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Details for Product No. ABIN969456

WD Repeat Domain 5 (WDR5) antibody

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Antigen
Synonyms SWD3, BIG-3, Big, Big-3, AA408785, AA960360, 2410008O07Rik, zgc:56591, zgc:76895, wu:fk47f04, wdr5-a, MGC80538, wdr5-b, MGC81485, big-3, swd3, xwdr5
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN969456
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human WDR5 expressed in E. coli.
Clone 7B11
Isotype IgG2b
Purification Ascites
Alternative Name WDR5
Background Synonyms:
SWD3, BIG-3, WDR5
WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
Molecular Weight 36.6 kDa
Gene ID 11091
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

Patel, Vought, Dharmarajan et al.: "A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex." in: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32162-75, 2008 (PubMed).

Alternatives for antigen "WD Repeat Domain 5 (WDR5)", type "Antibodies"
Hosts (29), (11), (1)
Reactivities (36), (6), (3)
Applications (36), (21), (5), (3), (2), (2), (1)
Conjugates (1), (1)
Epitopes (11), (4), (4), (2), (2), (1), (1)
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