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Overexpression of FOXM1 (show FOXM1 Proteins), XIAP (show XIAP Proteins), and Survivin contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients.
Survivin, Bcl-2 (show BCL2 Proteins), and KAI1 (show CD82 Proteins) are metastasis-related factors in cervical cancer. Overexpression of survivin and Bcl-2 (show BCL2 Proteins), and low expression of KAI1 (show CD82 Proteins) promotes cervical cancer progress and metastasis.
Survivin, p53 (show TP53 Proteins), and beta-catenin (show CTNNB1 Proteins) overexpression, as prognostic markers, might suggest that the Urothelial carcinomas are biologically aggressive with the poor prognosis
selective activity of 2DG treatment on Survivin-overexpressing tumor cells was also confirmed in a xenograft mouse model, which further supports our hypothesis that glycolysis inhibitors might be useful drugs in the treatment of NB
findings suggest that USP22 (show USP22 Proteins) may be involved in hepatocellular carcinoma progression in cooperation with survivin.
Data show that down regulation of survivin gene in HO8910PM cells with small interference RNA (siRNA) resulted in increased sensitivity to S-allylmercaptocysteine (SAMC) together with a decrease in invasiveness of tumor cells.
BIRC5 -31C>G polymorphism could be useful pharmacogenetic marker for methotrexate treatment response in rheumatoid arthritis
Suppression of survivin with specific inhibitor YM155 significantly increased the susceptibility of KG1a cells to BUS (show CDH23 Proteins).
the Notch1 (show NOTCH1 Proteins)/survivin crosstalk contributes to the maintenance of stemness in human keratinocytes.
IWR-1 has the potential to suppress tumor metastasis by inhibiting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway as well as survivin expression
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL (show PRL Proteins)-mediated beta cell proliferation via Akt (show AKT1 Proteins), STAT5 (show STAT5A Proteins)-PIM (show PIM1 Proteins) and ERK (show EPHB2 Proteins) signalling pathways during pregnancy
Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.
Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury
NR4A1 (show NR4A1 Proteins) protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP (show DDIT3 Proteins) expression.
Studies indicate the importance of survivin in Sonic hedgehog (SHH (show SHH Proteins))-driven medulloblastoma (MB).
the Skp1 (show SKP1 Proteins).Cul1 (show CUL1 Proteins).F-box protein (show FBXO30 Proteins) complex subunit Fbxl7 (show FBXL7 Proteins) modulates mitochondrial function by controlling the cellular abundance of survivin
Both HIF1-alpha (show HIF1A Proteins) and survivin are involved in the retinal neovascularization in oxygen-induced retinopathy.
survivin-mediated radio-adaptive response is dependent upon the ability of cells to activate NFkappaB
These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha