Browse our PARP1 Proteins (PARP1)

Full name:
Poly (ADP-Ribose) Polymerase 1 Proteins (PARP1)
On www.antibodies-online.com are 30 Poly (ADP-Ribose) Polymerase 1 (PARP1) Proteins from 14 different suppliers available. Additionally we are shipping PARP1 Antibodies (418) and PARP1 Kits (36) and many more products for this protein. A total of 512 PARP1 products are currently listed.
Synonyms:
5830444G22Rik, Adprp, Adprt, ADPRT 1, Adprt1, AI893648, ARTD1, BEST:LD21673, C80510, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, dPARP, LD21673.3prime, padprt-1, parp, parp-1, PARP1, ppol, sPARP-1
list all proteins Gene Name GeneID UniProt
PARP1 142 P09874
Rat PARP1 PARP1 25591 P27008
PARP1 11545  

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PARP1 Proteins (PARP1) by Origin

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Top referenced PARP1 Proteins

  1. Human PARP1 Protein expressed in Baculovirus - ABIN1741730 : Woodhouse, Dianov: Poly ADP-ribose polymerase-1: an international molecule of mystery. in DNA repair 2008 (PubMed)
    Show all 11 references for 1741730

  2. Human PARP1 Protein expressed in Baculovirus - ABIN1741729 : Lamarre, Talbot, de Murcia, Laplante, Leduc, Mazen, Poirier: Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. in Biochimica et biophysica acta 1988 (PubMed)
    Show all 9 references for 1741729

  3. Mouse (Murine) PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2008275 : Ariumi, Masutani, Copeland, Mimori, Sugimura, Shimotohno, Ueda, Hatanaka, Noda: Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. in Oncogene 1999 (PubMed)
    Show all 3 references for 2008275

  4. Human PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003759 : Ahel, Ahel, Matsusaka, Clark, Pines, Boulton, West: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. in Nature 2008 (PubMed)
    Show all 3 references for 2003759

  5. Human PARP1 Protein expressed in Escherichia coli (E. coli) - ABIN666940 : Li, Oh, Lau: The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. in Molecular and cellular endocrinology 2006 (PubMed)
    Show all 2 references for 666940

More Proteins for PARP1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.

  2. A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (show PARK2 Proteins) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (show PARK2 Proteins) mutants.

  3. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (show H2AFV Proteins) in a nucleosome positioned in promoter regions of PARP-1-dependent genes

  4. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis

  5. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.

  6. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.

  7. PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).

  8. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.

  9. PARP-e autoregulates Parp transcription

  10. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff

Human Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. Elevated PARP expression correlated with worse prognosis in early stage breast cancer. [meta-analysis]

  2. study demonstrates that the individual and combined expression patterns of the DDR (show DDR1 Proteins) molecules PARP1, gammaH2AX (show H2AFX Proteins), BRCA1, and BRCA2 (show BRCA2 Proteins) could be predictive of the prognosis of STS (show STS Proteins) patients and suggests that controlling the activity of these DDR (show DDR1 Proteins) molecules could be employed in new therapeutic stratagems for the treatment of STS (show STS Proteins)

  3. PARP1/2 inhibitor simmiparib causes growth inhibition in cancer cell- or tissue-derived xenografts in nude mice.

  4. either PARP1 or PARP2 (show PARP2 Proteins) are sufficient for near-normal XRCC1 (show XRCC1 Proteins) recruitment at oxidative single-strand breaks

  5. HPF1/C4orf27 Is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity in the DNA damage response.

  6. Further analysis suggested that H2AX (show H2AFX Proteins), a PARP-1 protein interaction partner, was coordinated with PARP-1 in hepatocellular carcinoma tumorigenesis. Overall, some new characteristics of PARP-1 expression were noted in the Zhuang population. PARP-1 is a novel promising diagnostic marker for hepatocellular carcinoma in the Southern Chinese Zhuang population

  7. Knockdown of endogenous Mcl-1 (show MCL1 Proteins) by RNA interference significantly accelerated the repair of DNA lesions in glycochenodeoxycholate-treated cells. However, unlike XRCC1 (show XRCC1 Proteins), poly(ADP-ribose) polymerase was induced following Mcl-1 (show MCL1 Proteins) knockdown. Conversely, poly(ADP-ribose) polymerase suppression was observed following glycochenodeoxycholate treatment of cells overexpressing Mcl-1 (show MCL1 Proteins)

  8. Binding of PARP1 at the BZLF1 lytic switch promoter restricts Epstein Barr Virus reactivation.

  9. The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 (show RECQL Proteins) DNA helicase and ERCC1 (show ERCC1 Proteins)-XPF endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase and RPA (show RPA1 Proteins).

  10. Data show that in the presence of poly-(ADP-ribose)-polymerase1 (PARP1) inhibitor, ten-fold lower concentration of cisplatin (cDDP) can be used to induce similar cytotoxic effects.

