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Browse our PARP1 Proteins (PARP1)

Full name:
Poly (ADP-Ribose) Polymerase 1 Proteins (PARP1)
On are 25 Poly (ADP-Ribose) Polymerase 1 (PARP1) Proteins from 15 different suppliers available. Additionally we are shipping PARP1 Antibodies (426) and PARP1 Kits (32) and many more products for this protein. A total of 511 PARP1 products are currently listed.
5830444G22Rik, Adprp, Adprt, ADPRT 1, Adprt1, AI893648, ARTD1, BEST:LD21673, C80510, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, dPARP, LD21673.3prime, padprt-1, parp, parp-1, PARP1, ppol, sPARP-1
list all proteins Gene Name GeneID UniProt
PARP1 142 P09874
Rat PARP1 PARP1 25591 P27008
PARP1 11545  

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PARP1 Proteins (PARP1) by Origin

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Top referenced PARP1 Proteins

  1. Human PARP1 Protein expressed in Baculovirus - ABIN1741730 : Woodhouse, Dianov: Poly ADP-ribose polymerase-1: an international molecule of mystery. in DNA repair 2008 (PubMed)
    Show all 11 references for ABIN1741730

  2. Human PARP1 Protein expressed in Baculovirus - ABIN1741729 : Lamarre, Talbot, de Murcia, Laplante, Leduc, Mazen, Poirier: Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. in Biochimica et biophysica acta 1988 (PubMed)
    Show all 9 references for ABIN1741729

  3. Mouse (Murine) PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2008275 : Ariumi, Masutani, Copeland, Mimori, Sugimura, Shimotohno, Ueda, Hatanaka, Noda: Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. in Oncogene 1999 (PubMed)
    Show all 3 references for ABIN2008275

  4. Human PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003759 : Ahel, Ahel, Matsusaka, Clark, Pines, Boulton, West: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. in Nature 2008 (PubMed)
    Show all 3 references for ABIN2003759

  5. Human PARP1 Protein expressed in Escherichia coli (E. coli) - ABIN666940 : Li, Oh, Lau: The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. in Molecular and cellular endocrinology 2006 (PubMed)
    Show all 2 references for ABIN666940

More Proteins for PARP1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (show H2AFV Proteins) in a nucleosome positioned in promoter regions of PARP-1-dependent genes

  2. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis

  3. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.

  4. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.

  5. PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).

  6. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.

  7. PARP-e autoregulates Parp transcription

  8. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff

  9. PARP1 is required for protein targeting to Cajal body.

Human Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1/2 and tankyrase 1 (show TNKS Proteins)/2 inhibitor which has the advantage of targeting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling addicted tumors.

  2. Non-small cell lung cancer patients with high intra-tumoral PARP1 activity had a poor prognosis.

  3. DNA damage induced necrosis through a PARP1-dependent and p53 (show TP53 Proteins)-independent pathway.

  4. Data indicate that poly(ADP-ribose) polymerase 1 (PARP1) protein is expressed in pediatric high-grade astrocytomas (pHGA) and diffuse intrinsic pontine gliomas (DIPG) patient samples and cell lines.

  5. The initial affinity between the PARP1, PARP2 (show PARP2 Proteins) and the DNA damaged site appears to influence both the size of the Poly(ADP-Ribose) synthesized and the time of residence of PARylated PARP1 and PARP2 (show PARP2 Proteins) on DNA damages.

  6. Our combination strategy could expand the clinical application of PARP-inhibitors to non-BRCA mutated cancers and may target a new group of NSCLC patients who show limited response to current therapies.

  7. PARP-1 has an important role in the progression of acute myeloid leukemia (show BCL11A Proteins) by suppressing the myeloproliferative leukemia virus oncogene (show MPL Proteins)

  8. Data suggest that inhibition of PARP1 (preferential inhibition of PARP1 over PARP2 (show PARP2 Proteins)) arrests cell cycle/cell proliferation and promotes apoptosis of breast tumor cells (including triple negative breast tumor cells).

  9. Activation of the PI3K (show PIK3CA Proteins)/mTOR (show FRAP1 Proteins) Pathway following PARP Inhibition in Small Cell Lung Cancer.

  10. Noncovalent binding of ADP-ribose polymers with TET1 (show TET1 Proteins) catalytic domain decreases TET1 (show TET1 Proteins) hydroxylase activity while the covalent PARylation stimulates TET1 (show TET1 Proteins) enzyme. In addition, TET1 (show TET1 Proteins) activates PARP-1/ARTD1 independently of DNA breaks.

Cow (Bovine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. ADPRT Val762Ala and APE1 (show APEX1 Proteins) Asp148Glu polymorphisms are not associated with increased breast cancer risk

  2. analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites

  3. FGF2 (show FGF2 Proteins) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (show MAPK1 Proteins))-dependent pathway

Mouse (Murine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. Data show reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 (show PARP2 Proteins) knockout mice.

  2. By enhancing PARP1 activity, ULK1 (show ULK1 Proteins) contributes to ATP depletion and death of H2O2-treated cells.

  3. PARP-1 deficiency significantly increased the chromatin binding affinity of MeCP2 (show MECP2 Proteins) in vivo.

  4. these results identify CHD1L (show CHD1L Proteins) as a key chromatin remodeler involved in PARP1/PARylation-regulated early-stage reprogramming and pluripotency in stem cells.

  5. PARP-1 activation is required for the consolidation, reconsolidation, and extinction of contextual fear memory

  6. Suggest role for LRP1 (show LRP1 Proteins)/PARP1 signaling in endothelial cell proliferation and retinal neovascularization induced by hypoxia.

  7. Matrix Metalloproteinase-2 (MMP-2 (show MMP2 Proteins)) Gene Deletion Enhances MMP-9 (show MMP9 Proteins) Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice

  8. PARP-1 inhibition blocks glioma conditioned medium-induced endothelial migration by interfering with ERK (show EPHB2 Proteins) signal-transduction pathway.

  9. The results demonstrate that ARTD1 modulates IL-6 expression by regulating the function of an NF-kappaB enhanceosome complex, which involves MLL1 and does not require ADP-ribosylation.

  10. Results show the stimulatory effect of PARP-1 on APE1 (show APEX1 Proteins)-dependent base excision repair (BER). PARP-1 and APE1 (show APEX1 Proteins) appear to have a functional interaction in BER since PARP-1 can stimulate the strand incision activity of APE1 (show APEX1 Proteins).

PARP1 Protein Profile

Protein Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Alternative names and synonyms associated with PARP1

  • Poly-(ADP-ribose) polymerase (Parp)
  • poly (ADP-ribose) polymerase 1 (PARP1)
  • poly (ADP-ribose) polymerase 1 (Parp1)
  • poly (ADP-ribose) polymerase 1 (parp1)
  • poly (ADP-ribose) polymerase family, member 1 (Parp1)
  • poly ADP-ribose polymerase (Parp)
  • 5830444G22Rik protein
  • Adprp protein
  • Adprt protein
  • ADPRT 1 protein
  • Adprt1 protein
  • AI893648 protein
  • ARTD1 protein
  • BEST:LD21673 protein
  • C80510 protein
  • CG17685 protein
  • CG17696 protein
  • CG17718 protein
  • CG40411 protein
  • D.PARP protein
  • Dm.pARTa protein
  • Dmel\\CG40411 protein
  • dPARP protein
  • LD21673.3prime protein
  • padprt-1 protein
  • parp protein
  • parp-1 protein
  • PARP1 protein
  • ppol protein
  • sPARP-1 protein

Protein level used designations for PARP1

CG40411-PB , CG40411-PC , Parp-PB , Parp-PC , Poly(ADP ribose) polymerase 1 , Poly(ADP)-Ribose polymerase , Poly(ADP-)Ribose polymerase , Poly(ADP-ribose) polymerase , Poly(ADP-ribose) polymerase 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) , ADP-ribosyltransferase NAD(+) , ADP-ribosyltransferase diphtheria toxin-like 1 , NAD(+) ADP-ribosyltransferase 1 , poly (ADP-ribose) polymerase family, member 1 , poly [ADP-ribose] polymerase 1 , poly(ADP-ribose) polymerase , poly(ADP-ribose) synthetase , poly(ADP-ribosyl)transferase , poly[ADP-ribose] synthase 1 , ADP-ribosyltransferase (NAD+ , ADP-ribosyltransferase 1 , ADPRT 1 , poly (ADP-ribose) polymerase) , poly(ADP-ribose) polymerase PARP-1 , poly[ADP-ribose] synthetase 1 , ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase) , PARP-1 , ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1 , msPARP , Poly[ADP-ribose] synthase 1

3355109 Drosophila melanogaster
142 Homo sapiens
25591 Rattus norvegicus
286764 Bos taurus
397928 Xenopus laevis
396199 Gallus gallus
490385 Canis lupus familiaris
11545 Mus musculus
100689463 Cricetulus griseus
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