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Browse our FASL Proteins (FASL)

Full name:
Fas Ligand (TNF Superfamily, Member 6) Proteins (FASL)
On are 50 Fas Ligand (TNF Superfamily, Member 6) (FASL) Proteins from 14 different suppliers available. Additionally we are shipping FASL Antibodies (397) and FASL Kits (110) and many more products for this protein. A total of 570 FASL products are currently listed.
ALPS1B, Apt1Lg1, APTL, CD95-L, CD95L, CD178, FAS, Fas-L, Fasl, Faslg, gld, TNFRSF6, Tnfsf6, zgc:162027
list all proteins Gene Name GeneID UniProt
FASL 356 P48023
FASL 14103 P41047
FASL 25385 P36940

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FASL Proteins (FASL) by Origin

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Top referenced FASL Proteins

  1. Human FASL Protein expressed in CHO Cells - ABIN2666946 : Bodmer, Schneider, Tschopp: The molecular architecture of the TNF superfamily. in Trends in biochemical sciences 2002 (PubMed)
    Show all 7 references for ABIN2666946

  2. Human FASL Protein expressed in Escherichia coli (E. coli) - ABIN1098737 : Kirkin, Cahuzac, Guardiola-Serrano, Huault, Lückerath, Friedmann, Novac, Wels, Martoglio, Hueber, Zörnig: The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. in Cell death and differentiation 2007 (PubMed)
    Show all 2 references for ABIN1098737

  3. Human FASL Protein expressed in Yeast - ABIN2002423 : Hane, Lowin, Peitsch, Becker, Tschopp: Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain. in FEBS letters 1995 (PubMed)

More Proteins for FASL Interaction Partners

Horse (Equine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. demonstration of presence of FAS and FASL in the equine corpus luteum throughout the luteal phase

Human Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. suppression of EP1 (show PTGER1 Proteins) prevented RAMA-induced FasL suppression in CLT85 cells at both the mRNA and protein levels

  2. In sprint-trained male athletes, FasL, miR (show MLXIP Proteins)-21, and miR (show MLXIP Proteins)-146a were measured cross-sectionally (n = 67, 18-90 yrs (show Yars Proteins)) and serum FasL, miR (show MLXIP Proteins)-21, and miR (show MLXIP Proteins)-146a and their aging-related associations with physical performance were assessed over a 10-year follow-up (n = 49, 50-90 yrs (show Yars Proteins)).

  3. In women with endometriosis, immunostaining for Fas-Ligand in the eutopic endometrium was stronger in the epithelial cells of secretory phase, while the epithelial cells of endometriotic lesions showed a significantly stronger staining for Fas-Ligand independently from the menstrual phase

  4. Genetic polymorphisms in the death pathway genes Fas (show FAS Proteins) and FasL were not associated with risk of developing esophageal carcinoma in a north Chinese population.

  5. Polymorphisms of FAS (show FAS Proteins) (-670 G/A), FASL (-844 T/C) and their circulating levels play an important role in the pathology of coronary artery disease.

  6. The study identified Fas ligand (FASLG) as the target of let-7e-5p, and FASLG knockdown increased the migration and tube formation of endothelial progenitor cell.

  7. Advanced glycation end-product induces apoptosis in human retinal cells via promoting mitochondrial dysfunction and activating the Fas (show FAS Proteins)-FasL signaling.

  8. Fas (show FAS Proteins)/FasL system and downstream activation of caspases are important mediators of apoptosis and may be involved in the pathogenesis of pulmonary edema in severe P. falciparum malaria patients.

  9. Case Reports: patients with autosomal recessive inheritance of ALPS-FASLG have a severe phenotype and a partial defect in activation-induced cell death in T- and B-cell lines.

  10. These results suggested that FAS (show FAS Proteins)/FASL polymorphisms might significantly modify SPM (show NPC1 Proteins) risk among patients with SCCHN in a tumor site-specific manner.

Mouse (Murine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. The inhibition/facilitation of miR (show MLXIP Proteins)-98 expression in myocardial cells can modulate apoptosis. miR (show MLXIP Proteins)-98 was downregulated in the peripheral blood of myocarditis patients. It may interact with the FAS (show FAS Proteins)/FASL gene pair to further modulate cell apoptosis.

  2. Our findings revealed a significant association of Fas (show FAS Proteins) -670 GG, FasL -844 TC, and CC genotypes with increased risk of Chronic myeloid leukemia (show BCL11A Proteins)

  3. Different expression of FasL in placentas from Idiopathic intrauterine growth retardation (IUGR) and IUGR + Pre-eclampsia suggests that FasL probably has a different role in the etiology of these two syndromes.

