Survivin Protein (AA 1-140, full length) (His-SUMO Tag)

Catalog No. ABIN5709139

Product Details

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Protein Type: Recombinant

Protein Characteristics: full length, AA 1-140

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Survivin protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQMEELTVSE FLKLDRQRAK NKIAKETNNK QKEFEETAKT TRQSIEQLAA

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Alternative Name: BIRC5 (BIRC5 Products)

Synonyms: AP14 Protein, API4 Protein, EPR-1 Protein, AAC-11 Protein, Api4 Protein, TIAP Protein, survivin40 Protein, bir5a Protein, survivin Protein, BIR1 Protein, Su2 Protein, XBIR1 Protein, XSurvivin1 Protein, Xsvv1 Protein, api4 Protein, bir1-A Protein, epr-1 Protein, svv1 Protein, xSurvivin Protein, xsurv Protein, Su1 Protein, birc5.2 Protein, svv2 Protein, xSurvivin2 Protein, bir5b Protein, SIX Protein, birc5.2-a Protein, birc5.2-b Protein, baculoviral IAP repeat containing 5 Protein, baculoviral IAP repeat-containing 5 Protein, baculoviral IAP repeat containing 5a Protein, baculoviral IAP repeat-containing 5, gene 1 L homeolog Protein, baculoviral IAP repeat containing 5 L homeolog Protein, baculoviral IAP repeat containing 5b Protein, baculoviral IAP repeat containing 5 S homeolog Protein, BIRC5 Protein, Birc5 Protein, birc5a Protein, birc5.1.L Protein, birc5.2.L Protein, birc5b Protein, birc5.2.S Protein

Background: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex, directs CPC movent to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 .

Molecular Weight: 32.3 kDa

UniProt: O70201

Pathways: Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding