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Browse our PARP1 Proteins (PARP1)

Full name:
Poly (ADP-Ribose) Polymerase 1 Proteins (PARP1)
On www.antibodies-online.com are 26 Poly (ADP-Ribose) Polymerase 1 (PARP1) Proteins from 15 different suppliers available. Additionally we are shipping PARP1 Antibodies (422) and PARP1 Kits (25) and many more products for this protein. A total of 501 PARP1 products are currently listed.
Synonyms:
5830444G22Rik, Adprp, Adprt, ADPRT 1, Adprt1, AI893648, ARTD1, BEST:LD21673, C80510, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, dPARP, LD21673.3prime, padprt-1, parp, parp-1, PARP1, ppol, sPARP-1
list all proteins Gene Name GeneID UniProt
PARP1 142 P09874
Rat PARP1 PARP1 25591 P27008
PARP1 11545  

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PARP1 Proteins (PARP1) by Origin

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Top referenced PARP1 Proteins

  1. Human PARP1 Protein expressed in Baculovirus - ABIN1741730 : Woodhouse, Dianov: Poly ADP-ribose polymerase-1: an international molecule of mystery. in DNA repair 2008 (PubMed)
    Show all 11 references for ABIN1741730

  2. Human PARP1 Protein expressed in Baculovirus - ABIN1741729 : Lamarre, Talbot, de Murcia, Laplante, Leduc, Mazen, Poirier: Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. in Biochimica et biophysica acta 1988 (PubMed)
    Show all 9 references for ABIN1741729

  3. Mouse (Murine) PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2008275 : Ariumi, Masutani, Copeland, Mimori, Sugimura, Shimotohno, Ueda, Hatanaka, Noda: Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. in Oncogene 1999 (PubMed)
    Show all 3 references for ABIN2008275

  4. Human PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003759 : Ahel, Ahel, Matsusaka, Clark, Pines, Boulton, West: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. in Nature 2008 (PubMed)
    Show all 3 references for ABIN2003759

  5. Human PARP1 Protein expressed in Escherichia coli (E. coli) - ABIN666940 : Li, Oh, Lau: The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. in Molecular and cellular endocrinology 2006 (PubMed)
    Show all 2 references for ABIN666940

More Proteins for PARP1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (show PARK2 Proteins) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (show PARK2 Proteins) mutants.

  2. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (show H2AFV Proteins) in a nucleosome positioned in promoter regions of PARP-1-dependent genes

  3. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis

  4. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.

  5. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.

  6. PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).

  7. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.

  8. PARP-e autoregulates Parp transcription

  9. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff

  10. PARP1 is required for protein targeting to Cajal body.

Human Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. Curcumin induces apoptosis in leukemia cells via PARP-1 mediated caspase-3 (show CASP3 Proteins) dependent pathway.

  2. the effect of PARP1 Val762Ala polymorphism in treatment response in cervical cancer patients

  3. Overexpression of miR (show MLXIP Proteins)-335 decreased the expression of PARP-1 mRNA and protein, and NF-kappaB (show NFKB1 Proteins) protein levels were correspondingly downregulated, thus regulating the chemo-radiosensitivity of small cell lung cancer cells.

  4. Participants were genotyped for a functional non-synonymous single-nucleotide polymorphism (2456T/C; rs1136410) that results in the conversion of a conserved valine residue to alanine (762Val/Ala) in the amino-acid sequence of PARP-1

  5. This review assesses current developments in PARP-1 biology and activation signals for PARP-1, other than conventional DNA damage activation. [review]

  6. High expression of PARP1 is significantly associated with chordoma invasion and recurrence. PARP1 may become a potential biomarker for chordoma in predicting its recurrence and patients' prognosis.

  7. During live-cell imaging, 53BP1 (show TP53BP1 Proteins)-GFP focus formation was observed within 10 minutes after UVC irradiation. Most 53BP1 (show TP53BP1 Proteins) foci resolved by 100 minutes. To block UVC-induced double-strand break repair in cancer cells, poly(ADP-ribose) polymerase (PARP) was targeted with ABT-888 (veliparib). PARP inhibition markedly enhanced UVC-irradiation-induced persistence of 53BP1 (show TP53BP1 Proteins)-foci

  8. In a population of Sicilian patients with Parkinson's disease, the PARP-1 - 410 C/T genotype was not associated with protection from Parkinson's disease.

  9. Collectively, our results suggest that PARP1 imaging with PARPi-FL can enhance the detection of oral cancer, serve as a screening tool and help to guide surgical resections.

  10. This meta-analysis suggests that PARP1 rs1136410 T>C may play a significant role in the protection against the development of brain tumors and glioma.

Cow (Bovine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected

  2. ADPRT Val762Ala and APE1 (show APEX1 Proteins) Asp148Glu polymorphisms are not associated with increased breast cancer risk

  3. analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites

  4. FGF2 (show FGF2 Proteins) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (show MAPK1 Proteins))-dependent pathway

Mouse (Murine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. ARTD1 controls osteoclast development and bone remodelling via its enzymatic activity by modulating the epigenetic marks surrounding the IL-1beta (show IL1B Proteins) promoter and expression of IL-1beta (show IL1B Proteins) and subsequently also Nfatc1 (show NFATC1 Proteins)/A.

  2. the role of PARP-1 in age-dependent changes in endothelial cell function and its underlying mechanism

  3. Both depletion of PARP-1 and inhibition of PARP-1 activity augmented LXR (show NR1H3 Proteins) ligand-induced ABCA1 (show ABCA1 Proteins) expression in the RAW 264.7 macrophage line and primary bone marrow-derived macrophages but did not affect LXR (show NR1H3 Proteins)-dependent expression of other target genes, ABCG1 (show ABCG1 Proteins) and SREBP-1c (show SREBF1 Proteins).

  4. unless it is degraded, ARTD1 represses OC development through transcriptional regulation.

  5. The protective effects conferred by Parp1 deletion were lost in Rag2 (show RAG2 Proteins)(-/-) x Parp1(-/-) mice, highlighting the role of the adaptive immune system for full protection.

  6. Data show reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 (show PARP2 Proteins) knockout mice.

  7. By enhancing PARP1 activity, ULK1 (show ULK1 Proteins) contributes to ATP depletion and death of H2O2-treated cells.

  8. PARP-1 deficiency significantly increased the chromatin binding affinity of MeCP2 (show MECP2 Proteins) in vivo.

  9. these results identify CHD1L (show CHD1L Proteins) as a key chromatin remodeler involved in PARP1/PARylation-regulated early-stage reprogramming and pluripotency in stem cells.

  10. PARP-1 activation is required for the consolidation, reconsolidation, and extinction of contextual fear memory

PARP1 Protein Profile

Protein Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Alternative names and synonyms associated with PARP1

  • Poly-(ADP-ribose) polymerase (Parp)
  • poly (ADP-ribose) polymerase 1 (PARP1)
  • poly (ADP-ribose) polymerase 1 (Parp1)
  • poly (ADP-ribose) polymerase 1 (parp1)
  • poly (ADP-ribose) polymerase family, member 1 (Parp1)
  • poly ADP-ribose polymerase (Parp)
  • 5830444G22Rik protein
  • Adprp protein
  • Adprt protein
  • ADPRT 1 protein
  • Adprt1 protein
  • AI893648 protein
  • ARTD1 protein
  • BEST:LD21673 protein
  • C80510 protein
  • CG17685 protein
  • CG17696 protein
  • CG17718 protein
  • CG40411 protein
  • D.PARP protein
  • Dm.pARTa protein
  • Dmel\\CG40411 protein
  • dPARP protein
  • LD21673.3prime protein
  • padprt-1 protein
  • parp protein
  • parp-1 protein
  • PARP1 protein
  • ppol protein
  • sPARP-1 protein

Protein level used designations for PARP1

CG40411-PB , CG40411-PC , Parp-PB , Parp-PC , Poly(ADP ribose) polymerase 1 , Poly(ADP)-Ribose polymerase , Poly(ADP-)Ribose polymerase , Poly(ADP-ribose) polymerase , Poly(ADP-ribose) polymerase 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) , ADP-ribosyltransferase NAD(+) , ADP-ribosyltransferase diphtheria toxin-like 1 , NAD(+) ADP-ribosyltransferase 1 , poly (ADP-ribose) polymerase family, member 1 , poly [ADP-ribose] polymerase 1 , poly(ADP-ribose) polymerase , poly(ADP-ribose) synthetase , poly(ADP-ribosyl)transferase , poly[ADP-ribose] synthase 1 , ADP-ribosyltransferase (NAD+ , ADP-ribosyltransferase 1 , ADPRT 1 , poly (ADP-ribose) polymerase) , poly(ADP-ribose) polymerase PARP-1 , poly[ADP-ribose] synthetase 1 , ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase) , PARP-1 , ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1 , msPARP , Poly[ADP-ribose] synthase 1

GENE ID SPECIES
3355109 Drosophila melanogaster
142 Homo sapiens
25591 Rattus norvegicus
286764 Bos taurus
397928 Xenopus laevis
396199 Gallus gallus
490385 Canis lupus familiaris
11545 Mus musculus
100689463 Cricetulus griseus
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