  4. Fas (show FAS Proteins)/FasL Complex Promotes Proliferation and Migration of Brain Endothelial Cells Via FADD (show FADD Proteins)-FLIP-TRAF (show TRAF1 Proteins)-NF-kappaB (show NFKB1 Proteins) Pathway

  5. Increased FasL expression is thought to be a basis for the immune evasion in non-small cell lung carcinomas.

  6. The MWM showed that compared with FAS (show FAS Proteins)- and FASL-knockout mice treated with sevoflurane, sevoflurane treatment of wild-type mice significantly prolonged the escape latency and reduced platform crossing times.

  7. The present study confirmed that both Fas (show FAS Proteins)/FasL signaling and SOCS1 (show SOCS1 Proteins) promoted the high glucose induced mitochondrial dysfunction and apoptosis; results implies the key regulatory role of Fas (show FAS Proteins) signaling and SOCS (show CISH Proteins) in diabetic retinopathy

  8. Meta-analysis: FASL -844 T/C polymorphism is associated with susceptibility to systemic lupus erythematosus.

  9. Activation of TIM1 (show ARHGEF5 Proteins) by exposing the cells to TIM4 (show TIMD4 Proteins) significantly increased the frequency of apoptotic colon cancer cells. The expression of FasL was increased in the cancer cells after treating by TIM4 (show TIMD4 Proteins).

  10. FAS (show FAS Proteins) or FASL gene knockout might attenuate increase of caspase-3 (show CASP3 Proteins) caused by isoflurane.

Pig (Porcine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. Data suggest forkhead box protein O1 (FoxO1 (show FOXO1 Proteins)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL expression during follicular atresia.

  2. FasL was not detected on fetal pig pancreatic cells but could be induced on both beta and non-beta cells when the cells were treated with IL1beta (show IL1B Proteins).

  3. The expression of FAS (show FAS Proteins) and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported

  4. the result indicates that the expression of FasL by chondrocytes is capable of inducing apoptosis of activated T cells

Rhesus Monkey Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. The present results may provide some insights to understand the role of Fas (show FAS Proteins)/FasL in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.

Cow (Bovine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. It was concluded that the Fas (show FAS Proteins)-FasL signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (show TDO2 Proteins) cell lymphoma/leukemia-2 associated X upregulation.

  2. activation of the Fas (show FAS Proteins) pathway and presence of FSH (show BRD2 Proteins) during in vitro maturation increased the incidence of apoptosis in cumulus cells

FASL Protein Profile

Protein Summary

The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).

Alternative names and synonyms associated with FASL

  • Fas ligand (TNF superfamily, member 6) (faslg)
  • Fas (TNF receptor superfamily, member 6) (FAS)
  • Fas ligand (TNF superfamily, member 6) (FASLG)
  • Fas (TNF receptor superfamily, member 6) (fas)
  • fas ligand (LOC100344073)
  • Fas ligand (TNF superfamily, member 6) (Fasl)
  • Fas ligand (TNF superfamily, member 6) (Faslg)
  • ALPS1B protein
  • Apt1Lg1 protein
  • APTL protein
  • CD95-L protein
  • CD95L protein
  • CD178 protein
  • FAS protein
  • Fas-L protein
  • Fasl protein
  • Faslg protein
  • gld protein
  • TNFRSF6 protein
  • Tnfsf6 protein
  • zgc:162027 protein

Protein level used designations for FASL

fas antigen , fas ligand receptor soluble form , tumor necrosis factor receptor superfamily member 6 , Fas ligand (TNF superfamily, member 6) , Fas (TNF receptor superfamily, member 6) , Fas antigen , tumor necrosis factor receptor superfamily, member 6 , tumor necrosis factor ligand superfamily member 6 , apoptosis (APO-1) antigen ligand 1 , CD95 ligand , apoptosis antigen ligand , fas antigen ligand , tumor necrosis factor (ligand) superfamily, member 6 , Fas antigen ligand , generalized lymphoproliferative disease , Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand) , CD95L protein , Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand) , Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand) , FAS antigen CD95 , APO-1 ligand , TNF superfamily, member 6

100192357 Xenopus laevis
395274 Gallus gallus
442968 Canis lupus familiaris
469584 Pan troglodytes
486469 Canis lupus familiaris
493881 Felis catus
735295 Danio rerio
738331 Pan troglodytes
768248 Danio rerio
100071639 Equus caballus
100124789 Xenopus (Silurana) tropicalis
100144426 Ovis aries
429064 Gallus gallus
100344073 Oryctolagus cuniculus
356 Homo sapiens
14103 Mus musculus
25385 Rattus norvegicus
493945 Felis catus
396726 Sus scrofa
574159 Macaca mulatta
407111 Bos taurus
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