Browse our BIRC5 Proteins (BIRC5)

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Baculoviral IAP Repeat-Containing 5 Proteins (BIRC5)
On are 24 Baculoviral IAP Repeat-Containing 5 (BIRC5) Proteins from 8 different suppliers available. Additionally we are shipping BIRC5 Antibodies (85) and BIRC5 Kits (13) and many more products for this protein. A total of 131 BIRC5 products are currently listed.
AAC-11, AP14, Api4, EPR-1, survivin40, TIAP
list all proteins Gene Name GeneID UniProt
BIRC5 332 O15392
BIRC5 11799 O70201
BIRC5 64041 Q9JHY7

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BIRC5 Proteins (BIRC5) by Origin

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More Proteins for BIRC5 Interaction Partners

Human Baculoviral IAP Repeat-Containing 5 (BIRC5) interaction partners

  1. Data suggest that the first 22 bp of exon 3 in BIRC5 contain cis (show CISH Proteins)-acting elements that enhance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 (show KHDRBS1 Proteins) is a possible trans-acting factor that binds to this cis (show CISH Proteins)-acting element and regulates exon 3 splicing. (BIRC5/survivin = baculoviral IAP repeat containing 5; Sam68 (show KHDRBS1 Proteins) = GAP-associated tyrosine phosphoprotein p62 (show KHDRBS1 Proteins))

  2. our data suggest the existence of a novel pre-metastatic phase quiescent-breast cancer stem cells (Q-BCSCs) before epithelial to mesenchymal transition and SURVIVIN acts as a marker for Quiescent-BCSCs

  3. Expressions of SDF-1 (show CXCL12 Proteins), survivin and smac (show DIABLO Proteins) were significantly higher in epithelial ovarian cancer tissue than those in normal tissue.

  4. Survivin expression predicted disease-free survival in high grade papillary urothelial carcinomas.

  5. G/G genotype of the survivin -31C/G polymorphism might be a risk factor for UC development.

  6. Studies indicate that survivin expression was associated with more aggressive clinical features and predicted poor cancer-specific survival (CSS (show CMAS Proteins)) and overall survival (OS) in patients with renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)).

  7. This study shows that both survivin and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (show IDH1 Proteins)-mutation status

  8. this study shows that c-IAP-2 (show BIRC3 Proteins) may prevent HIV-viral protein -mediated mitochondrial depolarization through stabilizing TRAF-1 (show TRAF1 Proteins)/2 expression and sequential inhibition of caspase-8 (show CASP8 Proteins), Bid (show BID Proteins), and Bax (show BAX Proteins)

  9. the N-terminus of survivin is a mitochondrial-targeting sequence that regulates Src (show SRC Proteins).

  10. Reciprocal regulation of BMF (show BMF Proteins) and BIRC5 is linked to Eomes (show EOMES Proteins) overexpression in colorectal cancer.

Cow (Bovine) Baculoviral IAP Repeat-Containing 5 (BIRC5) interaction partners

  1. Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.

Pig (Porcine) Baculoviral IAP Repeat-Containing 5 (BIRC5) interaction partners

  1. Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.

  2. Report survivin expression in the normal pancreas.

Mouse (Murine) Baculoviral IAP Repeat-Containing 5 (BIRC5) interaction partners

  1. this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin

  2. Survivin was regulated by TGF-beta (show TGFB1 Proteins) and was found to be highly expressed during mucosal healing following intestinal inflammation

  3. Survivin is a key regulator of gut (show GUSB Proteins) tissue integrity by regulating epithelial homeostasis in the stem cell niche.

  4. TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 Proteins) in CPCs to mediate cardioprotection and improve cardiac function.

  5. Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cancer stem cell formation and cancer SCC (show CYP11A1 Proteins) development.

  6. In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 Proteins) and ki67 (show MKI67 Proteins).

  7. survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.

  8. Survivin directly participates in PRL (show PRL Proteins)-mediated beta cell proliferation via Akt (show AKT1 Proteins), STAT5 (show STAT5A Proteins)-PIM (show PIM1 Proteins) and ERK (show EPHB2 Proteins) signalling pathways during pregnancy

  9. Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.

  10. Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury

BIRC5 Protein Profile

Protein Summary

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with BIRC5

  • baculoviral IAP repeat containing 5 (BIRC5)
  • baculoviral IAP repeat-containing 5-like (LOC696283)
  • baculoviral IAP repeat-containing 5 (Birc5)
  • AAC-11 protein
  • AP14 protein
  • Api4 protein
  • EPR-1 protein
  • survivin40 protein
  • TIAP protein

Protein level used designations for BIRC5

baculoviral IAP repeat-containing 5 (survivin) , baculoviral IAP repeat-containing protein 5 , baculoviral IAP repeat-containing 5 (survivin)-like , apoptosis inhibitor survivin , baculoviral IAP repeat-containing 5 , apoptosis inhibitor 4 , survivin variant 3 alpha , survivin

455276 Pan troglodytes
696283 Macaca mulatta
100172652 Pongo abelii
332 Homo sapiens
414925 Bos taurus
493835 Felis catus
397266 Sus scrofa
442936 Canis lupus familiaris
11799 Mus musculus
64041 Rattus norvegicus
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