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Browse our anti-DIABLO (DIABLO) Antibodies

Full name:
anti-Second Mitochondria-Derived Activator of Caspase Antibodies (DIABLO)
On www.antibodies-online.com are 187 Second Mitochondria-Derived Activator of Caspase (DIABLO) Antibodies from 29 different suppliers available. Additionally we are shipping DIABLO Proteins (18) and DIABLO Kits (13) and many more products for this protein. A total of 227 DIABLO products are currently listed.
Synonyms:
0610041G12Rik, 1700006L01Rik, AU040403, DBO, DFNA64, diablo-s, SMAC, smac3, XSmac
list all antibodies Gene Name GeneID UniProt
DIABLO 66593 Q9JIQ3
DIABLO 56616 Q9NR28
DIABLO 288753  

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Most Popular Reactivities for anti-DIABLO (DIABLO) Antibodies

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anti-Mouse (Murine) DIABLO Antibodies:

anti-Human DIABLO Antibodies:

anti-Rat (Rattus) DIABLO Antibodies:

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Top referenced anti-DIABLO Antibodies

  1. Human Polyclonal DIABLO Primary Antibody for WB - ABIN400971 : Du, Fang, Li, Li, Wang: Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. in Cell 2000 (PubMed)
    Show all 7 references for ABIN400971

  2. Human Monoclonal DIABLO Primary Antibody for WB - ABIN393216 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN393216

  3. Dog (Canine) Monoclonal DIABLO Primary Antibody for IF, WB - ABIN968785 : Chai, Du, Wu, Kyin, Wang, Shi: Structural and biochemical basis of apoptotic activation by Smac/DIABLO. in Nature 2000 (PubMed)
    Show all 4 references for ABIN968785

  4. Human Polyclonal DIABLO Primary Antibody for ELISA, WB - ABIN1996479 : Korga, Korobowicz, Dudka: [Role of mitochondrial protein Smac/Diablo in regulation of apoptotic pathways]. in Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 2006 (PubMed)
    Show all 2 references for ABIN1996479

  5. Human Polyclonal DIABLO Primary Antibody for IHC, WB - ABIN223042 : Haudek, Taffet, Schneider, Mann: TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. in The Journal of clinical investigation 2007 (PubMed)
    Show all 2 references for ABIN223042

  6. Human Polyclonal DIABLO Primary Antibody for IF (p), IHC (p) - ABIN674619 : Liu, Chen, Li, Wang, Cheng: Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts. in International journal of molecular medicine 2013 (PubMed)

  7. Cow (Bovine) Polyclonal DIABLO Primary Antibody for WB - ABIN2792127 : Samuel, Welsh, Lober, Togo, Zapata, Reed: Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against DIABLO Interaction Partners

Mouse (Murine) Second Mitochondria-Derived Activator of Caspase (DIABLO) interaction partners

  1. We report that an Smac-mimetic selectively induces TNF-alpha (show TNF Antibodies)-dependent cystic renal epithelial cell death, leading to the removal of cystic epithelial cells from renal tissues and delaying cyst formation.

  2. Results demonstrate an essential and apoptosis-independent function of SMAC in tumor suppression and provide new insights into the biology and targeting of colon cancer.

  3. Identification of a novel anti-apoptotic E3 ubiquitin ligase (show MUL1 Antibodies) that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2 (show HTRA2 Antibodies), and ARTS.

  4. Loss of Smac/DIABLO alters both caspase (show CASP3 Antibodies)-dependent and caspase (show CASP3 Antibodies)-independent intrinsic programmed cell death.

  5. Membrane-associated XIAP (show XIAP Antibodies) induces mitochondrial outer membrane permeabilization leading to cytochrome c (show CYCS Antibodies) and Smac release, which is dependent on Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies).

  6. data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function.

  7. mitochondrial activation by Bid (show BID Antibodies) is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release

  8. Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV.

