PTK7 Protein tyrosine Kinase 7 (PTK7) antibody

Antigen: PTK7 Protein tyrosine Kinase 7 (PTK7)

Synonyms: CCK4, mPTK7/CCK4, 8430404F20Rik, Srf, KLG, PTK7

Clonality: Monoclonal (4F9)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN969374

Additional Information

Alternative name: PTK7

Gene ID: 5754

Immunogen: Purified recombinant fragment of human PTK7 expressed in E. Coli.

Format: Liquid

Isotype: IgG1

Clone: 4F9

Description: Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Synonyms: CCK4, PTK7

Molecular Weight: 118kDa

Application Details

Application Notes: Western Blotting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Purification: Ascites

Buffer: Ascitic fluid containing 0.03% sodium azide.

Preservative: 0.03% sodium azide

Storage: Store at 4℃, for long term storage, store at -20℃.

Restrictions: For Research Use only

Publications

Product: Shin, Maeng, Jung et al.: "Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis." in: Biochemical and biophysical research communications, Vol. 371, Issue 4, pp. 793-8, 2008 (PubMed).