Fibulin 5 (FBLN5) (AA 242-448) antibody

Antigen: Fibulin 5 (FBLN5)

Synonyms: EVEC, UP50, ARMD3, DANCE, FIBL-5, FLJ90059, A55, zgc:103575, FBLN5, MGC128763, MGC108414, Fibulin-5, DKFZp469K0327

Binding Site: AA 242-448

Clonality: Monoclonal (1G6A4)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN969131

Additional Information

Alternative name: FBLN5

Gene ID: 10516

Immunogen: Purified recombinant fragment of FBLN5 (AA 242-448) expressed in E. Coli.

Format: Liquid

Isotype: IgG1

Clone: 1G6A4

Description: FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.
Synonyms: EVEC, UP50, ARMD3, DANCE

Application Details

Application Notes: Western Blotting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Purification: Ascites

Buffer: Ascitic fluid containing 0.03% sodium azide.

Preservative: 0.03% sodium azide

Storage: Store at 4℃, for long term storage, store at -20℃.

Restrictions: For Research Use only

Publications

Product: Markova, Zou, Ringpfeil et al.: "Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene." in: American journal of human genetics, Vol. 72, Issue 4, pp. 998-1004, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Stone, Braun, Russell et al.: "Missense variations in the fibulin 5 gene and age-related macular degeneration." in: The New England journal of medicine, Vol. 351, Issue 4, pp. 346-53, 2004 (PubMed).

Wang, LeMaire, Chen et al.: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, 2005 (PubMed).