Fibulin 5 (FBLN5) (AA 242-448) antibody

Details for Product No. ABIN969131
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Antigen
Synonyms ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50, A55, zgc:103575, FBLN5, MGC108414, Fibulin-5, DKFZp469K0327
Epitope
AA 242-448
(7), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(70), (28), (24), (13), (4), (1), (1), (1)
Host
Mouse
(40), (30), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(67), (53), (23), (15), (10), (9), (7), (1)
Pubmed 4 references available
Catalog no. ABIN969131
Quantity 100 µL
Price
407.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of FBLN5 (AA 242-448) expressed in E. coli.
Clone 1G6A4
Isotype IgG1
Purification Ascites
Alternative Name FBLN5
Background Synonyms:
EVEC, UP50, ARMD3, DANCE
FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.
Gene ID 10516
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Fibulin 5 (FBLN5) (AA 242-448) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded human colon cancer (left) and breast cancer (right) showing cytoplasmic localization with DAB staining using FBLN5 mouse mAb.
anti-Fibulin 5 (FBLN5) (AA 242-448) antibody (2) Figure 1: Western blot analysis using FBLN5 mouse mAb against truncated FBLN5-His recombinant protein.
Product cited in: Markova, Zou, Ringpfeil et al.: "Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene." in: American journal of human genetics, Vol. 72, Issue 4, pp. 998-1004, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment...." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Stone, Braun, Russell et al.: "Missense variations in the fibulin 5 gene and age-related macular degeneration." in: The New England journal of medicine, Vol. 351, Issue 4, pp. 346-53, 2004 (PubMed).

Wang, LeMaire, Chen et al.: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, 2005 (PubMed).

Hosts (40), (30), (5)
Reactivities (70), (28), (24), (13), (4), (1), (1), (1)
Applications (67), (53), (23), (15), (10), (9), (7), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (3), (3), (2), (2), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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