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Human TNFSF10 Protein expressed in Wheat germ - ABIN1323209
Borbone, De Rosa, Siciliano, Altucci, Croce, Fusco: Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells. in The Journal of clinical endocrinology and metabolism 2013
xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs (show SSU1 Proteins), presumably owing to PKC activation, as part of the mechanism for RBC (show CACNA1C Proteins) switching
Antagonistic antibodies against the death receptors demonstrated that Apo2L/TRAIL mediated its apoptotic signals through activation of the TRAIL-R2 in PTHrP expressing breast cancer cells
Co-treatment of carboplatin and autophagy inhibitor chloroquine increased lung tissue infiltration by CD4 (show CD4 Proteins)(+), FoxP3 (show FOXP3 Proteins)(+) lymphocytes and antigen-specific immune activation. Subsequent ex vivo experiments showed the activation of carboplatin related TRAIL-dependent apoptosis through caspase 8 (show CASP8 Proteins) and a synergistic role of miR (show MLXIP Proteins)-155 in lung tissue infiltration by CD4 (show CD4 Proteins)(+), and FoxP3 (show FOXP3 Proteins)(+) lymphocytes.
Caspase-8 can serve in two distinct roles in response to TRAIL receptor engagement, as a scaffold for assembly of a Caspase-8-FADD-RIPK1 "FADDosome" complex, leading to NFkappaB-dependent inflammation, or as a protease that promotes apoptosis.
Endogenous TRAIL/TRAIL-R-mediated CCL2 (show CCL2 Proteins) secretion promotes accumulation of tumor-supportive immune cells in the cancer microenvironment.
Fn14 (show TNFRSF12A Proteins).TRAIL can be converted into a highly effective TRAIL oligomer upon binding to TWEAK (show TNFSF12 Proteins) which induces lymphoblast apoptosis.
BAY61-3606 sensitizes colon cancer cells to TRAIL-induced apoptosis by up-regulating DR4 (show HLADRB4 Proteins) expression in p53 (show TP53 Proteins)-dependent manner and inhibiting NF-kappaB (show NFKB1 Proteins) activity.
High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 (show TNFRSF10B Proteins) cross-linking and increases antitumour effect against colon cancer cells and xenograft tumors.
results suggest that miR (show MLXIP Proteins)-223 increases the sensitivity of TNBCSCs to TRAIL-induced apoptosis by targeting HAX-1 (show HAX1 Proteins)
The results suggested that miR (show MLXIP Proteins)-138 regulates the interferon (show IFNA Proteins)-stimulated gene 15 expression by directly targeting the 3' untranslated region of interferon (show IFNA Proteins)-stimulated gene 15 and modulates the sensitivity to TRAIL-induced apoptosis.
these results demonstrate that high HOTAIR levels increase the resistance of pancreatic cancer cells to TRAIL-induced apoptosis via epigenetic regulation of DR5 (show TNFRSF10B Proteins) expression.
Data suggest forkhead box protein O1 (FoxO1 (show FOXO1 Proteins)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.
The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.
Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation.
Diabetes significantly increased OPG (show TNFSF11 Proteins) and the OPG (show TNFSF11 Proteins)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (show TNFSF11 Proteins) and reduced TRAIL expression, thus increasing cardiac OPG (show TNFSF11 Proteins)/TRAIL ratio.
TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (show NOX4 Proteins)/eNOS (show NOS3 Proteins)/nitric oxide signaling.
Study reports that loss of the Opg (show TNFSF11 Proteins) gene results in deterioration of abdominal aortic aneurysms (AAA (show AAAS Proteins)), possibly through involvement of TRAIL in smooth muscle actin (SMA (show SMN1 Proteins))-positive cells and myofibroblasts.
PARP1 (show PARP1 Proteins) acts as a prominent upstream regulator of high mobility group box 1 (show HMGB1 Proteins)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance
Data suggest that Socs3 (suppressor of cytokine signaling 3 (show SOCS3 Proteins)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (show MAPK8 Proteins)/AP-1 (show JUN Proteins) transcription factor signaling.
These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (show HSP70 Proteins).
These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald (show RDH11 Proteins) burns
TRAIL-deficiency in ApoE (show APOE Proteins)(-/-) mice exacerbates nephropathy and insulin (show INS Proteins) resistance
Tumor necrosis factor (show TNF Proteins)-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
tumor necrosis factor ligand superfamily member 10
, TNF-related apoptosis inducing ligand
, TNF-related apoptosis inducing ligand-like protein
, Tnf-alpha related apoptosis inducing ligand
, TNF-related apoptosis-inducing ligand 1
, tumor necrosis factor related apoptosis inducing ligand 1
, Apo-2 ligand
, TNF-related apoptosis inducing ligand TRAIL
, chemokine tumor necrosis factor ligand superfamily member 10
, tumor necrosis factor (ligand) family, member 10
, tumor necrosis factor apoptosis-inducing ligand splice variant delta
, tumor necrosis factor-related apoptosis-inducing ligand
, TNF-related apoptosis-inducing ligand