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Browse our anti-TNFSF10 (TNFSF10) Antibodies

Full name:
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 Antibodies (TNFSF10)
On are 378 Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Antibodies from 34 different suppliers available. Additionally we are shipping TNFSF10 Proteins (77) and TNFSF10 Kits (47) and many more products for this protein. A total of 521 TNFSF10 products are currently listed.
A330042I21Rik, AI448571, APO-2L, APO2L, CD253, Ly81, TL2, Trail, trail1, xtrail1
list all antibodies Gene Name GeneID UniProt
TNFSF10 8743 P50591
TNFSF10 22035 P50592
TNFSF10 246775  

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Most Popular Reactivities for anti-TNFSF10 (TNFSF10) Antibodies

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anti-Human TNFSF10 Antibodies:

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anti-Rat (Rattus) TNFSF10 Antibodies:

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Top referenced anti-TNFSF10 Antibodies

  1. Human Monoclonal TNFSF10 Primary Antibody for WB - ABIN967538 : Mariani, Matiba, Armandola, Krammer: Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells. in The Journal of cell biology 1997 (PubMed)
    Show all 6 references for ABIN967538

  2. Human Monoclonal TNFSF10 Primary Antibody for IHC (p), WB - ABIN252480 : Müller, Raftery, Kather, Giese, Schönrich: Frontline: Induction of apoptosis and modulation of c-FLIPL and p53 in immature dendritic cells infected with herpes simplex virus. in European journal of immunology 2004 (PubMed)
    Show all 6 references for ABIN252480

  3. Human Polyclonal TNFSF10 Primary Antibody for IF (p), IHC (p) - ABIN673494 : Fang, Zhang, Qi, Fan, Luo, Liu, Tan: Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells. in PLoS ONE 2014 (PubMed)
    Show all 2 references for ABIN673494

  4. Dog (Canine) Polyclonal TNFSF10 Primary Antibody for WB - ABIN2792132 : Wu, Tsai, Lin, Chou, Chen, Yang, Hsu, Hsu: Helicobacter pylori enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in human gastric epithelial cells. in World journal of gastroenterology : WJG 2004 (PubMed)
    Show all 2 references for ABIN2792132

  5. Human Monoclonal TNFSF10 Primary Antibody for Func, FACS - ABIN2749022 : Plasilova, Zivny, Jelinek, Neuwirtova, Cermak, Necas, Andera, Stopka: TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. in Leukemia 2002 (PubMed)

  6. Human Monoclonal TNFSF10 Primary Antibody for FACS - ABIN4897836 : Kalb, Glaser, Stary, Koszik, Stingl: TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)

  7. Human Polyclonal TNFSF10 Primary Antibody for WB - ABIN151524 : Herzer, Carbow, Sydor, Sowa, Biesterfeld, Hofmann, Galle, Gerken, Canbay: Deficiency of the promyelocytic leukemia protein fosters hepatitis C-associated hepatocarcinogenesis in mice. in PLoS ONE 2012 (PubMed)

  8. Human Polyclonal TNFSF10 Primary Antibody for IF, ELISA - ABIN1533756 : Wiley, Schooley, Smolak, Din, Huang, Nicholl, Sutherland, Smith, Rauch, Smith: Identification and characterization of a new member of the TNF family that induces apoptosis. in Immunity 1996 (PubMed)

  9. Human Monoclonal TNFSF10 Primary Antibody for FACS - ABIN1106154 : Bremer, Samplonius, Peipp, van Genne, Kroesen, Fey, Gramatzki, de Leij, Helfrich: Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7. in Cancer research 2005 (PubMed)

More Antibodies against TNFSF10 Interaction Partners

Xenopus laevis Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs, presumably owing to PKC (show PKC Antibodies) activation, as part of the mechanism for RBC (show CACNA1C Antibodies) switching

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. TRAIL can enhance RIP1 (show UQCRFS1 Antibodies) and c-FLIPL (show CFLAR Antibodies) expression in HepG2 cells.

  2. TRAIL might promote hypoxic A549 cell radiosensitivity and induce apoptosis depending on DR5 (show TNFRSF10B Antibodies) to caspase-3 (show CASP3 Antibodies) pathways.

  3. pro-angiogenic responses of TRAIL, vascular endothelial growth-factor-A (VEGF-A (show VEGFA Antibodies)) and fibroblast growth-factor-2 (FGF-2 (show FGF2 Antibodies)) either separately (10 ng/mL) or in combination were compared, followed by the assessment of proliferation, migration and tubule formation using human microvascular endothelial-1 (HMEC-1) cells.

