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Caspase 4 Products

(Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].

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Featured Caspase 4 Categories

Caspase 4 Antibodies

High quality antibodies with extensive validation data.

Caspase 4 ELISA Kits

Reliable ELISA kits for a wide range of species.

Caspase 4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Caspase 4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (4)
Cat. No. ABIN1326998
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (3)
Cat. No. ABIN7438061
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (3)
Cat. No. ABIN7146946
Quantity 100 μg
Datasheet Datasheet

Recommended Caspase 4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6954420
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965468
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965467
Quantity 96 tests
Datasheet Datasheet

Recommended Caspase 4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122167
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348107
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7394738
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Caspase 4 products

Quach, Moreau, Sandall, Chadee: "Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D." in: Mucosal immunology, Vol. 12, Issue 2, pp. 323-339, (2019) (PubMed).

Wang, Lim, Kajikawa, Li, Vallance, Moutsopoulos, Chavakis, Hajishengallis: "Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis." in: Cell reports, Vol. 26, Issue 6, pp. 1614-1626.e5, (2019) (PubMed).

Pronin, Pham, An, Dvoriantchikova, Reshetnikova, Qiao, Kozhekbaeva, Reiser, Slepak, Shestopalov: "Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury." in: Frontiers in molecular neuroscience, Vol. 12, pp. 36, (2019) (PubMed).

Liu, Zhang, Sun, Guo, Zhou: "E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation." in: Cell death and differentiation, (2019) (PubMed).

Kayagaki, Lee, Stowe, Kornfeld, ORourke, Mirrashidi, Haley, Watanabe, Roose-Girma, Modrusan, Kummerfeld, Reja, Zhang, Cho, Andrews, Morris, Goodnow, Bertram, Dixit: "IRF2 transcriptionally induces GSDMD expression for pyroptosis." in: Science signaling, Vol. 12, Issue 582, (2019) (PubMed).

Li, Wu, Yang, Wu, Ma, Liu, Moynagh, Wang, Hu, Yang: "Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis." in: The Journal of experimental medicine, Vol. 216, Issue 11, pp. 2562-2581, (2019) (PubMed).

Chen, Wang, Lai, Braunstein, He, Ruan, Yin, Wang, Cianflone, Ning, Chen, Wang: "Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration." in: Frontiers in immunology, Vol. 9, pp. 2015, (2019) (PubMed).

Castejon, Sánchez-Hidalgo, Aparicio-Soto, Montoya, Martín-LaCave, Fernández-Bolaños, Alarcón-de-la-Lastra: "Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-κB, MAPK and NLRP3 inflammasome signaling pathways." in: The Journal of nutritional biochemistry, Vol. 74, pp. 108229, (2019) (PubMed).

Kolb, Phan, Borcherding, Liu, Yuan, Janowski, Xie, Markan, Li, Potthoff, Fuentes-Mattei, Ellies, Knudson, Lee, Yeung, Cassel, Sutterwala, Zhang: "Obesity-associated NLRC4 inflammasome activation drives breast cancer progression." in: Nature communications, Vol. 7, pp. 13007, (2018) (PubMed).

Deigendesch, Zychlinsky, Meissner: "Copper Regulates the Canonical NLRP3 Inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 5, pp. 1607-1617, (2018) (PubMed).

Synonyms and alternative names related to Caspase 4

caspase 4 (CASP4), caspase 4 (Casp4), caspase 4, apoptosis-related cysteine peptidase (CASP4), caspase 4, apoptosis-related cysteine peptidase (Casp4), caspase-4 (LOC100731032), CASP1, CASP4, Casp4, Casp11, CASP13, Caspl, ICE(rel)II, ICEREL-II, ICH-2, ich-3, Mih1/TX, TX

Protein level used designations for Caspase 4

  • CASP-4
  • ICE(rel)-II
  • apoptotic cysteine protease Mih1/TX
  • caspase 4, apoptosis-related cysteine protease
  • caspase-4
  • protease ICH-2
  • protease TX
  • caspase 11
  • caspase 4
  • CASP-13
  • ERICE
  • caspase 13
  • caspase-13
  • evolutionary related interleukin-1-beta-converting enzyme
  • CASP-1
  • ICE
  • IL-1 beta-converting enzyme
  • IL-1BC
  • caspase-1
  • caspase-1/caspase-4 hybrid
  • interleukin-1 beta convertase
  • interleukin-1 beta-converting enzyme
  • p45
  • CASP-11
  • caspase 11, apoptosis-related cysteine peptidase
  • caspase 11, apoptosis-related cysteine protease
  • caspase-11 short form splicing
  • protease ICH-3
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
  • caspase 4, apoptosis-related cysteine peptidase
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