PTK7 Protein tyrosine Kinase 7 (PTK7) antibody

Details for Product No. ABIN969374
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Antigen
Synonyms PTK7, CCK-4, CCK4, Srf, 8430404F20Rik, chz, mPTK7/CCK4, KLG
Reactivity
Human
(94), (27), (20), (7), (1), (1)
Host
Mouse
(70), (26), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (4), (4), (4), (4)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(89), (62), (47), (21), (13), (8), (7), (5), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
Options
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Catalog No. ABIN969374
363.00 $
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Immunogen Purified recombinant fragment of human PTK7 expressed in E. coli.
Clone 4F9
Isotype IgG1
Purification Ascites
Alternative Name PTK7
Background Synonyms:
CCK4, PTK7
Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but rηin roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skelηl muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Molecular Weight 118 kDa
Gene ID 5754
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-PTK7 Protein tyrosine Kinase 7 (PTK7) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using PTK7 mouse mAb with DAB staining.
anti-PTK7 Protein tyrosine Kinase 7 (PTK7) antibody (2) Figure 1: Western blot analysis using PTK7 mouse mAb against Hela (1), A431 (2), HCT116 (3), Caco2 (4), HepG2 (5) and MCF-7 (6) cell lysate.
Product cited in: Shin, Maeng, Jung et al.: "Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis." in: Biochemical and biophysical research communications, Vol. 371, Issue 4, pp. 793-8, 2008 (PubMed).

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