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Details for Product No. ABIN969131

Fibulin 5 (FBLN5) (AA 242-448) antibody

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Antigen
Synonyms ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50, A55, zgc:103575, FBLN5, MGC108414, Fibulin-5, DKFZp469K0327
Epitope
»Alternatives AA 242-448
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN969131
Quantity 100 µL
Price
407.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of FBLN5 (AA 242-448) expressed in E. coli.
Clone 1G6A4
Isotype IgG1
Purification Ascites
Alternative Name FBLN5
Background Synonyms:
EVEC, UP50, ARMD3, DANCE
FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.
Gene ID 10516
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Markova, Zou, Ringpfeil et al.: "Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene." in: American journal of human genetics, Vol. 72, Issue 4, pp. 998-1004, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Stone, Braun, Russell et al.: "Missense variations in the fibulin 5 gene and age-related macular degeneration." in: The New England journal of medicine, Vol. 351, Issue 4, pp. 346-53, 2004 (PubMed).

Wang, LeMaire, Chen et al.: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, 2005 (PubMed).

Alternatives for antigen "Fibulin 5 (FBLN5)", type "Antibodies"
Hosts (37), (27), (6)
Reactivities (67), (27), (23), (13), (4), (1), (1), (1)
Applications (62), (52), (20), (13), (10), (4), (4), (2), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (4), (2), (2), (1), (1)
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