DIABLO antibody (C-Term)

Catalog No. ABIN2792127

This Rabbit Polyclonal antibody specifically detects DIABLO in WB and IHC. It exhibits reactivity toward Human, Cow, Dog, Horse and Pig.

Quick Overview for DIABLO antibody (C-Term) (ABIN2792127)

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Reactivity: Human, Cow, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIABLO antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-DIABLO Antibody

Binding Specificity: C-Term

Purpose: DIABLO Antibody - C-terminal region

Sequence: LVKLQVEEVH QLSRKAETKL AEAQIEELRQ KTQEEGEERA ESEQEAYLRE

Predicted Reactivity: Cow: 85%, Dog: 92%, Horse: 85%, Human: 100%, Pig: 85%

Characteristics: This is a rabbit polyclonal antibody against DIABLO. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DIABLO

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DIABLO

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Alternative Name: DIABLO

Background:

Background Information: DIABLO is an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.

Gene Name: Diablo, IAP-binding mitochondrial protein

Alternative Symbols: SMAC, DFNA64

Protein Name: Diablo homolog (Drosophila) EMBL AAH95468.1

Molecular Weight: 21kDa

Gene ID: 56616

NCBI Accession: NP_620308

UniProt: Q502X2

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity