anti-STAT4 antibody (Signal Transducer and Activator of Transcription 4) (AA 136-258)

Details for Product anti-STAT4 Antibody No. ABIN968254
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Synonyms SLEB11
AA 136-258
(70), (23), (15), (15), (12), (12), (7), (6), (6), (6), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Mouse (Murine), Rat (Rattus)
(305), (118), (87), (7), (7), (3), (2), (2), (2), (1), (1)
(201), (87), (28), (3), (2), (1)
Clonality (Clone)
Monoclonal ()
This STAT4 antibody is un-conjugated
(10), (10), (10), (9), (8), (6), (5), (4), (3), (3), (3), (3), (3), (3)
Immunofluorescence (IF), Western Blotting (WB)
(231), (105), (83), (49), (48), (41), (35), (30), (12), (11), (9), (6), (5), (4), (3), (1)
Pubmed 3 references available
Quantity 50 μg
Shipping to United States ( )
Immunogen Human Stat4 aa. 136-258
Clone 8-Stat4
Isotype IgG1
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Stat4 (STAT4 Antibody Abstract)
Background The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. With the discovery of additional members of the Stat family (Stat 3 & 4), the nomenclature has been revised to reflect the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. Stat4 has been reported to be 52% identical to Stat1 and 47% identical to Stat3. Functionally, Stat4 is similar to the other Stat proteins in that it requires tyrosine phosphorylation in order to stimulate its IFN-gamma activated site (GAS) binding activity. Expression of Stat4 appears to be limited to thymus, spleen, and testis. Its expression in several myeloid cell lines is differentially regulated during cellular differentiation. Co-transfection studies using JAK1 or JAK2 expression constructs indicate that Stat4 is a substrate for these kinases.
Synonyms: Signal Transducers and Activators of Transcription-4
Molecular Weight 89 kDa
Research Area Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-STAT4 antibody (Signal Transducer and Activator of Transcription 4) (AA 136-258) (ABIN968254) Western blot analysis of Stat4 on a rat testis lysate. Lane 1: 1:250, lane 2: 1:500, ...
Image no. 2 for anti-STAT4 antibody (Signal Transducer and Activator of Transcription 4) (AA 136-258) (ABIN968254) anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 136-258) antibody (Image 2)
Product cited in: Zhong, Wen, Darnell: "Stat3 and Stat4: members of the family of signal transducers and activators of transcription." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 4806-10, 1994 (PubMed).

Frank, Robertson, Bonni et al.: "Interleukin 2 signaling involves the phosphorylation of Stat proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7779-83, 1995 (PubMed).

Background publications Yamamoto, Quelle, Thierfelder et al.: "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation." in: Molecular and cellular biology, Vol. 14, Issue 7, pp. 4342-9, 1994 (PubMed).

Catalog No. ABIN968254
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