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we discovered a novel mechanism mediated by Smad4 (show SMAD4 Proteins) to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/CDC2 (show CDK1 Proteins)/survivin cascade.
It also inhibits the mRNA levels of Survivin gene.
Overexpression of miR494 and silencing survivin RNA through the use of survivin shRNA inhibited the expression of survivin and attenuated PC3 (show PCSK1 Proteins) cell growth in vitro and in vivo.
Expression of livin (show BIRC7 Proteins), survivin and caspase-3 (show CASP3 Proteins) are closely related to the occurrence and development of prostatic cancer.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cancer stem cell formation and cancer SCC (show CYP11A1 Proteins) development.
results indicate that survivin functions as a common mediator of gemcitabine- and TRAIL-induced cell death.
We defined Survivin as a constitutive actor of HR in breast cancers, and implies that its inhibition would enhance cell vulnerability upon PARP inhibition.
Studies on survivin in NP cells may aid in increasing the understanding of the complex processes underlying NP cell degeneration, and could provide fundamental information for gene therapy to inhibit this degeneration in vitro
Suggest that the p53-p21-DREAM-CDE/CHR pathway regulates p53-dependent repression of Survivin, CDC25C, and PLK1 in HCT116 cells.
Overexpression of FOXM1 (show FOXM1 Proteins), XIAP (show XIAP Proteins), and Survivin contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 Proteins) and ki67 (show MKI67 Proteins).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL (show PRL Proteins)-mediated beta cell proliferation via Akt (show AKT1 Proteins), STAT5 (show STAT5A Proteins)-PIM (show PIM1 Proteins) and ERK (show EPHB2 Proteins) signalling pathways during pregnancy
Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.
Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury
NR4A1 (show NR4A1 Proteins) protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP (show DDIT3 Proteins) expression.
Studies indicate the importance of survivin in Sonic hedgehog (SHH (show SHH Proteins))-driven medulloblastoma (MB).
the Skp1 (show SKP1 Proteins).Cul1 (show CUL1 Proteins).F-box protein (show FBXO30 Proteins) complex subunit Fbxl7 (show FBXL7 Proteins) modulates mitochondrial function by controlling the cellular abundance of survivin
Both HIF1-alpha (show HIF1A Proteins) and survivin are involved in the retinal neovascularization in oxygen-induced retinopathy.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha