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DIABLO Products

(Second Mitochondria-Derived Activator of Caspase (DIABLO))

Categories

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008].

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Featured DIABLO Categories

DIABLO Antibodies

High quality antibodies with extensive validation data.

DIABLO ELISA Kits

Reliable ELISA kits for a wide range of species.

DIABLO Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DIABLO Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC, WB
Validations
  • (5)
Cat. No. ABIN7270177
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), ELISA, WB
Validations
  • (1)
  • (4)
Cat. No. ABIN3044515
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF (cc), IHC (p), WB
Validations
  • (1)
  • (3)
Cat. No. ABIN674619
Quantity 100 μL
Datasheet Datasheet

Recommended DIABLO ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN625468
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959278
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959279
Quantity 96 tests
Datasheet Datasheet

Recommended DIABLO Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3130084
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351587
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5570433
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our DIABLO products

Liu, Hu, Li, Cao, Wang, Ma, Li: "Mesenchymal stem cells expressing interleukin-18 inhibit breast cancer in a mouse model." in: Oncology letters, Vol. 15, Issue 5, pp. 6265-6274, (2018) (PubMed).

You, Li, Jin, Zheng, Chen, Yang: "Genistein protects against Aβ25-35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers." in: BMC neuroscience, Vol. 18, Issue 1, pp. 12, (2017) (PubMed).

Hwang, Dornbos, Steidemann, Dunivin, Rizzo, LaPres: "Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome." in: Toxicology and applied pharmacology, (2016) (PubMed).

Sirianni, Jiang, Zeng, Mao, Zhou, Sugarbaker, Zhang, Li, Friedlander, Wang: "N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis." in: Journal of neurochemistry, Vol. 134, Issue 5, pp. 956-68, (2015) (PubMed).

Sulaiman, Chu, Blanco, Vallabhapurapu, Franco, Qi: "SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas." in: Molecular cancer, Vol. 14, pp. 78, (2015) (PubMed).

Abulwerdi, Liao, Liu, Azmi, Aboukameel, Mady, Gulappa, Cierpicki, Owens, Zhang, Sun, Stuckey, Mohammad, Nikolovska-Coleska: "A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo." in: Molecular cancer therapeutics, Vol. 13, Issue 3, pp. 565-75, (2014) (PubMed).

Wiita, Hsu, Lu, Esensten, Wells: "Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 21, pp. 7594-9, (2014) (PubMed).

Liu, Chen, Li, Wang, Cheng: "Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts." in: International journal of molecular medicine, Vol. 32, Issue 3, pp. 615-22, (2013) (PubMed).

Qiu, Liu, Sebastini, Sun, Wang, Zhang, Yu: "An apoptosis-independent role of SMAC in tumor suppression." in: Oncogene, Vol. 32, Issue 19, pp. 2380-9, (2013) (PubMed).

Zhang, Cook, Kim, Baranov, Jiang, Smith, Cormier, Bennett, Browser, Day, Carlisle, Ferrante, Wang, Friedlander: "Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis." in: Neurobiology of disease, Vol. 55, pp. 26-35, (2013) (PubMed).

Synonyms and alternative names related to DIABLO

diablo, IAP-binding mitochondrial protein (diablo), diablo, IAP-binding mitochondrial protein (Diablo), diablo IAP-binding mitochondrial protein (DIABLO), diablo, IAP-binding mitochondrial protein L homeolog (diablo.L), 0610041G12Rik, 1700006L01Rik, AU040403, DBO, DFNA64, diablo-s, smac, Smac, SMAC, smac3, XSmac

Protein level used designations for DIABLO

  • Direct IAP-binding protein with low pI
  • diablo homolog, mitochondrial
  • second mitochondria-derived activator of caspase
  • direct IAP binding protein with low PI
  • direct IAP-binding protein with low pI
  • diablo homolog
  • mitochondrial diablo-like protein
  • mitochondrial diablo
  • second mitochondrial derived activator of caspases
  • Second mitochondria-derived activator of caspase
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