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Urinary DcR2 (show CCR6 Proteins) could potentially serve as a novel biomarker for tubulointerstitial injury and may reflect senescence of renal proximal tubular cells in diabetic nephropathy.
Results identified epigenetic inactivation of TNFRSF10C (show TNFRSF10C Proteins) and TNFRSF10D in majority of cervical cancer cases.
This study identified TNFRSF10D DNA methylation (show HELLS Proteins) status as an independent prognostic biomarker for relapse-free survival and overall mortality in non-metastatic melanoma patients.
The membrane expression of the TRAIL receptors DR4 (show HLADRB4 Proteins), DR5 (show TNFRSF10B Proteins), DcR1 (show TNFRSF10C Proteins) and DcR2 (show CCR6 Proteins) is greater in normal endometrium than endometrioid adenocarcinoma (EAC (show CYLD Proteins)). The level of the receptors in EAC (show CYLD Proteins) is not dependent on grading and staging and does not predict survival.
the results presented here claim for a relevant impact of aberrant methylation of decoy receptors in melanoma and allow to understand how the silencing of DcR1 (show TNFRSF10C Proteins) and DcR2 (show CCR6 Proteins) is related to melanomagenesis.
transcript levels of UCHL1 (show UCHL1 Proteins), COL1A2 (show COL1A2 Proteins), THBS1 (show THBS1 Proteins) and TNFRSF10D were inversely correlated with promoter methylation
TRAIL receptor-4 expression profiles on T cells might be important in revelation of rheumatoid arthritis pathogenesis.
ANT2 (show SLC25A5 Proteins) shRNA treatment sensitized MCF7, T47 D, and BT474 cells to TRAIL-induced apoptosis by up-regulating the expression of TRAIL death receptors 4 and 5 (DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins)) and down-regulating the TRAIL decoy receptor 2 (DcR2).
these results demonstrated that hypoxia-inducible factor 1alpha played a crucial role in regulating the transcription of DcR2 (show CCR6 Proteins).
TNF-related apoptosis-inducing ligand (TRAIL (show TNFSF10 Proteins)) is not constitutively expressed in the human brain, whereas both apoptosis-mediating and apoptosis-blocking TRAIL receptors are found on neurons, astrocytes, and oligodendrocytes
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
, TNF receptor-related receptor for TRAIL
, TNF-related apoptosis-inducing ligand receptor 4
, TRAIL receptor 4
, TRAIL receptor with a truncated death domain
, decoy receptor 2
, tumor necrosis factor receptor superfamily member 10D