran/M2, Rasl2-9-ps, fc16b04, wu:fc16b04
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AA 7-171
(22), (20), (15), (14), (10), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(146), (78), (66), (13), (9), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1)
(110), (32), (6)
Clonality (Clone)
Monoclonal ()
(6), (6), (6), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(115), (68), (43), (24), (22), (19), (15), (15), (9), (4), (2), (1)
Pubmed 5 references available
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Quantity 150 μg
Shipping to United States ( )
Immunogen Human Ran aa. 7-171
Clone 20-Ran
Isotype IgG2a
Cross-Reactivity Chicken, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Ran (RAN Antibody Abstract)
Background Ran is a highly conserved GTPase that is ubiquitously expressed. At steady-state, 80-90% of cellular Ran is located in the nucleus, with the remainder in the cytoplasm. The human TC4/Ran cDNA was originally isolated based on the predicted homology of its encoded protein product to Ras. Unlike other members of the Ras superfamily, Ran does not appear to contain signals for lipid modification, nor does it appear to show membrane localization. Ran has been implicated in a number of cellular processes such as the initiation of DNA replication, entry into and exit from mitosis and in nuclear RNA and protein transport through the nuclear pore complex. A number of Ran binding proteins have been identified. One of the smaller proteins identified is a 28kDa cytosolic molecule known as RanBP1. The GTP-bound state of Ran is stabilized through its binding to RanBP1.
Molecular Weight 25 kDa
Research Area Chromatin and Nuclear Signaling
Pathways Regulatory RNA Pathways

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-RAN, Member RAS Oncogene Family (RAN) (AA 7-171) antibody (ABIN967913) Western blot analysis of Ran on A431 cell lysate. Lane 1: 1:5000, lane 2: 1:10000, la...
Immunofluorescence (IF) image for anti-RAN, Member RAS Oncogene Family (RAN) (AA 7-171) antibody (ABIN967913) Immunofluorescent staining of HeLa cells.
 image for anti-RAN, Member RAS Oncogene Family (RAN) (AA 7-171) antibody (ABIN967913) anti-RAN, Member RAS Oncogene Family (RAN) (AA 7-171) antibody (Image 3)
Western Blotting (WB) image for anti-RAN, Member RAS Oncogene Family (RAN) (AA 7-171) antibody (ABIN967913) anti-RAN, Member RAS Oncogene Family (RAN) (AA 7-171) antibody (Image 4)
Product cited in: Schwoebel, Ho, Moore: "The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion." in: The Journal of cell biology, Vol. 157, Issue 6, pp. 963-74, 2002 (PubMed).

Nemergut, Lindsay, Brownawell et al.: "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor." in: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 17385-8, 2002 (PubMed).

Faleiro, Lazebnik: "Caspases disrupt the nuclear-cytoplasmic barrier." in: The Journal of cell biology, Vol. 151, Issue 5, pp. 951-9, 2000 (PubMed).

Iborra, Jackson, Cook: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." in: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, 2000 (PubMed).

Drivas, Shih, Coutavas et al.: "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line." in: Molecular and cellular biology, Vol. 10, Issue 4, pp. 1793-8, 1990 (PubMed).

Catalog No. ABIN967913
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