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RAN Products

(RAN, Member RAS Oncogene Family (RAN))

Categories

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008].

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Featured RAN Categories

RAN Antibodies

High quality antibodies with extensive validation data.

RAN Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RAN Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (10)
Cat. No. ABIN5542382
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (6)
Cat. No. ABIN5518950
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application FACS, IHC, ELISA, WB
Validations
  • (6)
Cat. No. ABIN3032431
Quantity 0.4 mL
Datasheet Datasheet

Recommended RAN ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6207291
Quantity 96 tests
Datasheet Datasheet

Recommended RAN Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3086828
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3120789
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317375
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our RAN products

Zhang, Yang, Cao, Xu, Li, Chen, Gao, Xin, Zhou, Zhou, Yang, Sheng, Zeng: "MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer." in: Cancer letters, Vol. 342, Issue 1, pp. 121-9, (2013) (PubMed).

Xia, Dohi, Martin, Raskett, Liu, Altieri: "Essential role of the small GTPase Ran in postnatal pancreatic islet development." in: PLoS ONE, Vol. 6, Issue 11, pp. e27879, (2011) (PubMed).

Ly, Wang, Pereira, Rojas, Peng, Feng, Cerione, Wilson: "Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5815-26, (2010) (PubMed).

Simula, Cannizzaro, Canzonieri, Pavan, Maiero, Toffoli, De Re: "PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 5-6, pp. 199-209, (2010) (PubMed).

Nilsen, Rosendal, Sørensen, Wesche, Olsnes, Wiedłocha: "A nuclear export sequence located on a beta-strand in fibroblast growth factor-1." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26245-56, (2007) (PubMed).

Ramos, Rafikova, Melikov, Chernomordik: "Transmembrane proteins are not required for early stages of nuclear envelope assembly." in: The Biochemical journal, Vol. 400, Issue 3, pp. 393-400, (2006) (PubMed).

Nemergut, Lindsay, Brownawell, Macara: "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor." in: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 17385-8, (2002) (PubMed).

Schwoebel, Ho, Moore: "The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion." in: The Journal of cell biology, Vol. 157, Issue 6, pp. 963-74, (2002) (PubMed).

Faleiro, Lazebnik: "Caspases disrupt the nuclear-cytoplasmic barrier." in: The Journal of cell biology, Vol. 151, Issue 5, pp. 951-9, (2000) (PubMed).

Iborra, Jackson, Cook: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." in: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, (2000) (PubMed).

Synonyms and alternative names related to RAN

RAN, member RAS oncogene family (RAN), RAN, member RAS oncogene family (Ran), RAN, member RAS oncogene family S homeolog (ran.S), RAN, member RAS oncogene family (ran), CG1404 gene product from transcript CG1404-RC (Ran), AAF30287, ARA24, ara24, CG1404, Dmel\CG1404, dran, fc16b04, Gsp1, gsp1, l(1)G0075, ran, RAN, Ran, ran-1, ran10A, RANP1, TC4, tc4, wu:fc16b04

Protein level used designations for RAN

  • GTP-binding nuclear protein Ran
  • GTPase Ran
  • OK/SW-cl.81
  • RanGTPase
  • androgen receptor-associated protein 24
  • guanosine triphosphatase Ran
  • member RAS oncogene family
  • ras-like protein TC4
  • ras-related nuclear protein
  • RAN, member RAS oncogene family
  • RAN, member RAS oncogene family pseudogene 1
  • CG1404-PA
  • CG1404-PB
  • Ran GTPase
  • ran-PA
  • ran-PB
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