STAT4 antibody (N-Term)

Catalog No. ABIN2777897

This Rabbit Polyclonal antibody specifically detects STAT4 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Pig, Rabbit and Horse.It has been mentioned in 1 publication

Quick Overview for STAT4 antibody (N-Term) (ABIN2777897)

Target: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-STAT4 Antibody

Binding Specificity: N-Term

Purpose: STAT4 Antibody - N-terminal region

Sequence: IGGPLHNGLD QLQNCFTLLA ESLFQLRRQL EKLEEQSTKM TYEGDPIPMQ

Predicted Reactivity: Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against STAT4. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STAT4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111738

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-STAT4 antibody (ABIN2777897)

Torpey, Maher, Bothwell, Pober: "Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells." in: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26789-96, (2004) (PubMed).

Target Details for STAT4

Target: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Alternative Name: STAT4

Background:

Background Information: STAT4 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

Gene Name: Signal transducer and activator of transcription 4

Alternative Symbols: SLEB11

Protein Name: Signal transducer and activator of transcription 4

Molecular Weight: 86 kDa

Gene ID: 6775

NCBI Accession: NP_003142

UniProt: Q14765

Pathways: JAK-STAT Signaling