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Browse our Caspase 8 Proteins (CASP8)

Full name:
Caspase 8, Apoptosis-Related Cysteine Peptidase Proteins (CASP8)
On www.antibodies-online.com are 24 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Proteins from 8 different suppliers available. Additionally we are shipping Caspase 8 Antibodies (386) and Caspase 8 Kits (64) and many more products for this protein. A total of 496 Caspase 8 products are currently listed.
Synonyms:
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
list all proteins Gene Name GeneID UniProt
CASP8 12370 O89110
Rat CASP8 CASP8 64044  
CASP8 841 Q14790

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Caspase 8 Proteins (CASP8) by Origin

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Top referenced Caspase 8 Proteins

  1. Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2487286 : Appukuttan, Kasseckert, Micoogullari, Flacke, Kumar, Woste, Abdallah, Pott, Reusch, Ladilov: Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. in Cardiovascular research 2012 (PubMed)
    Show all 6 references for ABIN2487286

  2. Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2688831 : Nicholson, Ali, Thornberry, Vaillancourt, Ding, Gallant, Gareau, Griffin, Labelle, Lazebnik: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. in Nature 1995 (PubMed)
    Show all 3 references for ABIN2688831

  3. Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2688834 : Patel, Gores, Kaufmann: The role of proteases during apoptosis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996 (PubMed)
    Show all 3 references for ABIN2688834

More Proteins for Caspase 8 Interaction Partners

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (show AMD1 Proteins)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (show TP53 Proteins)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID Proteins) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. studies have uncovered the combined actions of the NLRP3 (show NLRP3 Proteins) inflammasome and caspase 8 leading to IL-1beta (show IL1B Proteins) maturation and the directionality of IL-1beta (show IL1B Proteins) in driving disease inPstpip2(cmo (show PSTPIP2 Proteins))mice.

  2. Chronic TLR Stimulation Controls NLRP3 (show NLRP3 Proteins) Inflammasome Activation through IL-10 (show IL10 Proteins) Mediated Regulation of NLRP3 (show NLRP3 Proteins) Expression and Caspase-8 Activation

  3. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  4. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (show RIPK3 Proteins)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (show LYZ Proteins) M) Casp8fl/fl (caspase 8) mice.

  5. CASP8 deletion did not affect the overall number of microglia expressing the pan specific microglia marker, Iba1 (show AIF1 Proteins)

  6. We observed that NDMP generation was dependent on the extrinsic caspase (show CASP3 Proteins) apoptotic pathway (caspase 3 (show CASP3 Proteins) and caspase 8), cAMP activation of PKA but not of Epac (show RAPGEF3 Proteins), and on activation of MLCK (show MYLK Proteins).

  7. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 (show CASP1 Proteins) and the Noncanonical Caspase-8 Inflammasomes.

  8. Casp8-dependent migration of enterocytes is likely involved in intestinal physiology and inflammation-related pathophysiology.

  9. NLRP3 (show NLRP3 Proteins) inflammasomes directly utilize caspase-8 as both a pro-apoptotic initiator and major IL-1beta (show IL1B Proteins)-converting protease

  10. The non-receptor tyrosine kinase (show TNK1 Proteins) Tec (show NR4A3 Proteins) controls assembly and activity of the noncanonical caspase-8 inflammasome.

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Excessive TLR9 (show TLR9 Proteins) signaling contributed to maternal-fetal tolerance disruption via an effect on Treg cell survival by activation of Caspase 8/3

  2. Data show that when death receptor 5 (DR5 (show TNFRSF10B Proteins)) is suppressed, caspase-8 may recruit and stabilize TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Proteins)) to form a metastasis and invasion signaling complex, resulting in activation of ERK (show EPHB2 Proteins) signaling.

  3. we conclude that some SNPs in CASP8 are associated with subtype-specific breast cancer risk. This study contributes to our understanding of CASP8 SNPs and breast cancer risk by subtype.

  4. Frequencies of SNPs rs2234978 and rs1045487 of FAS (show FAS Proteins) and CASP8 genes were significantly higher in Autoimmune Lymphoproliferative Syndrome patients.

  5. procaspase-8:c-FLIPL (show CFLAR Proteins) exhibits localized enzymatic activity and is preferentially an activator, promoting DED (show AATF Proteins)-mediated procaspase-8 oligomer assembly, whereas procaspase-8:c-FLIPS (show CFLAR Proteins) lacks activity and potently blocks procaspase-8 activation

  6. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  7. HER2 (show ERBB2 Proteins) promotes tumor cell survival by inhibiting apoptosis i.e. by downregulating CASP-3 (show CASP3 Proteins) and CASP-8.

  8. Studied the mechanism of Artemisinin (ARTE)-induced human lung adenocarcinoma (ASTC-a-1) cell apoptosis; results showed ARTE induced the activation of caspase-3 (show CASP3 Proteins), -8 and -9.

  9. ASC (show PYCARD Proteins) induces procaspase-8 death effector domain filaments

  10. A frame-shift and a novel missense mutation in CASP8 gene is associated with oral Squamous Cell Carcinoma.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (show CASP3 Proteins) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (show CASP9 Proteins).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (show STAT1 Proteins) at Ser (show SIGLEC1 Proteins)-727 and STAT1 (show STAT1 Proteins) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (show BCL2L1 Proteins).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Targeted gene knockdown of TNFRSF1B (show TNFRSF1B Proteins) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (show CASP2 Proteins) and P53 (show TP53 Proteins)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Proteins).

  2. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) Protein Profile

Protein Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8)
  • death related ced-3/Nedd2-like protein (Dredd)
  • caspase 8, apoptosis-related cysteine peptidase (CASP8)
  • caspase-8 (AaeL_AAEL014148)
  • caspase-8 (casp8)
  • caspase 8 (LOC100222284)
  • caspase 8 (Casp8)
  • caspase 8 (LOC100348477)
  • ALPS2B protein
  • CAP4 protein
  • Casp-8 protein
  • CASP8 protein
  • casp8-A protein
  • caspase-8 protein
  • FLICE protein
  • MACH protein
  • MCH5 protein
  • xCaspase-8 protein
  • zgc:92075 protein

Protein level used designations for CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

GENE ID SPECIES
373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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