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anti-Human Caspase 12 Antibodies:
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Human Polyclonal Caspase 12 Primary Antibody for WB - ABIN306744
Nakagawa, Zhu, Morishima, Li, Xu, Yankner, Yuan: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. in Nature 2000
Show all 3 references for ABIN306744
Human Polyclonal Caspase 12 Primary Antibody for WB - ABIN306745
Mehmet: Caspases find a new place to hide. in Nature 2000
Show all 3 references for ABIN306745
Endoplasmic reticulum stress related factor ATF6 (show ATF6 Antibodies) and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children.
We found that RNA interference-induced Caspase-12 silencing increased NOD1 (show NOD1 Antibodies), hBD1 (show DEFB1 Antibodies) and hBD2 (show DEFB4 Antibodies) expression
EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis.
Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores.
CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection.
examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product
caspase 12 has acquired deleterious mutations
Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion (show PRNP Antibodies) disorders.
Na/Ca exchanger (show SLC8A1 Antibodies) overexpression activates caspase-12
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
caspase 12 pseudogene 1
, inactive caspase-12