You are viewing an incomplete version of our website. Please click to reload the website as full version.

FADD antibody (Fas (TNFRSF6)-Associated Via Death Domain) (AA 94-208)

Details for Product anti-FADD Antibody No. ABIN967945, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms MORT1, Mort1/FADD, Mort1, TNFRSF6
AA 94-208
(29), (26), (22), (18), (13), (11), (10), (9), (8), (7), (6), (6), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(169), (72), (32), (6), (3), (3), (1)
(178), (48)
Clonality (Clone)
Monoclonal ()
This FADD antibody is un-conjugated
(8), (7), (6), (4), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(188), (104), (71), (22), (22), (15), (14), (9), (5), (5), (4), (2), (1), (1), (1)
Pubmed 5 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 150 μg
Shipping to United States ( )
Immunogen Human FADD aa. 94-208
Clone 1-FADD
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name FADD (FADD Antibody Abstract)
Background During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation. The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized. The tumor necrosis factor receptor (TNF-R) can trigger cell death, as well as various other responses. Data suggested that Fas and TNF-R affect a common target in the cell death pathway. This target has been identified as FADD, a novel protein that contains a death domain homologous to the death domains of Fas and TNF-R1. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that is inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death. Thus, FADD is a central element of the Fas-mediated cell death pathway. This antibody is routinely tested by western blot analysis.
Molecular Weight 24 kDa
Research Area Cancer, Apoptosis/Necrosis
Pathways Apoptosis, TLR Signaling

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-FADD antibody (Fas (TNFRSF6)-Associated Via Death Domain) (AA 94-208) (ABIN967945) Western blot analysis of FADD on a A431 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3:...
 image for anti-FADD antibody (Fas (TNFRSF6)-Associated Via Death Domain) (AA 94-208) (ABIN967945) Immunoflourescence staining of MDCK cells.
 image for anti-FADD antibody (Fas (TNFRSF6)-Associated Via Death Domain) (AA 94-208) (ABIN967945) anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 94-208) antibody (Image 3)
Product cited in: MacFarlane, Harper, Snowden et al.: "Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia." in: Oncogene, Vol. 21, Issue 44, pp. 6809-18, 2002 (PubMed).

Micheau, Thome, Schneider et al.: "The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45162-71, 2002 (PubMed).

Chang, Xing, Pan et al.: "c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis." in: The EMBO journal, Vol. 21, Issue 14, pp. 3704-14, 2002 (PubMed).

Wieder, Essmann, Prokop et al.: "Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3." in: Blood, Vol. 97, Issue 5, pp. 1378-87, 2001 (PubMed).

Chinnaiyan, ORourke, Tewari et al.: "FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis." in: Cell, Vol. 81, Issue 4, pp. 505-12, 1995 (PubMed).

Catalog No. ABIN967945
Contact our Customer Service for availability and price in your country.

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)