HCLS1 Associated Protein X-1 (HAX1) (AA 10-148) antibody

Details for Product No. ABIN968198
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Synonyms HAX1, hax1, HCLSBP1, HS1BP1, SCN3, HAX-1, Hs1bp1, HSP1BP-1, SIG-111, Silg111, mHAX-1s
AA 10-148
(22), (13), (13), (13), (11), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(123), (24), (23), (1), (1), (1)
(71), (35), (17)
Clonality (Clone)
Monoclonal ()
(7), (7), (7), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(106), (76), (32), (10), (8), (7), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
Shipping to United States ( )
Immunogen Human HAX-1 aa. 10-148
Clone 52-HAX
Isotype IgG1
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name HAX-1 (HAX1 Antibody Abstract)
Background Cell-cell interactions in the immune system, mediated by membrane-bound antigen receptors, trigger a cascade of signaling mechanisms collectively known as the T-cell response. Upon antigen binding, cellular tyrosine kinases are activated resulting in the phosphorylation of HS1 or Lck-binding protein 1 (LckBP1), which is involved in thymic negative selection. HS1 is one of the earliest intracellular proteins to be tyrosine phosphorylated in response to antigen-receptor cross-linking in T cells. HAX-1 (HS1-associated protein X-1) is a 35 kDa protein found associated with HS1 by co-immunoprecipitation assays and the two-hybrid system. HAX-1 is ubiquitously expressed and localized in the mitochondria, endoplasmic reticulum, and the nuclear envelope. The HS1-HAX-1 complex may be critical for signal transduction pathways initiated by antigen presentation to T cells.
Molecular Weight 35 kDa

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-HCLS1 Associated Protein X-1 (HAX1) (AA 10-148) antibody (ABIN968198) Western blot analysis of HAX-1 on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, l...
Immunofluorescence (IF) image for anti-HCLS1 Associated Protein X-1 (HAX1) (AA 10-148) antibody (ABIN968198) Immunofluorescent staining of HeLa cells with anti-HAX-1 antibody.
Product cited in: Suzuki, Demoliere, Kitamura et al.: "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 6, pp. 2736-44, 1997 (PubMed).

Catalog No. ABIN968198
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