Browse our FASL Proteins (FASL)

Full name:
Fas Ligand (TNF Superfamily, Member 6) Proteins (FASL)
On are 57 Fas Ligand (TNF Superfamily, Member 6) (FASL) Proteins from 13 different suppliers available. Additionally we are shipping FASL Antibodies (536) and FASL Kits (122) and many more products for this protein. A total of 728 FASL products are currently listed.
ALPS1B, Apt1Lg1, APTL, CD95-L, CD95L, CD178, FAS, Fas-L, Fasl, Faslg, gld, TNFRSF6, Tnfsf6, zgc:162027
list all proteins Gene Name GeneID UniProt
FASL 356 P48023
FASL 14103 P41047
FASL 25385 P36940

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FASL Proteins (FASL) by Origin

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Top referenced FASL Proteins

  1. Human FASL Protein expressed in CHO Cells - ABIN2666946 : Bodmer, Schneider, Tschopp: The molecular architecture of the TNF superfamily. in Trends in biochemical sciences 2002 (PubMed)
    Show all 7 references for 2666946

  2. Human FASL Protein expressed in Escherichia coli (E. coli) - ABIN1098737 : Kirkin, Cahuzac, Guardiola-Serrano, Huault, Lückerath, Friedmann, Novac, Wels, Martoglio, Hueber, Zörnig: The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. in Cell death and differentiation 2007 (PubMed)
    Show all 2 references for 1098737

  3. Human FASL Protein expressed in Yeast - ABIN2002423 : Hane, Lowin, Peitsch, Becker, Tschopp: Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain. in FEBS letters 1995 (PubMed)

More Proteins for FASL Interaction Partners

Horse (Equine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. demonstration of presence of FAS and FASL in the equine corpus luteum throughout the luteal phase

Human Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. Results show that the FasL:Fas complex shares structural features with the FasL:DcR3 assembly and the glycosylation contributes to the activity of soluble FasL

  2. The dysregulation of ADAM10 (show ADAM10 Proteins), Fas (show FAS Proteins) and FasL could be useful indicators of the progression and severity of OSCC.

  3. FASLG c.-844TC genotype may be protective against familial mediterranean fever (show MEFV Proteins) in the Turkish population.

  4. The rs763110 TT genotype significantly increased the risk of cervical cancer compared with the CC/CT genotype. Patients carrying this genotype presented a lower cancerous FASL expression than that of the CC/CT genotypes. OCT1 (show POU2F1 Proteins) was recruited to the FASL promoter region and regulated the FASL gene transcription by interacting with C/EBPbeta (show CEBPB Proteins).

  5. Inhibition of miR-149-5p can induce apoptosis in THP-1 cells. These inductive effects might be via targeting FASLG and activating FADD and caspases.

  6. FasL gene polymorphism is associated with Hashimoto's thyroiditis.

  7. There is a positive correlation of the serum level of sFasL ( Fas (show FAS Proteins)/FasL axis )with uptake index of parotid gland in our expectation. In addition, liver injury involvement in SS patients showed decreased level of sFasL. Furthermore, we here also observed that the protective cytokine IL-10 (show IL10 Proteins) expression was positively correlated with sFasL expression

  8. The Fas (show FAS Proteins)-1377G > A polymorphism is associated with a higher risk of pre-eclampsia.

  9. suppression of EP1 (show PTGER1 Proteins) prevented RAMA-induced FasL suppression in CLT85 cells at both the mRNA and protein levels

  10. In sprint-trained male athletes, FasL, miR (show MLXIP Proteins)-21, and miR (show MLXIP Proteins)-146a were measured cross-sectionally (n = 67, 18-90 yrs (show Yars Proteins)) and serum FasL, miR (show MLXIP Proteins)-21, and miR (show MLXIP Proteins)-146a and their aging-related associations with physical performance were assessed over a 10-year follow-up (n = 49, 50-90 yrs (show Yars Proteins)).

Mouse (Murine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. FasL expression in splenic CD5 (show CD5 Proteins)(+)CD1d (show CD1D Proteins)(hi) B cells was decreased compared to the control group after TLR4 (show TLR4 Proteins) ligation.

  2. The interaction of Fas receptor (show FAS Proteins) with FasL leads to an activation of the Tag7 (show PGLYRP1 Proteins)-Hsp70 (show HSP70 Proteins) complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA (show MICA Proteins) stress ligand with the NKG2D (show KLRK1 Proteins) receptor is necessary for the release of this cytotoxic complex

  3. this study shows that one-time intraocular adeno (show ADORA2A Proteins)-associated virus-mediated gene delivery of soluble FasL provides complete and sustained neuroprotection in the models of glaucoma

  4. Study found that propofol anesthesia activates Fas (show FAS Proteins)/FasL-mediated extrinsic and Bcl-2 (show BCL2 Proteins)-dependent intrinsic apoptotic pathways, resulting in caspase-8 (show CASP8 Proteins) and caspase-9 (show CASP9 Proteins) activations, respectively, and established upregulation of caspase-1 (show CASP1 Proteins) and IL-1beta (show IL1B Proteins) cytokine transcriptions as well as subsequent activation of microglia. Behavioral data revealed that hyperactivity persists through adolescence and young adulthood.

