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PTK7 antibody (PTK7 Protein tyrosine Kinase 7)

Details for Product anti-PTK7 Antibody No. ABIN969374, Supplier: Login to see New
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Synonyms PTK7, CCK-4, CCK4, Srf, 8430404F20Rik, chz, mPTK7/CCK4, KLG
(111), (24), (21), (4), (2), (1), (1), (1), (1)
(81), (29), (2), (1)
Clonality (Clone)
Monoclonal ()
This PTK7 antibody is un-conjugated
(5), (5), (5), (3), (3), (3)
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(91), (66), (47), (18), (16), (11), (5), (2), (1), (1), (1)
Pubmed 3 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human PTK7 expressed in E. coli.
Clone 4F9
Isotype IgG1
Purification Ascites
Alternative Name PTK7 (PTK7 Antibody Abstract)
Background Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Molecular Weight 118 kDa
Gene ID 5754
HGNC 5754
Pathways RTK Signaling
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunohistochemistry (IHC) image for anti-PTK7 antibody (PTK7 Protein tyrosine Kinase 7) (ABIN969374) Figure 1: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using...
Western Blotting (WB) image for anti-PTK7 antibody (PTK7 Protein tyrosine Kinase 7) (ABIN969374) Figure 2: Western blot analysis using PTK7 mouse mAb against Hela (1), A431 (2), HCT1...
Product cited in: Shin, Maeng, Jung et al.: "Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis." in: Biochemical and biophysical research communications, Vol. 371, Issue 4, pp. 793-8, 2008 (PubMed).

Background publications Banga, Ozer, Park et al.: "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1-->p12.2 by fluorescence in situ hybridization." in: Cytogenetics and cell genetics, Vol. 76, Issue 1-2, pp. 43-4, 1997 (PubMed).

Mossie, Jallal, Alves et al.: "Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family." in: Oncogene, Vol. 11, Issue 10, pp. 2179-84, 1995 (PubMed).

Catalog No. ABIN969374
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