TRAIL Products
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
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Featured TRAIL Categories
TRAIL Antibodies
High quality antibodies with extensive validation data.
TRAIL ELISA Kits
Reliable ELISA kits for a wide range of species.
TRAIL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TRAIL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN3023015
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (2)
- (3)
Cat. No.
ABIN673494
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, Func
Validations
- (1)
- (2)
Cat. No.
ABIN2749022
Quantity
0.1 mg
Datasheet
Datasheet
Recommended TRAIL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960244
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6960245
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6999519
Quantity
96 tests
Datasheet
Datasheet
Recommended TRAIL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (5)
Cat. No.
ABIN7275774
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275775
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1323209
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TRAIL products
: "Heterogeneous intracellular TRAIL-receptor distribution predicts poor outcome in breast cancer patients." in: Journal of molecular medicine (Berlin, Germany), Vol. 97, Issue 8, pp. 1155-1167, (2020) (PubMed).: "CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway." in: International journal of molecular medicine, Vol. 45, Issue 2, pp. 324-332, (2020) (PubMed).
: "Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice." in: Scientific reports, Vol. 7, Issue 1, pp. 1898, (2018) (PubMed).
: "Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo." in: Oncology letters, Vol. 15, Issue 4, pp. 5744-5750, (2018) (PubMed).
: "Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors." in: Molecular and cellular biology, Vol. 37, Issue 10, (2017) (PubMed).
: "Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients." in: Scientific reports, Vol. 7, pp. 44544, (2017) (PubMed).
: "Stretch-induced apoptosis in rat alveolar epithelial cells is mediated by the intrinsic mitochondrial pathway." in: Experimental lung research, Vol. 43, Issue 1, pp. 49-56, (2017) (PubMed).
: "Peg-Interferon Lambda Treatment Induces Robust Innate and Adaptive Immunity in Chronic Hepatitis B Patients. ..." in: Frontiers in immunology, Vol. 8, pp. 621, (2017) (PubMed).
: "A Histone Deacetylase Inhibitor, OBP-801, and Celecoxib Synergistically Inhibit the Cell Growth with Apoptosis via a DR5-Dependent Pathway in Bladder Cancer Cells." in: Molecular cancer therapeutics, Vol. 15, Issue 9, pp. 2066-75, (2016) (PubMed).
: "Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease ..." in: Apoptosis : an international journal on programmed cell death, Vol. 21, Issue 6, pp. 699-707, (2016) (PubMed).
Synonyms and alternative names related to TRAIL
TNF superfamily member 10 (TNFSF10), tumor necrosis factor (ligand) superfamily, member 10 (Tnfsf10), TNF superfamily member 10 (Tnfsf10), tumor necrosis factor superfamily member 10 (TNFSF10), TNF superfamily member 10 S homeolog (tnfsf10.S), TNF superfamily member 10 (tnfsf10), A330042I21Rik, AI448571, Apo-2L, APO-2L, apo-2l, APO2L, apo2l, CD253, cd253, Ly81, TL2, tl2, tnfsf10l2, TNLG6A, TRAIL, Trail, trail, trail1, xtrail1, zgc:92320Protein level used designations for TRAIL
- Apo-2 ligand
- TNF-related apoptosis inducing ligand TRAIL
- chemokine tumor necrosis factor ligand superfamily member 10
- tumor necrosis factor (ligand) family, member 10
- tumor necrosis factor apoptosis-inducing ligand splice variant delta
- tumor necrosis factor ligand superfamily member 10
- TNF-related apoptosis inducing ligand
- TNF-related apoptosis-inducing ligand
- TRAIL/APO2L
- tumor necrosis factor-related apoptosis-inducing ligand
- TNF-related apoptosis-inducing ligand 1
- tumor necrosis factor related apoptosis inducing ligand 1
- DL2
- TNFSF10-1
- tumor necrosis factor (ligand) superfamily, member 10 like 2
- tumor necrosis factor (ligand) superfamily, member 10
- tumor necrosis factor ligand 6A
- tumor necrosis factor superfamily member 10
Did you look for something else?
- TRAFs and NIK-Associated Protein
- Trafficking Protein Particle Complex 13
- TRAFD1
- TRAF7
- TRAF6
- TRAF5
- TRAF3IP3
- TRAF3IP2
- TRAF3IP1
- TRAF3
- TRAF2 and NCK Interacting Kinase
- TRAF2
- TRAF1
- TRADD
- Trace Amine Associated Receptor 8
- TRAC
- TRABD2B
- TRABD2A
- TRABD
- TraB
- TRAIP
- TRAJ17
- TraK
- TRAK1
- TRAK2
- TRAM1
- TRAM1L1
- TRAM2
- Tramadol
- Trans-Sialidase
- Transcription Factor 24
- Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box)
- Transcription Factor MafK
- Transcription Termination Factor rho
- Transcriptional Adaptor 3
- Transferrin
- Transferrin Receptor
- Transferrin Receptor 2
- Transforming Growth Factor, beta 2
- Transgelin
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