Browse our AIFM1 Proteins (AIFM1)

Full name:
Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 Proteins (AIFM1)
On are 15 Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) Proteins from 6 different suppliers available. Additionally we are shipping AIFM1 Antibodies (181) and AIFM1 Kits (12) and many more products for this protein. A total of 227 AIFM1 products are currently listed.
Aif, AIFM1, AIFsh2, CG7263, CMTX4, COWCK, COXPD6, DDBDRAFT_0187853, DDBDRAFT_0191137, DDB_0187853, DDB_0191137, DmAIF, Dmel\\CG7263, GB16024, Hq, mAIF, PCD8, Pdcd8, zgc:91994
list all proteins Gene Name GeneID UniProt
AIFM1 26926 Q9Z0X1
AIFM1 83533 Q9JM53
AIFM1 9131 O95831

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AIFM1 Proteins (AIFM1) by Origin

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More Proteins for AIFM1 Interaction Partners

Pig (Porcine) Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) interaction partners

  1. Mitochondrial apoptosis-inducing factor was found to translocate to the nucleus during porcine epidemic diarrhea virus infection.

Fruit Fly (Drosophila melanogaster) Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) interaction partners

  1. Drosophila Apoptosis-inducing factor (AIF) is a mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function.

Cow (Bovine) Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) interaction partners

  1. apoptosis-inducing factor(AIF) was expressed in luminal alveolar cells and in concert with a change in bax (show BAX Proteins) protein to bcl-2 (show BCL2 Proteins) protein ratio might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses(AIF)

  2. Mycobacterium bovis-induced macrophage cell death is caspase (show CASP3 Proteins) independent with apoptosis-inducing factor participation.

Mouse (Murine) Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) interaction partners

  1. X-ray irradiation induces apoptosis of mouse GC1 sperm cells via nuclear translocation of AIF.

  2. The first structure of a pathogenic AIF variant in complex with NAD+ is reported. The G307E mutation leads to wrong positioning of NAD+ adenylate moiety.

  3. AIF deficiency is a risk factor for the development of diabetic kidney disease.

  4. In conclusion, calpain was involved in oxygen glucose deprivation-induced RGC-5 necroptosis with the increased expression of its downstream molecule tAIF.

  5. The results identify new protein-protein interactions between AIF-Cx43 (show GJA1 Proteins), ETFB (show ETFB Proteins)-Cx43 (show GJA1 Proteins) and AIF-ETFB (show ETFB Proteins) as possible players in the regulation of the mitochondrial redox state.

  6. our findings suggest that MIA40 (show CHCHD4 Proteins) reduction contributes to the effects of AIF deficiency on OXPHOS, as it may impact on the correct assembly and maintenance of the respiratory subunits.

  7. These results indicate that the adenylate moiety of NAD(+)/H is crucial for the association with AIF and for the subsequent structural reorganization of the complex, but not for protein dimerization.

  8. Taken together, these data suggest that AIF is likely to play a region-specific role in AD-related caspase-independent PCD, which is consistent with aging-associated mitochondrial impairment and oxidative stress.

  9. findings postulate that AIF depletion mediates a preconditioning effect protecting neuronal cells from subsequent glutamate (show GRIN1 Proteins) toxicity through reduced levels of complex I protein

  10. AIF downregulation provides not only long-term overall neuroprotection after hypoxia-ischemia, but also protects neural progenitor cells, thereby rescuing hippocampal neurogenesis.

Human Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) interaction partners

  1. Downregulation of AIF by hypoxia causes oxidative inactivation of the lipid phosphatase activity of phosphatase and tensin homolog on chromosome 10 (PTEN), with ensuing activation of Akt (show AKT1 Proteins) kinase, phosphorylation of the Akt (show AKT1 Proteins) substrate GSK-3beta and activation of WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in colon cancer cells.

  2. novel pathway for mda-7/IL-24 (show IL24 Proteins)-induced caspase (show CASP3 Proteins)-independent apoptosis in neuroblastoma (show ARHGEF16 Proteins) cells mediated through modulation of AIF, ATM (show ATM Proteins), and gamma-H2AX (show H2AFX Proteins).

