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TRAIL Proteins

(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
TRAIL Protein (AA 114-281) TRAIL Protein (AA 114-281) TRAIL Protein (AA 114-281) (ABIN7275774)

TNFSF10 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC

TRAIL Protein (Trimer) (His-DYKDDDDK Tag) TRAIL Protein (Trimer) (His-DYKDDDDK Tag) TRAIL Protein (Trimer) (His-DYKDDDDK Tag) (ABIN7275775)

TNFSF10 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC

TRAIL Protein (AA 1-281) (GST tag) TRAIL Protein (AA 1-281) (GST tag) TRAIL Protein (AA 1-281) (GST tag) (ABIN1323209)

TNFSF10 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

TRAIL Proteins by Grade

Find TRAIL Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

TRAIL Proteins by Origin

Find TRAIL Proteins for a variety of species such as anti-Human TRAIL, anti-Mouse TRAIL, anti-Rat TRAIL. The species listed below are among those available. Click on a link to go to the corresponding products.

TRAIL Proteins by Source

Here you will find TRAIL Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

TRAIL Proteins by Protein Type

Here you can find TRAIL Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

TRAIL Proteins by Application

Find TRAIL Proteins validated for a specific application such as SDS, WB, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

TRAIL Proteins by Biological Activity

Find TRAIL Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular TRAIL Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (5)
Cat. No. ABIN7275774
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275775
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1323209
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293T Cells
Validations
  • (2)
Cat. No. ABIN4369885
Quantity 2 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7275783
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (3)
Cat. No. ABIN1344417
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125525
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3074138
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3134333
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3098448
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134332
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
  • (1)
Cat. No. ABIN1047805
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN1344414
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2018415
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7319100
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our TRAIL Proteins

Borbone, De Rosa, Siciliano, Altucci, Croce, Fusco: "Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells." in: The Journal of clinical endocrinology and metabolism, Vol. 98, Issue 6, pp. E1031-40, (2013) (PubMed).

Koschny, Ganten, Sykora, Haas, Sprick, Kolb, Stremmel, Walczak: "TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window." in: Hepatology (Baltimore, Md.), Vol. 45, Issue 3, pp. 649-58, (2007) (PubMed).

Ganten, Koschny, Sykora, Schulze-Bergkamen, Büchler, Haas, Schader, Untergasser, Stremmel, Walczak: "Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 8, pp. 2640-6, (2006) (PubMed).

Wissink, Verbrugge, Vink, Schader, Schaefer, Walczak, Borst, Verheij: "TRAIL enhances efficacy of radiotherapy in a p53 mutant, Bcl-2 overexpressing lymphoid malignancy." in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 80, Issue 2, pp. 214-22, (2006) (PubMed).

Pitti, Marsters, Ruppert, Donahue, Moore, Ashkenazi: "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12687-90, (1996) (PubMed).

Aliases for TRAIL Proteins

TNF superfamily member 10 (TNFSF10) Proteins
tumor necrosis factor (ligand) superfamily, member 10 (Tnfsf10) Proteins
TNF superfamily member 10 (Tnfsf10) Proteins
tumor necrosis factor superfamily member 10 (TNFSF10) Proteins
TNF superfamily member 10 S homeolog (tnfsf10.S) Proteins
TNF superfamily member 10 (tnfsf10) Proteins
A330042I21Rik Proteins
AI448571 Proteins
Apo-2L Proteins
APO-2L Proteins
apo-2l Proteins
APO2L Proteins
apo2l Proteins
CD253 Proteins
cd253 Proteins
Ly81 Proteins
TL2 Proteins
tl2 Proteins
tnfsf10l2 Proteins
TNLG6A Proteins
TRAIL Proteins
Trail Proteins
trail Proteins
trail1 Proteins
xtrail1 Proteins
zgc:92320 Proteins
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