Browse our anti-DIABLO (DIABLO) Antibodies

On are 197 Second Mitochondria-Derived Activator of Caspase (DIABLO) Antibodies from 30 different suppliers available. Additionally we are shipping DIABLO Kits (24) and DIABLO Proteins (20) and many more products for this protein. A total of 251 DIABLO products are currently listed.
0610041G12Rik, 1700006L01Rik, AU040403, DBO, DFNA64, diablo-s, SMAC, smac3, XSmac
list all antibodies Gene Name GeneID UniProt
DIABLO 56616 Q9NR28
DIABLO 288753  

Most Popular Reactivities for anti-DIABLO (DIABLO) Antibodies

anti-Mouse (Murine) DIABLO Antibodies:

anti-Human DIABLO Antibodies:

anti-Rat (Rattus) DIABLO Antibodies:

All available anti-DIABLO Antibodies

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More Antibodies against DIABLO Interaction Partners

Mouse (Murine) Second Mitochondria-Derived Activator of Caspase (DIABLO) interaction partners

  1. We report that an Smac-mimetic selectively induces TNF-alpha (show TNF Antibodies)-dependent cystic renal epithelial cell death, leading to the removal of cystic epithelial cells from renal tissues and delaying cyst formation.

  2. Results demonstrate an essential and apoptosis-independent function of SMAC in tumor suppression and provide new insights into the biology and targeting of colon cancer.

  3. Identification of a novel anti-apoptotic E3 ubiquitin ligase (show MUL1 Antibodies) that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2 (show HTRA2 Antibodies), and ARTS.

  4. Loss of Smac/DIABLO alters both caspase (show CASP3 Antibodies)-dependent and caspase (show CASP3 Antibodies)-independent intrinsic programmed cell death.

  5. Membrane-associated XIAP (show XIAP Antibodies) induces mitochondrial outer membrane permeabilization leading to cytochrome c (show CYCS Antibodies) and Smac release, which is dependent on Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies).

  6. data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function.

  7. mitochondrial activation by Bid (show BID Antibodies) is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release

  8. Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV.

  9. Transient focal ischemia was produced for 1 hour in mice. Mitochondrial levels of DIABLO increased after 2-11 h reperfusion. DIABLO increased in the cytosol after 5 h reperfusion, implying the translocation of DIABLO into the cytosol.

  10. Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies) differentially regulate the release of cytochrome c (show CYCS Antibodies) and Smac/DIABLO from mitochondria, and Smac/DIABLO can be used to sensitize cells that are deficient in Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies) genes, or resistant to TRAIL.

Human Second Mitochondria-Derived Activator of Caspase (DIABLO) interaction partners

  1. Expressions of SDF-1 (show CXCL12 Antibodies), survivin (show BIRC5 Antibodies) and smac were significantly higher in epithelial ovarian cancer tissue than those in normal tissue.

  2. Results indicate that Smac plays an important role in reticulum stress-induced apoptosis in human lens epithelial cells, suggesting its close association with cataract development.

  3. Smac mimetic APG (show SMAD1 Antibodies)-1387 exerts a potent antitumor effect on nasopharyngeal carcinoma cells by inducing apoptosis.

  4. These results reveal a pro-apoptotic function of PARL (show PARL Antibodies) and identify PARL (show PARL Antibodies)-mediated Smac processing and cytochrome c (show CYCS Antibodies) release facilitated by OPA1 (show OPA1 Antibodies)-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria.

  5. Study found a negative correlation between Smac and XIAP (show XIAP Antibodies) at the level of protein but not mRNA in non-small cell lung carcinoma (NSCLC) patients. Overexpressed XIAP (show XIAP Antibodies) could degrade through ubiquitination, the mature Smac inhibiting NSCLC apoptosis.

  6. Report role of RIP1 (show UQCRFS1 Antibodies) in Smac mimetic mediated chemosensitization of neuroblastoma (show ARHGEF16 Antibodies) cells.

  7. This review discusses the promise as well as some challenges at the translational interface of exploiting Smac mimetics as cancer therapeutics.

  8. Data indicate that Smac/DIABLO showed an inverse correlation with inhibitor of apoptosis proteins XIAP (show XIAP Antibodies), cIAP-1 (show BIRC2 Antibodies) and cIAP-2 (show BIRC3 Antibodies).

  9. Data show that mitochondrial X-linked inhibitor of apoptosis protein (XIAP (show XIAP Antibodies)) entry requires apoptosis regulatory proteins Bax (show BAX Antibodies) or Bak (show BAK1 Antibodies) through mitochondrial permeabilization and Smac/DIABLO protein degradation.

  10. SapC-DOPS acts through a mitochondria-mediated pathway accompanied by an early release of Smac and Bax (show BAX Antibodies).

Xenopus laevis Second Mitochondria-Derived Activator of Caspase (DIABLO) interaction partners

  1. hyperosmotic shock induces rapid calpain activation and high levels of Smac/DIABLO release from the mitochondria before significant amounts of cytochrome c (show CYCS Antibodies) are released to promote caspase-3 (show CASP3 Antibodies) activation

  2. Identification of the third vertebrate homologue of Smac/DIABLO.

DIABLO Antigen Profile

Antigen Summary

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.

Alternative names and synonyms associated with DIABLO

  • diablo, IAP-binding mitochondrial protein (diablo) antibody
  • diablo homolog (Drosophila) (Diablo) antibody
  • diablo, IAP-binding mitochondrial protein (DIABLO) antibody
  • diablo, IAP-binding mitochondrial protein (Diablo) antibody
  • 0610041G12Rik antibody
  • 1700006L01Rik antibody
  • AU040403 antibody
  • DBO antibody
  • DFNA64 antibody
  • diablo-s antibody
  • SMAC antibody
  • smac3 antibody
  • XSmac antibody

Protein level used designations for DIABLO

Direct IAP-binding protein with low pI , diablo homolog, mitochondrial , second mitochondria-derived activator of caspase , direct IAP binding protein with low PI , direct IAP-binding protein with low pI , diablo homolog , mitochondrial diablo-like protein , mitochondrial diablo , second mitochondrial derived activator of caspases , Second mitochondria-derived activator of caspase

549035 Xenopus (Silurana) tropicalis
66593 Mus musculus
56616 Homo sapiens
288753 Rattus norvegicus
477463 Canis lupus familiaris
100155744 Sus scrofa
493999 Bos taurus
100049147 Xenopus laevis
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