  3. Study defines the mechanism whereby AIF is allosterically modulated by charge-complex formation with NADH. Two distinct molecular pathways couple AIF's active site to dimerization and release of its regulatory C-loop insert with implications for AIF allosteric switching in cell survival and death.

  4. Whole exome sequencing indicated a single plausible candidate - the p.Asp237Gly variant in apoptosis inducing factor mitochondria associated 1 (AIFM1; chr. Xq26.1), and the p.Asp237Gly segregated with disease in two families.

  5. Only a drastic decrease in the expression level or/and redox activity of AIF tends to cause an early and severe neurodegeneration, whereas less pronounced changes in the AIF properties could lead to a broad range of slowly progressive neurological disorders.

  6. AIF translocation plays a role in influenza-virus-induced apoptosis.

  7. Copper induces the activation of apoptosis through casp3 (show CASP3 Proteins)/casp8 (show CASP8 Proteins)/casp9 (show CASP9 Proteins)/AIF/TP53 (show TP53 Proteins) signaling pathways. Suggest that apoptosis activation mechanism is dependent on the concentration, time of exposure to Cu and cell type.

  8. Estradiol inhibits oxidative stress-induced (show SQSTM1 Proteins) accumulation of AIF in nucleolus and PARP1 (show PARP1 Proteins)-dependent cell death via estrogen receptor alpha (show ESR1 Proteins) in MCF-7 cells.

  9. AIF may participate in but not be dominant in the process of retinal pigment epithelium cell apoptosis induced by oxidative stress.

  10. Altogether these data indicate that AIF supports the growth and survival of metabolically defined pancreatic cancer cells and that this metabolic function may derive from a novel mechanism so far undocumented in other cancer types.

AIFM1 Protein Profile

Protein Summary

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Alternative names and synonyms associated with AIFM1

  • apoptosis-inducing factor, mitochondrion-associated, 1 (aifm1)
  • apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1)
  • Apoptosis inducing factor (AIF)
  • apoptosis inducing factor (AIF)
  • apoptosis inducing factor (aif)
  • allograft inflammatory factor 1 (AIF1)
  • apoptosis-inducing factor, mitochondrion-associated 1 (Aifm1)
  • apoptosis-inducing factor, mitochondrion-associated 1 (aifm1)
  • Aif protein
  • AIFM1 protein
  • AIFsh2 protein
  • CG7263 protein
  • CMTX4 protein
  • COWCK protein
  • COXPD6 protein
  • DDBDRAFT_0187853 protein
  • DDBDRAFT_0191137 protein
  • DDB_0187853 protein
  • DDB_0191137 protein
  • DmAIF protein
  • Dmel\\CG7263 protein
  • GB16024 protein
  • Hq protein
  • mAIF protein
  • PCD8 protein
  • Pdcd8 protein
  • zgc:91994 protein

Protein level used designations for AIFM1

programmed cell death 8 (apoptosis-inducing factor) , programmed cell death 8 , apoptosis-inducing factor, mitochondrion-associated, 1 , mammary apoptosis inducing factor , flavoprotein and apoptosis inductor , apoptosis-inducing factor 1, mitochondrial-like , AIF-PA , AIF-PB , AIF-PC , CG7263-PA , CG7263-PB , CG7263-PC , apoptosis inducing factor , AIF-1 , anti-inflammatory factor 1 , apoptosis-inducing factor 1, mitochondrial , harlequin , programmed cell death protein 8 , striatal apoptosis-inducing factor

549998 Xenopus (Silurana) tropicalis
768258 Felis catus
100054546 Equus caballus
100188912 Ovis aries
100387002 Callithrix jacchus
100471854 Ailuropoda melanoleuca
100524062 Sus scrofa
100562576 Anolis carolinensis
100605967 Nomascus leucogenys
100615914 Pan troglodytes
33390 Drosophila melanogaster
412212 Apis mellifera
8626532 Dictyostelium discoideum AX4
280989 Bos taurus
26926 Mus musculus
83533 Rattus norvegicus
373125 Danio rerio
9131 Homo sapiens
428688 Gallus gallus
481048 Canis lupus familiaris
535714 Bos taurus
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