  4. Combined triple actions of the TRAIL, the IAPs inhibitor, AT406, and the c-FLIP (show CFLAR Antibodies) expression inhibitor, rocaglamide (ART), markedly improve TRAIL-induced apoptotic effects in most solid cancer cell lines through the activation of an extrinsic apoptosis pathway

  5. We demonstrate that PBOX-15 can enhance TRAIL-induced apoptosis by upregulation of DR5 (show TNFRSF10B Antibodies), reduction of cellular mitochondrial potential, activation of the caspase (show CASP3 Antibodies) cascade and downregulation of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies), c-FLIP (show CFLAR Antibodies), Mcl-1 (show MCL1 Antibodies) and IAP (show ALPI Antibodies) survival pathways

  6. TRAIL may provide a new strategy for CD133hi CSCs of HCC (show FAM126A Antibodies)-targeted therapies.

  7. The nanovectorization of TRAIL enhanced its binding to both DR4 (show HLADRB4 Antibodies) and DR5 (show TNFRSF10B Antibodies) receptors at 37 degrees C and could potentially sensitized cancer cells to TRAIL induced apoptosis through simultaneous activation of DR4 (show HLADRB4 Antibodies) and DR5 (show TNFRSF10B Antibodies) as described in this paper for the non-small lung carcinoma cell line (H1703), the two hepatocarcinoma cell lines (SK-Hep1, HUH) and the colon carcinoma cell line (HCT116WT).

  8. Manipulating the expression of both miR (show MLXIP Antibodies)-222 and miR (show MLXIP Antibodies)-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR (show MLXIP Antibodies)-25 reduced MEK4 (show MAP2K4 Antibodies) and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR (show MLXIP Antibodies)-25 functioning in thyroid cells.

  9. we found that CQ decreased the expression of Cbl (show CBL Antibodies), an E3 ligase of DR5 (show TNFRSF10B Antibodies), and knock-down of Cbl (show CBL Antibodies) markedly enhanced DR5 (show TNFRSF10B Antibodies) up-regulation. Other lysosomal inhibitors, including monensin and nigericin, also up-regulated DR5 (show TNFRSF10B Antibodies) and sensitized TRAIL-mediated apoptosis

  10. For osteosarcoma and acts through the TRAIL-DR-5 (show TNFRSF10B Antibodies) signaling pathway.

Pig (Porcine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. Data suggest forkhead box protein O1 (FoxO1 (show FOXO1 Antibodies)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (show FASL Antibodies) expression during follicular atresia.

  2. The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (show NOX4 Antibodies)/eNOS (show NOS3 Antibodies)/nitric oxide signaling.

  2. Study reports that loss of the Opg (show TNFSF11 Antibodies) gene results in deterioration of abdominal aortic aneurysms (AAA (show AAAS Antibodies)), possibly through involvement of TRAIL in smooth muscle actin (SMA (show SMN1 Antibodies))-positive cells and myofibroblasts.

  3. PARP1 (show PARP1 Antibodies) acts as a prominent upstream regulator of high mobility group box 1 (show HMGB1 Antibodies)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance

  4. Data suggest that Socs3 (suppressor of cytokine signaling 3 (show SOCS3 Antibodies)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (show MAPK8 Antibodies)/AP-1 (show JUN Antibodies) transcription factor signaling.

  5. These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (show HSP70 Antibodies).

  6. These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald (show RDH11 Antibodies) burns

  7. TRAIL-deficiency in ApoE (show APOE Antibodies)(-/-) mice exacerbates nephropathy and insulin (show INS Antibodies) resistance

  8. Tumor necrosis factor (show TNF Antibodies)-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.

  9. These results suggest that TRAIL inhibits VEGF (show VEGFA Antibodies)-induced angiogenesis by increasing caspase-8 (show CASP8 Antibodies) activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 (show CASP3 Antibodies) activation and endothelial cell cytotoxicity.

  10. TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL (show TNFSF11 Antibodies).

TNFSF10 Antigen Profile

Antigen Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TNFSF10

  • tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) antibody
  • TNF-related apoptosis inducing ligand-like (TRAIL-LIKE) antibody
  • tumor necrosis factor (ligand) superfamily, member 10 (tnfsf10) antibody
  • tumor necrosis factor (ligand) superfamily, member 10 (Tnfsf10) antibody
  • A330042I21Rik antibody
  • AI448571 antibody
  • APO-2L antibody
  • APO2L antibody
  • CD253 antibody
  • Ly81 antibody
  • TL2 antibody
  • Trail antibody
  • trail1 antibody
  • xtrail1 antibody

Protein level used designations for TNFSF10

tumor necrosis factor ligand superfamily member 10 , TNF-related apoptosis inducing ligand , TNF-related apoptosis inducing ligand-like protein , Tnf-alpha related apoptosis inducing ligand , TNF-related apoptosis-inducing ligand 1 , tumor necrosis factor related apoptosis inducing ligand 1 , Apo-2 ligand , TNF-related apoptosis inducing ligand TRAIL , chemokine tumor necrosis factor ligand superfamily member 10 , tumor necrosis factor (ligand) family, member 10 , tumor necrosis factor apoptosis-inducing ligand splice variant delta , tumor necrosis factor-related apoptosis-inducing ligand , TNF-related apoptosis-inducing ligand , TRAIL/APO2L

378894 Gallus gallus
395283 Gallus gallus
100174789 Felis catus
100316914 Xenopus laevis
8743 Homo sapiens
100174780 Canis lupus familiaris
406191 Sus scrofa
22035 Mus musculus
246775 Rattus norvegicus
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