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Human DIABLO ELISA Kit for Sandwich ELISA - ABIN1889324
McNeish, Bell, McKay, Tenev, Marani, Lemoine: Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway. in Experimental cell research 2003
We report that an Smac-mimetic selectively induces TNF-alpha (show TNF ELISA Kits)-dependent cystic renal epithelial cell death, leading to the removal of cystic epithelial cells from renal tissues and delaying cyst formation.
Results demonstrate an essential and apoptosis-independent function of SMAC in tumor suppression and provide new insights into the biology and targeting of colon cancer.
Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2 (show HTRA2 ELISA Kits), and ARTS.
Loss of Smac/DIABLO alters both caspase (show CASP3 ELISA Kits)-dependent and caspase (show CASP3 ELISA Kits)-independent intrinsic programmed cell death.
Membrane-associated XIAP (show XIAP ELISA Kits) induces mitochondrial outer membrane permeabilization leading to cytochrome c (show CYCS ELISA Kits) and Smac release, which is dependent on Bax (show BAX ELISA Kits) and Bak (show BAK1 ELISA Kits).
data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function.
mitochondrial activation by Bid (show BID ELISA Kits) is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release
Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV.
Transient focal ischemia was produced for 1 hour in mice. Mitochondrial levels of DIABLO increased after 2-11 h reperfusion. DIABLO increased in the cytosol after 5 h reperfusion, implying the translocation of DIABLO into the cytosol.
Bax (show BAX ELISA Kits) and Bak (show BAK1 ELISA Kits) differentially regulate the release of cytochrome c (show CYCS ELISA Kits) and Smac/DIABLO from mitochondria, and Smac/DIABLO can be used to sensitize cells that are deficient in Bax (show BAX ELISA Kits) and Bak (show BAK1 ELISA Kits) genes, or resistant to TRAIL.
This review discusses the promise as well as some challenges at the translational interface of exploiting Smac mimetics as cancer therapeutics.
Data indicate that Smac/DIABLO showed an inverse correlation with inhibitor of apoptosis proteins XIAP (show XIAP ELISA Kits), cIAP-1 (show BIRC2 ELISA Kits) and cIAP-2 (show BIRC3 ELISA Kits).
Data show that mitochondrial X-linked inhibitor of apoptosis protein (XIAP (show XIAP ELISA Kits)) entry requires apoptosis regulatory proteins Bax (show BAX ELISA Kits) or Bak (show BAK1 ELISA Kits) through mitochondrial permeabilization and Smac/DIABLO protein degradation.
SapC-DOPS acts through a mitochondria-mediated pathway accompanied by an early release of Smac and Bax (show BAX ELISA Kits).
this is the first demonstration that a dual approach using simultaneous overexpression of a cell penetrable form of Smac and TRAIL sensitize and promote apoptotic process even in resistant breast cancer cells.
Preoperative measurement of serum VEGF (show VEGFA ELISA Kits), survivin (show BIRC5 ELISA Kits), and Smac/DIABLO may be of help in early detection of serous ovarian cancer and may provide important information about the patient's outcome and prognosis.
Smac-DIABLO adopts a tetrameric assembly in solution.
IRF1 (show IRF1 ELISA Kits) is a dual regulator of BV6-induced apoptosis and inflammatory cytokine secretion.
CLIC4 (show CLIC4 ELISA Kits), ERp29 (show ERP29 ELISA Kits), and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer.
Within mitochondria, XIAP (show XIAP ELISA Kits) selectively signals lysosome- and proteasome-associated degradation of its inhibitor Smac.
hyperosmotic shock induces rapid calpain activation and high levels of Smac/DIABLO release from the mitochondria before significant amounts of cytochrome c (show CYCS ELISA Kits) are released to promote caspase-3 (show CASP3 ELISA Kits) activation
Identification of the third vertebrate homologue of Smac/DIABLO.
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
Direct IAP-binding protein with low pI
, diablo homolog, mitochondrial
, second mitochondria-derived activator of caspase
, direct IAP binding protein with low PI
, direct IAP-binding protein with low pI
, diablo homolog
, mitochondrial diablo-like protein
, mitochondrial diablo
, second mitochondrial derived activator of caspases
, Second mitochondria-derived activator of caspase