  5. this study shows that neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells restricts autoantibody production by B cells during inflammasome-driven inflammation

  6. Expression of FasL on the surface of peripheral B-1 cells increased in filarial patients and positively correlated with peripheral apoptotic T-helper cells indicating FasL-expressing B-1 cells may be one of the important mediators of Th-cell apoptosis and immune anergy during filarial pathology.

  7. the activation of ERK5 (show MAPK7 Proteins)-AKT (show AKT1 Proteins)-FoxO3a (show FOXO3 Proteins) signaling pathways by fluid shear stress resulted in a decreased expression of FasL and Bim (show BCL2L11 Proteins) and an inhibition of caspase-3 (show CASP3 Proteins) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.

  8. these data show for the first time LRH-1 (show NR5A2 Proteins) expression in T cells, its role in FASLG transcription and the potential of pharmacological inhibition of LRH-1 (show NR5A2 Proteins) in the treatment of FasL-mediated immunopathologies

  9. CD95L has a proliferation-stimulating role during normal turnover of the small intestine, but has a marginal effect on overall intestinal homeostasis.

  10. Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14.

Pig (Porcine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. Data suggest forkhead box protein O1 (FoxO1 (show FOXO1 Proteins)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL expression during follicular atresia.

  2. FasL was not detected on fetal pig pancreatic cells but could be induced on both beta and non-beta cells when the cells were treated with IL1beta (show IL1B Proteins).

  3. The expression of FAS (show FAS Proteins) and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported

  4. the result indicates that the expression of FasL by chondrocytes is capable of inducing apoptosis of activated T cells

Rhesus Monkey Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. The present results may provide some insights to understand the role of Fas (show FAS Proteins)/FasL in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.

Cow (Bovine) Fas Ligand (TNF Superfamily, Member 6) (FASL) interaction partners

  1. It was concluded that the Fas (show FAS Proteins)-FasL signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (show TDO2 Proteins) cell lymphoma/leukemia-2 associated X upregulation.

  2. activation of the Fas (show FAS Proteins) pathway and presence of FSH (show BRD2 Proteins) during in vitro maturation increased the incidence of apoptosis in cumulus cells

FASL Protein Profile

Protein Summary

The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).

Alternative names and synonyms associated with FASL

  • Fas ligand (TNF superfamily, member 6) (faslg)
  • Fas (TNF receptor superfamily, member 6) (FAS)
  • Fas ligand (TNF superfamily, member 6) (FASLG)
  • Fas (TNF receptor superfamily, member 6) (fas)
  • fas ligand (LOC100344073)
  • Fas ligand (TNF superfamily, member 6) (Fasl)
  • Fas ligand (TNF superfamily, member 6) (Faslg)
  • ALPS1B protein
  • Apt1Lg1 protein
  • APTL protein
  • CD95-L protein
  • CD95L protein
  • CD178 protein
  • FAS protein
  • Fas-L protein
  • Fasl protein
  • Faslg protein
  • gld protein
  • TNFRSF6 protein
  • Tnfsf6 protein
  • zgc:162027 protein

Protein level used designations for FASL

fas antigen , fas ligand receptor soluble form , tumor necrosis factor receptor superfamily member 6 , Fas ligand (TNF superfamily, member 6) , Fas (TNF receptor superfamily, member 6) , Fas antigen , tumor necrosis factor receptor superfamily, member 6 , tumor necrosis factor ligand superfamily member 6 , apoptosis (APO-1) antigen ligand 1 , CD95 ligand , apoptosis antigen ligand , fas antigen ligand , tumor necrosis factor (ligand) superfamily, member 6 , Fas antigen ligand , generalized lymphoproliferative disease , Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand) , CD95L protein , Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand) , Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand) , FAS antigen CD95 , APO-1 ligand , TNF superfamily, member 6

100192357 Xenopus laevis
395274 Gallus gallus
442968 Canis lupus familiaris
469584 Pan troglodytes
486469 Canis lupus familiaris
493881 Felis catus
735295 Danio rerio
738331 Pan troglodytes
768248 Danio rerio
100071639 Equus caballus
100124789 Xenopus (Silurana) tropicalis
100144426 Ovis aries
429064 Gallus gallus
100344073 Oryctolagus cuniculus
356 Homo sapiens
14103 Mus musculus
25385 Rattus norvegicus
493945 Felis catus
396726 Sus scrofa
574159 Macaca mulatta
407111 Bos taurus
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