  9. Transient focal ischemia was produced for 1 hour in mice. Mitochondrial levels of DIABLO increased after 2-11 h reperfusion. DIABLO increased in the cytosol after 5 h reperfusion, implying the translocation of DIABLO into the cytosol.

  10. Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies) differentially regulate the release of cytochrome c (show CYCS Antibodies) and Smac/DIABLO from mitochondria, and Smac/DIABLO can be used to sensitize cells that are deficient in Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies) genes, or resistant to TRAIL.

Human Second Mitochondria-Derived Activator of Caspase (DIABLO) interaction partners

  1. Report role of RIP1 (show UQCRFS1 Antibodies) in Smac mimetic mediated chemosensitization of neuroblastoma (show ARHGEF16 Antibodies) cells.

  2. This review discusses the promise as well as some challenges at the translational interface of exploiting Smac mimetics as cancer therapeutics.

  3. Data indicate that Smac/DIABLO showed an inverse correlation with inhibitor of apoptosis proteins XIAP (show XIAP Antibodies), cIAP-1 (show BIRC2 Antibodies) and cIAP-2 (show BIRC3 Antibodies).

  4. Data show that mitochondrial X-linked inhibitor of apoptosis protein (XIAP (show XIAP Antibodies)) entry requires apoptosis regulatory proteins Bax (show BAX Antibodies) or Bak (show BAK1 Antibodies) through mitochondrial permeabilization and Smac/DIABLO protein degradation.

  5. SapC-DOPS acts through a mitochondria-mediated pathway accompanied by an early release of Smac and Bax (show BAX Antibodies).

  6. this is the first demonstration that a dual approach using simultaneous overexpression of a cell penetrable form of Smac and TRAIL sensitize and promote apoptotic process even in resistant breast cancer cells.

  7. Preoperative measurement of serum VEGF (show VEGFA Antibodies), survivin (show BIRC5 Antibodies), and Smac/DIABLO may be of help in early detection of serous ovarian cancer and may provide important information about the patient's outcome and prognosis.

  8. Smac-DIABLO adopts a tetrameric assembly in solution.

  9. IRF1 (show IRF1 Antibodies) is a dual regulator of BV6-induced apoptosis and inflammatory cytokine secretion.

  10. CLIC4 (show CLIC4 Antibodies), ERp29 (show ERP29 Antibodies), and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer.

Xenopus laevis Second Mitochondria-Derived Activator of Caspase (DIABLO) interaction partners

  1. hyperosmotic shock induces rapid calpain activation and high levels of Smac/DIABLO release from the mitochondria before significant amounts of cytochrome c (show CYCS Antibodies) are released to promote caspase-3 (show CASP3 Antibodies) activation

  2. Identification of the third vertebrate homologue of Smac/DIABLO.

DIABLO Antigen Profile

Antigen Summary

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.

Alternative names and synonyms associated with DIABLO

  • diablo, IAP-binding mitochondrial protein (diablo) antibody
  • diablo homolog (Drosophila) (Diablo) antibody
  • diablo, IAP-binding mitochondrial protein (DIABLO) antibody
  • diablo, IAP-binding mitochondrial protein (Diablo) antibody
  • 0610041G12Rik antibody
  • 1700006L01Rik antibody
  • AU040403 antibody
  • DBO antibody
  • DFNA64 antibody
  • diablo-s antibody
  • SMAC antibody
  • smac3 antibody
  • XSmac antibody

Protein level used designations for DIABLO

Direct IAP-binding protein with low pI , diablo homolog, mitochondrial , second mitochondria-derived activator of caspase , direct IAP binding protein with low PI , direct IAP-binding protein with low pI , diablo homolog , mitochondrial diablo-like protein , mitochondrial diablo , second mitochondrial derived activator of caspases , Second mitochondria-derived activator of caspase

GENE ID SPECIES
549035 Xenopus (Silurana) tropicalis
66593 Mus musculus
56616 Homo sapiens
288753 Rattus norvegicus
477463 Canis lupus familiaris
100155744 Sus scrofa
493999 Bos taurus
100049147 Xenopus laevis
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