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anti-Mouse (Murine) Caspase 12 Antibodies:
anti-Rat (Rattus) Caspase 12 Antibodies:
anti-Human Caspase 12 Antibodies:
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Human Polyclonal Caspase 12 Primary Antibody for IHC (p), WB - ABIN3042658
Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect. in PLoS ONE 2011
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mice ablated for caspase-12 develop spontaneous obesity and insulin resistance.
Bnip3L (show BNIP3L Antibodies) and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
Caspase-12 plays a pivotal role in CCl4 (show CCL4 Antibodies)-induced hepatic apoptosis through the activation of the downstream effector caspase-3 (show CASP3 Antibodies) directly and/or indirectly via caspase-9 (show CASP9 Antibodies) activation.
We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration.
Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin (show DMD Antibodies)-deficient mdx (show DMD Antibodies) mouse, the model for Duchenne muscular dystrophy (show DMD Antibodies).
Tauroursodeoxycholic acid intervention down-regulated GRP78 (show HSPA5 Antibodies) and CHOP (show DDIT3 Antibodies) expression and Caspase 12 activation.
Findings indicate that although caspase-12 deficiency results in enhanced pro-inflammatory and immunoregulatory cytokine levels in sera during P. yoelii 17XL infection, these responses are not essential for protection against lethal malaria infection.
caspase-12 competed with NEMO (show IKBKG Antibodies) for association with IkappaB kinase-alpha (show CHUK Antibodies)/beta, effectively preventing the formation of the IkappaB kinase (show CHUK Antibodies) complex and inhibiting downstream transcriptional activation by NF-kappaB (show NFKB1 Antibodies).
Caspase-12 was required for an effective antiviral immune response, especially for the production of type I interferons through the regulation of TRIM25 (show TRIM25 Antibodies)-mediated ubiquitination of RIG-I (show DDX58 Antibodies). .
Matrix metalloproteinase-3 (show MMP3 Antibodies) is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress
CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans
Endoplasmic reticulum stress related factor ATF6 (show ATF6 Antibodies) and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children.
We found that RNA interference-induced Caspase-12 silencing increased NOD1 (show NOD1 Antibodies), hBD1 (show DEFB1 Antibodies) and hBD2 (show DEFB4 Antibodies) expression
EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis.
Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores.
CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection.
examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product
caspase 12 has acquired deleterious mutations
Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion (show PRNP Antibodies) disorders.
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
, caspase 12 pseudogene 1
, inactive caspase-12