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Significantly higher expression of survivin protein in gallbladder cancer as compared to cholelithiasis group suggests its role in gallbladder carcinogenesis though it may not have prognostic value.
Survivin protein expression levels were downregulated in both cell lines.
Survivin and miRNA-16-1 as potential biomarkers.
The aim of the study was to evaluate the caspase-3 and survivin expression in correlation with MIB-1 expression in gliomas of various grade.
High survivin expression is associated with ovarian cancer.
High survivin expression is Associated with Acne Vulgaris.
p53 (show TP53 Proteins) and Bax (show BAX Proteins) might play an important role in microcystin-LR (MC-LR)-induced apoptosis in HepG2 cells in which PUMA (show BBC3 Proteins) and survivin were involved.
This study aimed to demonstrate the usefulness of mRNA expression levels of BIRC5 in brush cytology specimens combined with cytology for the diagnosis of malignant biliary stricture
IGF-1 (show IGF1 Proteins) signaling activated survivin expression and controlled the expression of EMT (show ITK Proteins) biomarkers in the development of GC.
Increased survivin expression in choledochal cyst tissue correlated with certain clinical parameters of congenital choledochal cysts.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
Survivin is a key regulator of gut (show GUSB Proteins) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 Proteins) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cancer stem cell formation and cancer SCC (show CYP11A1 Proteins) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 Proteins) and ki67 (show MKI67 Proteins).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL (show PRL Proteins)-mediated beta cell proliferation via Akt (show AKT1 Proteins), STAT5 (show STAT5A Proteins)-PIM (show PIM1 Proteins) and ERK (show EPHB2 Proteins) signalling pathways during pregnancy
Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.
Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury
NR4A1 (show NR4A1 Proteins) protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP (show DDIT3 Proteins) expression.
Studies indicate the importance of survivin in Sonic hedgehog (SHH (show SHH Proteins))-driven medulloblastoma (MB).
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha