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Details for Product No. ABIN968198

HCLS1 Associated Protein X-1 (HAX1) (AA 10-148) antibody

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Antigen
Synonyms HCLSBP1, HS1BP1, SCN3, HAX-1, Hs1bp1, HSP1BP-1, SIG-111, Silg111, mHAX-1s, HAX1, hax1
Epitope
»Alternatives AA 10-148
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 1 reference available
Catalog no. ABIN968198
Quantity 50 µg
Price
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Immunogen Human HAX-1
Clone AA6
Isotype IgG1
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name HAX-1
Background Cell-cell interactions in the immune system, mediated by membrane-bound antigen receptors, trigger a cascade of signaling mechanisms collectively known as the T-cell response. Upon antigen binding, cellular tyrosine kinases are activated resulting in the phosphorylation of HS1 or Lck-binding protein 1 (LckBP1), which is involved in thymic negative selection. HS1 is one of the earliest intracellular proteins to be tyrosine phosphorylated in response to antigen-receptor cross-linking in T cells. HAX-1 (HS1-associated protein X-1) is a 35 kDa protein found associated with HS1 by co-immunoprecipitation assays and the two-hybrid system. HAX-1 is ubiquitously expressed and localized in the mitochondria, endoplasmic reticulum, and the nuclear envelope. The HS1-HAX-1 complex may be critical for signal transduction pathways initiated by antigen presentation to T cells.
Molecular Weight 35 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Suzuki, Demoliere, Kitamura et al.: "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 6, pp. 2736-44, 1997 (PubMed).

Alternatives for antigen "HCLS1 Associated Protein X-1 (HAX1)", type "Antibodies"
Hosts (37), (29), (6)
Reactivities (73), (19), (17), (12), (12), (11)
Applications (59), (49), (9), (9), (4)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (8), (5), (4), (2), (2), (2), (1), (1)
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