Survivin Protein
Quick Overview for Survivin Protein (ABIN7318193)
Target
See all Survivin (BIRC5) ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human Survivin/BIRC5 Protein
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Sequence
- Met 1-Asp142
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Characteristics
- Recombinant Human Baculoviral IAP Repeat-Containing Protein 5 is produced by our E.coli expression system and the target gene encoding Met1-Asp142 is expressed.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) protein (His tag)
custom-made BIRC5 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) protein (Calmodulin (CaM))BIRC5 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) protein (GST tag)BIRC5 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-140), (full length) protein (His tag)BIRC5 Origin: Mouse Host: Yeast Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
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Alternative Name
- Survivin/BIRC5
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Background
- API4,Apoptosis Inhibitor 4,Apoptosis Inhibitor Survivin,BIRC5,Baculoviral IAP Repeat-Containing Protein 5,IAP4,Baculoviral IAP Repeat-Containing Protein 5 (BIRC5) belongs to the IAP family. BIRC5 exists as a homodimer in the apo state and as a monomer in the CPC-bound state. BIRC5 contains one BIR repeat and is expressed only in fetal kidney and liver, and to lesser extent, lung and brain. BIRC5 functions as a multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. BIRC5 is also a component of a chromosome passage protein complex (CPC), which is essential for chromosome alignment and segregation during mitosis and cytokinesis. BIRC5 acts as an important regulator of the localization of this complex.
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Molecular Weight
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Calculated MW: 16.4 kDa
Observed MW: 16-18 kDa
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Gene ID
- 332
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UniProt
- O15392
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Pathways
- Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding
Target
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