anti-Fibulin 5 antibody (FBLN5)

Details for Product anti-FBLN5 Antibody No. ABIN969144
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Antigen
Synonyms zgc:103575, FBLN5, MGC108414, Fibulin-5, DKFZp469K0327, ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50, A55
Reactivity
Human
(108), (40), (34), (5), (2), (2), (2), (1), (1), (1)
Host
Mouse
(77), (29), (16)
Clonality (Clone)
Monoclonal ()
Conjugate
This Fibulin 5 antibody is un-conjugated
(11), (8), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(105), (89), (26), (18), (11), (10), (10), (3), (3), (1), (1)
Pubmed 4 references available
Quantity 100 μL
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Immunogen Purified recombinant fragment of Fibulin 5 expressed in E. coli.
Clone 3F10A5
Isotype IgG1
Purification Ascites
Alternative Name Fibulin 5 (FBLN5 Antibody Abstract)
Background Fibulin 5(FBLN5), with 448-amino acid protein (about 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Gene ID 10516
HGNC 10516
Research Area Cardiovascular, Atherosclerosis, Extracellular Matrix
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Fibulin 5 (FBLN5) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded human stomach carcinoma (...
anti-Fibulin 5 (FBLN5) antibody (2) Figure 1: Western blot analysis using Fibulin5 mouse mAb against truncated fibulin5 r...
Product cited in: Wang, LeMaire, Chen et al.: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, 2005 (PubMed).

Kadoya, Sasaki, Kostka et al.: "Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis." in: The British journal of dermatology, Vol. 153, Issue 3, pp. 607-12, 2005 (PubMed).

Wen, Hochholdinger, Sauer et al.: "The roothairless1 gene of maize encodes a homolog of sec3, which is involved in polar exocytosis." in: Plant physiology, Vol. 138, Issue 3, pp. 1637-43, 2005 (PubMed).

Lee, Roy, Mogford et al.: "Fibulin-5 promotes wound healing in vivo." in: Journal of the American College of Surgeons, Vol. 199, Issue 3, pp. 403-10, 2004 (PubMed).

Validation Images
Catalog No. ABIN969144
442.20 $
Plus shipping costs $45.00
Quantity
Price
100 μL
442.20 $

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