Cow (Bovine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected

  2. ADPRT Val762Ala and APE1 (show APEX1 Proteins) Asp148Glu polymorphisms are not associated with increased breast cancer risk

  3. analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites

  4. FGF2 (show FGF2 Proteins) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (show MAPK1 Proteins))-dependent pathway

Mouse (Murine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. Delayed healing in ischemic and diabetic wounds is caused by PARP hyperactivity, and PARP inhibition significantly enhanced ischemic and diabetic wound healing by promoting angiogenesis.

  2. The findings highlight specific non-overlapping functions of PARP1 and PARP2 (show PARP2 Proteins) at H2AX (show H2AFX Proteins)-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 in nonhomologous end-joining-deficient cells.

  3. data establish the importance of XRCC1 (show XRCC1 Proteins) protein complexes for normal neurological function and identify PARP1 as a therapeutic target in DNA strand break repair-defective disease

  4. this study shows that PARP-1 inhibition plays role in puerarin-mediated protection from liver fibrosis

  5. might be involved in streptomycin ototoxicity by regulating AIF (show AIFM1 Proteins) translocation in cochlear hair cells

  6. Nonionizing radiofrequency exposure is capable of inducing PARP-1.

  7. our data suggest that Parp1 is involved in the plastic remodeling of chromatin structure after NT by supporting DNA repair and specific histone code modifications.

  8. ARTD1 controls osteoclast development and bone remodelling via its enzymatic activity by modulating the epigenetic marks surrounding the IL-1beta (show IL1B Proteins) promoter and expression of IL-1beta (show IL1B Proteins) and subsequently also Nfatc1 (show NFATC1 Proteins)/A.

  9. the role of PARP-1 in age-dependent changes in endothelial cell function and its underlying mechanism

  10. Both depletion of PARP-1 and inhibition of PARP-1 activity augmented LXR (show NR1H3 Proteins) ligand-induced ABCA1 (show ABCA1 Proteins) expression in the RAW 264.7 macrophage line and primary bone marrow-derived macrophages but did not affect LXR (show NR1H3 Proteins)-dependent expression of other target genes, ABCG1 (show ABCG1 Proteins) and SREBP-1c (show SREBF1 Proteins).

PARP1 Protein Profile

Protein Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Alternative names and synonyms associated with PARP1

  • Poly-(ADP-ribose) polymerase (Parp)
  • poly (ADP-ribose) polymerase 1 (PARP1)
  • poly (ADP-ribose) polymerase 1 (Parp1)
  • poly (ADP-ribose) polymerase 1 (parp1)
  • poly (ADP-ribose) polymerase family, member 1 (Parp1)
  • poly ADP-ribose polymerase (Parp)
  • 5830444G22Rik protein
  • Adprp protein
  • Adprt protein
  • ADPRT 1 protein
  • Adprt1 protein
  • AI893648 protein
  • ARTD1 protein
  • BEST:LD21673 protein
  • C80510 protein
  • CG17685 protein
  • CG17696 protein
  • CG17718 protein
  • CG40411 protein
  • D.PARP protein
  • Dm.pARTa protein
  • Dmel\\CG40411 protein
  • dPARP protein
  • LD21673.3prime protein
  • padprt-1 protein
  • parp protein
  • parp-1 protein
  • PARP1 protein
  • ppol protein
  • sPARP-1 protein

Protein level used designations for PARP1

CG40411-PB , CG40411-PC , Parp-PB , Parp-PC , Poly(ADP ribose) polymerase 1 , Poly(ADP)-Ribose polymerase , Poly(ADP-)Ribose polymerase , Poly(ADP-ribose) polymerase , Poly(ADP-ribose) polymerase 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) , ADP-ribosyltransferase NAD(+) , ADP-ribosyltransferase diphtheria toxin-like 1 , NAD(+) ADP-ribosyltransferase 1 , poly (ADP-ribose) polymerase family, member 1 , poly [ADP-ribose] polymerase 1 , poly(ADP-ribose) polymerase , poly(ADP-ribose) synthetase , poly(ADP-ribosyl)transferase , poly[ADP-ribose] synthase 1 , ADP-ribosyltransferase (NAD+ , ADP-ribosyltransferase 1 , ADPRT 1 , poly (ADP-ribose) polymerase) , poly(ADP-ribose) polymerase PARP-1 , poly[ADP-ribose] synthetase 1 , ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase) , PARP-1 , ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1 , msPARP , Poly[ADP-ribose] synthase 1

GENE ID SPECIES
3355109 Drosophila melanogaster
142 Homo sapiens
25591 Rattus norvegicus
286764 Bos taurus
397928 Xenopus laevis
396199 Gallus gallus
490385 Canis lupus familiaris
11545 Mus musculus
100689463 Cricetulus griseus
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