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Details for Product No. ABIN968867

Mitogen-Activated Protein Kinase 8 (MAPK8) (pThr183), (pTyr185) antibody

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Antigen
Synonyms
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c, Prkm8, AI849689, BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, ... show more
Epitope
»Alternatives pThr183, pTyr185
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN968867
Quantity 150 µg
Price
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Immunogen Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
Clone BC17
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name JNK
Background The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation. External stimuli, like endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment. Small GTPases of the Rho family, including cdc42, Rac1, and Rho, transmit the stress signals that initiate the signal cascade. JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49. JNK/SAPK, along with p38 and RK5/BMK1, comprise three classes of stress-activated MAPK groups. Complete activation of JNK/SAPK requires the phosphorylation of both Thr183 and Tyr185, which are located in a Thr-X-Tyr motif. The activation of these residues is believed to be carried out by MKK4 and MKK7. Active JNK/SAPK phosphorylates other kinases and multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.
Molecular Weight 43 & 56 kDa
Comment

Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968074

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Hinton, Henderson, Blanks et al.: "Monoclonal antibodies react with neuronal subpopulations in the human nervous system." in: The Journal of comparative neurology, Vol. 267, Issue 3, pp. 398-408, 1988 (PubMed).

Fleming, Armstrong, Morrice et al.: "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7." in: The Biochemical journal, Vol. 352 Pt 1, Issue 3, pp. 145-54, 2001 (PubMed).

Muyembe, Maes, Makulu et al.: "The hem of the garment." in: Seminars in dialysis, Vol. 14, Issue 1, pp. 76, 2001 (PubMed).

Kyriakis, Avruch: "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation." in: Physiological reviews, Vol. 81, Issue 2, pp. 807-69, 2001 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase 8 (MAPK8)", type "Antibodies"
Hosts (99), (64), (2)
Reactivities (151), (43), (34), (4), (2), (2), (2), (2), (1)
Applications (151), (75), (43), (43), (26), (20), (10), (8), (7), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Conjugates (1), (1)
Epitopes (21), (12), (11), (10), (8), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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