Browse our Caspase 8 Proteins (CASP8)

Full name:
Caspase 8, Apoptosis-Related Cysteine Peptidase Proteins (CASP8)
On www.antibodies-online.com are 29 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Proteins from 8 different suppliers available. Additionally we are shipping Caspase 8 Antibodies (397) and Caspase 8 Kits (70) and many more products for this protein. A total of 518 Caspase 8 products are currently listed.
Synonyms:
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
list all proteins Gene Name GeneID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

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Caspase 8 Proteins (CASP8) by Origin

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Top referenced Caspase 8 Proteins

  1. Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2487286 : Appukuttan, Kasseckert, Micoogullari, Flacke, Kumar, Woste, Abdallah, Pott, Reusch, Ladilov: Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. in Cardiovascular research 2012 (PubMed)
    Show all 6 references for 2487286

  2. Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2688834 : Nicholson, Ali, Thornberry, Vaillancourt, Ding, Gallant, Gareau, Griffin, Labelle, Lazebnik: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. in Nature 1995 (PubMed)
    Show all 3 references for 2688834

  3. Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2688831 : Patel, Gores, Kaufmann: The role of proteases during apoptosis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996 (PubMed)
    Show all 3 references for 2688831

More Proteins for Caspase 8 Interaction Partners

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (show AMD1 Proteins)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (show TP53 Proteins)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID Proteins) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Statistically significant increases in the expression of Fas (show FAS Proteins) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (show DAPK1 Proteins), Traf3 (show TRAF3 Proteins), Tnsf12, Tnfrsf1A (show TNFRSF1A Proteins) and Ripk1 (show RIPK1 Proteins).

  2. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (show RIPK3 Proteins))-mediated necroptosis.

  3. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

  4. Data indicate that NLRC4 (show NLRC4 Proteins) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (show IL18 Proteins) release, and implicate Caspase-8 in NLRC4 (show NLRC4 Proteins) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (show CASP1 Proteins) and Caspase-8.

  5. ING4 (show ING4 Proteins) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (show FAS Proteins)-induced apoptosis in a caspase-8-dependent pathway.

  6. studies have uncovered the combined actions of the NLRP3 (show NLRP3 Proteins) inflammasome and caspase 8 leading to IL-1beta (show IL1B Proteins) maturation and the directionality of IL-1beta (show IL1B Proteins) in driving disease inPstpip2(cmo (show PSTPIP2 Proteins))mice.

  7. Chronic TLR Stimulation Controls NLRP3 (show NLRP3 Proteins) Inflammasome Activation through IL-10 (show IL10 Proteins) Mediated Regulation of NLRP3 (show NLRP3 Proteins) Expression and Caspase-8 Activation

  8. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  9. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (show RIPK3 Proteins)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (show LYZ Proteins) M) Casp8fl/fl (caspase 8) mice.

  10. CASP8 deletion did not affect the overall number of microglia expressing the pan specific microglia marker, Iba1 (show AIF1 Proteins)

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Insertion genotype of CASP8 rs3834129 polymorphisms showed risk in CAD. CASP8 rs3769818 activates intronic cryptic donor.

  2. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase (show KARS Proteins) in exosomes from colorectal cancer cells.

  3. Fisetin inhibited Triple-Negative Breast Cancer Cells cell division and induced apoptosis, which was associated with mitochondrial membrane permeabilization and the activation of caspase-9 (show CASP9 Proteins) and caspase-8, as well as the cleavage of poly(ADP-ribose) polymerase-1 (show PARP1 Proteins).

  4. Caspase-8 can serve in two distinct roles in response to TRAIL receptor engagement, as a scaffold for assembly of a Caspase-8-FADD-RIPK1 "FADDosome" complex, leading to NFkappaB-dependent inflammation, or as a protease that promotes apoptosis.

  5. Using the tDED filament structure as a template, structural analyses reveal the interaction surfaces between FADD (show FADD Proteins) and caspase-8 and the distinct mechanisms of regulation by cFLIP (show CFLAR Proteins) and MC159 through comingling and capping, respectively.

  6. our novel findings expand our understanding of the key mechanisms underlying the anti-apoptotic functions of caspase-8 which may act as a critical block to existing antitumour therapies.

  7. Proteases caspase-1 (show CASP1 Proteins) and caspase-8 have redundant roles in cleaving IL-1beta (show IL1B Proteins) and promoting osteomyelitis. [review]

  8. Dasatinib, a c-Src (show SRC Proteins) inhibitor, dephosphorylated caspase-8 to facilitate necroptosis, rather than apoptosis, in paclitaxel-treated p-Casp8-expressing lung adenocarcinoma cells.

  9. Loss of function mutations in FAT1 and CASP8 prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines.

  10. Dysregulation of a potassium channel (show KCNAB2 Proteins), THIK-1 (show KCNK13 Proteins), targeted by caspase-8, accelerates cell shrinkage.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (show CASP3 Proteins) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (show CASP9 Proteins).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (show STAT1 Proteins) at Ser (show SIGLEC1 Proteins)-727 and STAT1 (show STAT1 Proteins) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (show BCL2L1 Proteins).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Induction of apoptosis through targeted activation of caspase (show CASP3 Proteins) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.

  2. Targeted gene knockdown of TNFRSF1B (show TNFRSF1B Proteins) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (show CASP2 Proteins) and P53 (show TP53 Proteins)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Proteins).

  3. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) Protein Profile

Protein Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8)
  • death related ced-3/Nedd2-like protein (Dredd)
  • caspase 8, apoptosis-related cysteine peptidase (CASP8)
  • caspase-8 (AaeL_AAEL014148)
  • caspase-8 (casp8)
  • caspase 8 (LOC100222284)
  • caspase 8 (Casp8)
  • caspase 8 (LOC100348477)
  • ALPS2B protein
  • CAP4 protein
  • Casp-8 protein
  • CASP8 protein
  • casp8-A protein
  • caspase-8 protein
  • FLICE protein
  • MACH protein
  • MCH5 protein
  • xCaspase-8 protein
  • zgc:92075 protein

Protein level used designations for CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

GENE ID SPECIES
373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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