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Browse our TNFRSF25 Proteins (TNFRSF25)

Full name:
Tumor Necrosis Factor Receptor Superfamily, Member 25 Proteins (TNFRSF25)
On are 7 Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25) Proteins from 4 different suppliers available. Additionally we are shipping TNFRSF25 Antibodies (183) and TNFRSF25 Kits (1) and many more products for this protein. A total of 206 TNFRSF25 products are currently listed.
APO-3, DDR3, DR3, LARD, Tnfrsf12, TNFRSF25, TR3, TRAMP, Wsl, WSL-1, WSL-LR
list all proteins Gene Name GeneID UniProt
TNFRSF25 8718 Q93038
Mouse TNFRSF25 TNFRSF25 85030  
Rat TNFRSF25 TNFRSF25 500592  

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TNFRSF25 Proteins (TNFRSF25) by Origin

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Top referenced TNFRSF25 Proteins

  1. Human TNFRSF25 Protein expressed in Human Cells - ABIN2005041 : Kitson, Raven, Jiang, Goeddel, Giles, Pun, Grinham, Brown, Farrow: A death-domain-containing receptor that mediates apoptosis. in Nature 1996 (PubMed)
    Show all 3 references for ABIN2005041

More Proteins for TNFRSF25 Interaction Partners

Human Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25) interaction partners

  1. Higher DR3 levels were associated with early stage chronic lymphocytic leukemia.

  2. DR3 is efficiently activated by soluble TL1A (show TNFSF15 Proteins) trimers.

  3. These data identify new roles for DR3 in regulating OB-dependent bone mineral apposition.

  4. Human memory IL-18Ralpha and DR3 CD4 (show CD4 Proteins)+ T cells may contribute to antigen-independent innate responses at barrier surfaces.

  5. DR3 is expressed by IL-22 (show IL22 Proteins)-producing human group 3 innate lymphoid cells (ILC3s).

  6. These results suggested that TL1A (show TNFSF15 Proteins) could promote Th17 differentiation in rheumatoid arthritis via the activation of RORc (show RORC Proteins), and this effect may be mediated by the binding of TL1A (show TNFSF15 Proteins) with DR3.

  7. Silencing of the DR3 gene affect levels of apoptosis antigen3 ligand in cells.

  8. DR3 (show TNFSF15 Proteins)is expressed in so (show NFKB1 Proteins)me interstitial vascular endothelial cells in human kidney in situ. These EC also respond to TL1A by activating NF-kappaB. Very low levels of DR3 are seen on the cell surface of HUVEC, which do not respond to TL1A.

  9. The changes in frequency of occurrence of spliced variants of DR3/LARD mRNA were directed towards modulation of apoptosis and restraint of antiviral immune response.

  10. Distinctions in occurrence of spectrums of DR3/LARD mRNA at healthy volunteers and colon cancer patients can define a different susceptibility of immunocompetent and tumor cells for apoptosis

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25) interaction partners

  1. These data identify new roles for DR3 in regulating OB-dependent bone mineral apposition.

  2. Data indicate that death receptor 3 (DR3) depletion gives rise to an increased anti-apoptotic potential.

  3. these data identify TL1A (show TNFSF15 Proteins)-DR3 interactions as a novel pathway that promotes Th9 differentiation and pathogenicity. TL1A (show TNFSF15 Proteins) may be a potential therapeutic target in diseases dependent on IL-9 (show IL9 Proteins).

  4. TL1A (show TNFSF15 Proteins) induces NF-kappaB (show NFKB1 Proteins) activation in EC in renal and cardiac tissue from wild type but not DR3 knock-out mice.

  5. Both in supernatant and as purified fusion protein, TL1A (show TNFSF15 Proteins)-Ig binds to TNFRSF25 transfected--but not untransfected--P815 tumor cells as determined by flow cytometry.

  6. TNFRSF25 agonists expand Tregs in vivo and delay cardiac allograft rejection.

  7. TNFRSF25 agonistic antibody and galectin-9 (show LGALS9 Proteins) combination therapy controls herpes simplex virus-induced immunoinflammatory lesions

  8. This is the first description of DR3 regulating virus-specific T-cell function in vivo and uncovers a critical role for DR3 in mediating antiviral immunity.

  9. DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor (show TNF Proteins).

  10. DR3 facilitates clearance of Salmonella typhimurium in vivo.

TNFRSF25 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

Alternative names and synonyms associated with TNFRSF25

  • tumor necrosis factor receptor superfamily, member 25 (TNFRSF25)
  • tumor necrosis factor receptor superfamily, member 25 (Tnfrsf25)
  • APO-3 protein
  • DDR3 protein
  • DR3 protein
  • LARD protein
  • Tnfrsf12 protein
  • TNFRSF25 protein
  • TR3 protein
  • TRAMP protein
  • Wsl protein
  • WSL-1 protein
  • WSL-LR protein

Protein level used designations for TNFRSF25

tumor necrosis factor receptor superfamily, member 25 , apoptosis inducing receptor , apoptosis-inducing receptor AIR , apoptosis-mediating receptor DR3 , apoptosis-mediating receptor TRAMP , death domain receptor 3 soluble form , death receptor beta , lymphocyte-associated receptor of death , protein WSL-1 , tumor necrosis factor receptor superfamily member 25 , tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein) , tumor necrosis factor receptor superfamily, member 12 , translocating chain-association membrane protein , tumor necrosis factor receptor superfamily, member12

489632 Canis lupus familiaris
703744 Macaca mulatta
749145 Pan troglodytes
100594987 Nomascus leucogenys
8718 Homo sapiens
85030 Mus musculus
783432 Bos taurus
500592 Rattus norvegicus
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