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Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
CAPNS1 depletion is coupled to impairment of breast cancer cell growth.
High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2 (show MMP2 Proteins).
HBXIP (show HBXIP Proteins) was able to up-regulate Capn4 at the levels of promoter.
The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma.
Capn4 can contribute to hepatocellular carcinoma growth and metastasis
Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma (show MOK Proteins) tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival.
Capn4 upregulated MMP2 (show MMP2 Proteins) via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65 (show GORASP1 Proteins), a subunit of NF-kappaB (show NFKB1 Proteins).
This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments.
Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma
A new single nucleotide polymorphism was found in the bovine CAPNS1 gene exon 11 coding for the 3'UTR.
Mitochondrial calpain-1 (show CAPN1 Proteins) disrupts ATP synthase, leading to mitochondrial reactive oxygen species generation, which promotes proinflammatory response and myocardial dysfunction during endotoxemia.
Calpain in osteoblasts regulates cell proliferation through its regulation of p27Kip1 (show CDKN1B Proteins). Osteoblast-specific capns1 knockout mice developed a high-fat diet-induced excess body weight gain and impaired glucose tolerance.
effects of Capn4 deletion may be mediated through prevention of IkappaB degradation and NF-kappaB (show NFKB1 Proteins) activation, resulting in inhibition of inflammatory responses.
Calpain 4 is essential for the tyrosine phosphorylation of galectin-3 (show LGALS3 Proteins), and its ultimate secretion from the cell, and its secretion probably interferes with the production of traction forces.
osteoblast-specific Capns1 knockout mice with osteoporosis and reduced bone resorptive function, exhibited reduced serum uncarboxylated osteocalcin (show BGLAP Proteins) levels and a lean phenotype under a normal chow diet.
Calpain 4 is not necessary for LFA-1 (show ITGAL Proteins)-mediated adhesion, conjugation or migration.
Data suggest that the calpain small subunit, Capn4, is essential for proper chondrocyte functions in embryonic growth plates.
calpain-mediated endoproteolytic cleavage of PrP(Sc) may be an important event in prion (show PRNP Proteins) propagation
In calpain-deficient cells, autophagy is impaired with a resulting dramatic increase in apoptotic cell death.
The molecular ordering of PARP-1 (show PARP1 Proteins), calpains, Bax (show BAX Proteins), and AIF (show AIFM1 Proteins) activation is established.
Polymorphisms in PPARGC1A and CAPNS1 genes may affect meat quality traits.
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.
calpain, small subunit 1
, CANP small subunit
, calcium-activated neutral proteinase small subunit
, calcium-dependent protease small subunit 1
, calcium-dependent protease, small subunit
, calpain 4, small subunit (30K)
, calpain regulatory subunit
, calpain small subunit 1
, calpain, small polypeptide
, calpain 4
, calpain I light subunit