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The results indicate that CXCL12 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) protects colorectal cancer cells against radiotherapy via survivin, implying an important underlying mechanism of resistance to radiotherapy during colorectal cancer therapy.
Survivin was regulated by TGF-beta (show TGFB1 Proteins) and was found to be highly expressed during mucosal healing following intestinal inflammation
Studies showed that survivin mRNA and protein levels are overexpressed in cervical cancer cells. [meta-analysis]
Using recombinant proteins, this study investigated the influence of survivin on the inhibition of caspase-9 (show CASP9 Proteins) by XIAP (show XIAP Proteins) in vitro. With a fluorescence-based assay for the apoptosome-stimulated activity of caspase-9 (show CASP9 Proteins), the study shows that survivin has no effect on the inhibition of caspase-9 (show CASP9 Proteins) by XIAP (show XIAP Proteins), neither in the presence nor in the absence of Smac (show DIABLO Proteins).
morphine promotes renal cell carcinoma (show MOK Proteins) growth and increases RCC (show XRCC1 Proteins) progression via over-expression of Survivin
Present study indicated that survivin expression is a significant prognostic factor and that survivin is a promising therapeutic target for endometrial cancer.
Study suggests that BIRC5 may play a role as a protective factor in the development of intracerebral hemorrhage, and also the brain damage inducing after intracerebral hemorrhage
Results showed that both PARP6 and survivin exhibited higher expression in colorectal adenocarcinoma tissues and cell lines. knockdown of either PARP6 or survivin promotes cell apoptosis and inhibits the cell invasion of colorectal adenocarcinoma cells suggesting a significant correlation between theses 2 proteins.
the results of the present study demonstrated that injection of the LV carrying survivin into punctured rabbit intervertebral discs acted to delay changes associated with the degeneration of the discs.
No significant differences of p-Akt (show AKT1 Proteins) and survivin expression were found between PTC (show F9 Proteins) patients with type 2 diabetes mellitus and papillary thyroid carcinoma patients without type 2 diabetes mellitus
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin is a key regulator of gut (show GUSB Proteins) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 Proteins) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cancer stem cell formation and cancer SCC (show CYP11A1 Proteins) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 Proteins) and ki67 (show MKI67 Proteins).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL (show PRL Proteins)-mediated beta cell proliferation via Akt (show AKT1 Proteins), STAT5 (show STAT5A Proteins)-PIM (show PIM1 Proteins) and ERK (show EPHB2 Proteins) signalling pathways during pregnancy
Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.
Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha