Browse our Caspase 4 Proteins (CASP4)

Full name:
Caspase 4, Apoptosis-Related Cysteine Peptidase Proteins (CASP4)
On are 25 Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Proteins from 7 different suppliers available. Additionally we are shipping Caspase 4 Antibodies (263) and Caspase 4 Kits (54) and many more products for this protein. A total of 358 Caspase 4 products are currently listed.
CASP1, CASP4, Casp11, CASP13, Caspl, ICE(rel)II, ICEREL-II, ICH-2, ich-3, Mih1/TX, TX
list all proteins Gene Name GeneID UniProt
CASP4 837 P49662
CASP4 12363 P70343
Rat CASP4 CASP4 114555  

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Caspase 4 Proteins (CASP4) by Origin

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Top referenced Caspase 4 Proteins

  1. Human Caspase 4 Protein expressed in Escherichia coli (E. coli) - ABIN2487273 : Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009 (PubMed)
    Show all 4 references for 2487273

More Proteins for Caspase 4 Interaction Partners

Human Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) interaction partners

  1. Pathophysiological studies showed that the overexpression of the CASP4 gene was involved in the loss of proximal tubules and renal injury in nephropathic cystinosis patients. Considering kidney's key roles in sodium filtration and reabsorption CASP4 genes are involved in Blood Pressure regulation.

  2. We propose that microglial caspase-4 expression contributes to the cognitive impairments in Alzheimer's disease (AD), and that further study of caspase-4 will enhance our understanding of AD pathogenesis and may lead to novel therapeutic targets in AD.

  3. this study shows that activation of caspase-4 is mediated by interactions with endotoxin-rich membrane interfaces rather than by endotoxin monomers

  4. Specific activation of caspase-3 (show CASP3 Proteins) and caspase-4 was found in proplatelets. Consistent with previous observations of caspase-4 autoactivation in response to endoplasmic reticulum (ER) stress, several ER stress marker proteins were expressed during proplatelet formation.

  5. apoptosis is induced by rhein traditional Chinese medicine via induction of endoplasmic reticulum stress, caspase-4 and intracellular calcium in primary human hepatic HL-7702 cells

  6. Caspase-4 and caspase-5 (show CASP5 Proteins) mediate IL-1alpha and IL-1beta (show IL1B Proteins) release from human monocytes after lipopolysaccharides stimulation.

  7. both caspase-4 and caspase-5 (show CASP5 Proteins) are functionally important for appropriate responses to intracellular Gram-negative bacteria.

  8. caspase-4 activation alone is sufficient to induce pyroptosis, this process depends on the NLRP3 (show NLRP3 Proteins) inflammasome activation to drive IL-1beta (show IL1B Proteins) maturation.

  9. This study reveled that CASP4 having a central role in the bipolar disease and schizophrenia manifestation.

  10. NF-kappaB (show NFKB1 Proteins) can mediate Fas (show FAS Proteins)-induced apoptosis through caspase-4 protease

Mouse (Murine) Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) interaction partners

  1. Caspase-11 targets cofilin (show CFL1 Proteins) via the RhoA GTPase, whereas caspase-1 (show CASP1 Proteins) engages the Slingshot phosphatase

  2. Hyperactive dendritic cells induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxidized phospholipids and bacterial lipopolysaccharide.

  3. Caspase-1 (show CASP1 Proteins)-activated IL-18 (show IL18 Proteins) induces IFN-gamma (show IFNG Proteins) to prime caspase-11 and rapidly clear Burkholderia thailandensis infection.

  4. These results argue that caspase-1 (show CASP1 Proteins), -4 or -5 can be recruited to inflammasomes under specific circumstances, often leading to distinctly organized and localized complexes that may impact the functions of these proteases

  5. gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation

  6. But not in Casp11(-/-), Panx1 (show PANX1 Proteins)(-/-), or P2x7 (show P2RX7 Proteins)(-/-) mice.

  7. active caspase-11 leads to a drop of intracellular potassium levels, which is necessary to activate NLRP3 (show NLRP3 Proteins).

  8. Data show that caspase-1 (show CASP1 Proteins) but not caspase-11 was essential for the functional activities of the NLRC4 (show NLRC4 Proteins) inflammasome.

  9. Data indicate that genetic ablation of caspase-1 and -11 from cpdm mice significantly reduced skin inflammation in sharpin-deficient mice.

  10. These results suggest a role for other caspase-11 effector mechanisms such as pyroptosis in protection against intestinal inflammation.

Caspase 4 (CASP4) Protein Profile

Protein Summary

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Caspase 4 (CASP4)

  • caspase 4 (CASP4)
  • caspase 11 (LOC100101589)
  • caspase 4, apoptosis-related cysteine peptidase (CASP4)
  • caspase 4, apoptosis-related cysteine peptidase (Casp4)
  • caspase-4-like (LOC100359184)
  • CASP1 protein
  • CASP4 protein
  • Casp11 protein
  • CASP13 protein
  • Caspl protein
  • ICE(rel)II protein
  • ICEREL-II protein
  • ICH-2 protein
  • ich-3 protein
  • Mih1/TX protein
  • TX protein

Protein level used designations for CASP4

caspase 4 , CASP-4 , ICE(rel)-II , apoptotic cysteine protease Mih1/TX , caspase 4, apoptosis-related cysteine protease , caspase-4 , protease ICH-2 , protease TX , CASP-11 , caspase 11, apoptosis-related cysteine peptidase , caspase 11, apoptosis-related cysteine protease , caspase-11 short form splicing , protease ICH-3 , caspase 11 , CASP-1 , ICE , IL-1 beta-converting enzyme , IL-1BC , caspase-1 , caspase-1/caspase-4 hybrid , interleukin-1 beta convertase , interleukin-1 beta-converting enzyme , p45 , CASP-13 , ERICE , caspase 13 , caspase-13 , evolutionary related interleukin-1-beta-converting enzyme

704864 Macaca mulatta
100101589 Oryctolagus cuniculus
837 Homo sapiens
12363 Mus musculus
114555 Rattus norvegicus
403724 Canis lupus familiaris
338039 Bos taurus
100359184 Oryctolagus cuniculus
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