WD Repeat Domain 5 (WDR5) antibody

Details for Product No. ABIN969456
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Antigen
Synonyms zgc:56591, zgc:76895, wu:fk47f04, wdr5-a, MGC80538, wdr5-b, MGC81485, big-3, swd3, xwdr5, BIG-3, SWD3, 2410008O07Rik, AA408785, AA960360, Big, Big-3
Reactivity
Human
(51), (8), (4)
Host
Mouse
(36), (19), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(51), (32), (9), (7), (5), (4), (3), (2), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN969456
363.00 $
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Immunogen Purified recombinant fragment of human WDR5 expressed in E. coli.
Clone 7B11
Isotype IgG2b
Purification Ascites
Alternative Name WDR5
Background Synonyms:
SWD3, BIG-3, WDR5
WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
Molecular Weight 36.6 kDa
Gene ID 11091
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-WD Repeat Domain 5 (WDR5) antibody Figure 1: Western blot analysis using WDR5 mouse mAb against Hela (1) cell lysate.
Product cited in: Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

Patel, Vought, Dharmarajan et al.: "A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex." in: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32162-75, 2008 (PubMed).

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