STAT4 antibody (N-Term)

Catalog No. ABIN2777897

Product Details anti-STAT4 Antibody

Target: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: IGGPLHNGLD QLQNCFTLLA ESLFQLRRQL EKLEEQSTKM TYEGDPIPMQ

Predicted Reactivity: Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against STAT4. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STAT4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 748 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-STAT4 antibody (ABIN2777897)

Torpey, Maher, Bothwell, Pober: "Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells." in: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26789-96, (2004) (PubMed).

Target Details for STAT4

Target: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Alternative Name: STAT4 (STAT4 Products)

Synonyms: SLEB11 antibody, signal transducer and activator of transcription 4 antibody, STAT4 antibody, stat4 antibody, Stat4 antibody

Background: STAT4 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
Alias Symbols: SLEB11
Protein Interaction Partner: UBC, ADRB2, TRIM28, FHL1, ZNF467, PIAS2, NMI, IL12RB2, IL12RB1, MAP2K6, STAT4, MAPK14, CREBBP, JUN, STAT3, IFNGR1,
Protein Size: 748

Molecular Weight: 86 kDa

Gene ID: 6775

NCBI Accession: NM_003151, NP_003142

UniProt: Q14765

Pathways: JAK-STAT Signaling