Browse our anti-Caspase 12 (CASP12) Antibodies

Full name:
anti-Caspase 12 (Gene/pseudogene) Antibodies (CASP12)
On are 24 Caspase 12 (Gene/pseudogene) (CASP12) Antibodies from 10 different suppliers available. Additionally we are shipping Caspase 12 Kits (6) and and many more products for this protein. A total of 32 Caspase 12 products are currently listed.
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CASP12 120329

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anti-Human Caspase 12 Antibodies:

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Top referenced anti-Caspase 12 Antibodies

  1. Human Polyclonal Caspase 12 Primary Antibody for WB - ABIN306744 : Nakagawa, Zhu, Morishima, Li, Xu, Yankner, Yuan: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. in Nature 2000 (PubMed)
    Show all 3 references for 306744

  2. Human Polyclonal Caspase 12 Primary Antibody for WB - ABIN306745 : Mehmet: Caspases find a new place to hide. in Nature 2000 (PubMed)
    Show all 3 references for 306745

More Antibodies against Caspase 12 Interaction Partners

Human Caspase 12 (Gene/pseudogene) (CASP12) interaction partners

  1. Endoplasmic reticulum stress related factor ATF6 (show ATF6 Antibodies) and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.

  2. Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children.

  3. We found that RNA interference-induced Caspase-12 silencing increased NOD1 (show NOD1 Antibodies), hBD1 (show DEFB1 Antibodies) and hBD2 (show DEFB4 Antibodies) expression

  4. EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis.

  5. Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores.

  6. CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection.

  7. examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product

  8. caspase 12 has acquired deleterious mutations

  9. Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion (show PRNP Antibodies) disorders.

  10. Na/Ca exchanger (show SLC8A1 Antibodies) overexpression activates caspase-12

Caspase 12 (CASP12) Antigen Profile

Antigen Summary

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Alternative names and synonyms associated with Caspase 12 (CASP12)

  • caspase 12 (gene/pseudogene) (CASP12) antibody
  • CASP-12 antibody
  • CASP12P1 antibody

Protein level used designations for CASP12

caspase 12 pseudogene 1 , inactive caspase-12

120329 Homo sapiens
100506742 Homo sapiens
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