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Browse our TNFSF10 Proteins (TNFSF10)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 Proteins (TNFSF10)
On are 77 Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Proteins from 19 different suppliers available. Additionally we are shipping TNFSF10 Antibodies (378) and TNFSF10 Kits (47) and many more products for this protein. A total of 521 TNFSF10 products are currently listed.
A330042I21Rik, AI448571, APO-2L, APO2L, CD253, Ly81, TL2, Trail, trail1, xtrail1
list all proteins Gene Name GeneID UniProt
TNFSF10 8743 P50591
TNFSF10 22035 P50592
Rat TNFSF10 TNFSF10 246775  

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TNFSF10 Proteins (TNFSF10) by Origin

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Top referenced TNFSF10 Proteins

  1. Human TNFSF10 Protein expressed in Escherichia coli (E. coli) - ABIN666704 : Janssen, Droin, Lemmens, Pinkoski, Bensinger, Ehst, Griffith, Green, Schoenberger: CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. in Nature 2005 (PubMed)
    Show all 2 references for ABIN666704

  2. Mouse (Murine) TNFSF10 Protein expressed in Escherichia coli (E. coli) - ABIN2007441 : Wiley, Schooley, Smolak, Din, Huang, Nicholl, Sutherland, Smith, Rauch, Smith: Identification and characterization of a new member of the TNF family that induces apoptosis. in Immunity 1996 (PubMed)
    Show all 2 references for ABIN2007441

  3. Human TNFSF10 Protein expressed in Escherichia coli (E. coli) - ABIN1047804 : Pitti, Marsters, Ruppert, Donahue, Moore, Ashkenazi: Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. in The Journal of biological chemistry 1996 (PubMed)

  4. Human TNFSF10 Protein expressed in Wheat germ - ABIN1323209 : Borbone, De Rosa, Siciliano, Altucci, Croce, Fusco: Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells. in The Journal of clinical endocrinology and metabolism 2013 (PubMed)

More Proteins for TNFSF10 Interaction Partners

Xenopus laevis Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs (show SSU1 Proteins), presumably owing to PKC activation, as part of the mechanism for RBC (show CACNA1C Proteins) switching

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. TRAIL can enhance RIP1 (show UQCRFS1 Proteins) and c-FLIPL (show CFLAR Proteins) expression in HepG2 cells.

  2. TRAIL might promote hypoxic A549 cell radiosensitivity and induce apoptosis depending on DR5 (show TNFRSF10B Proteins) to caspase-3 (show CASP3 Proteins) pathways.

  3. pro-angiogenic responses of TRAIL, vascular endothelial growth-factor-A (VEGF-A (show VEGFA Proteins)) and fibroblast growth-factor-2 (FGF-2 (show FGF2 Proteins)) either separately (10 ng/mL) or in combination were compared, followed by the assessment of proliferation, migration and tubule formation using human microvascular endothelial-1 (HMEC-1) cells.

  4. Combined triple actions of the TRAIL, the IAPs inhibitor, AT406, and the c-FLIP (show CFLAR Proteins) expression inhibitor, rocaglamide (ART), markedly improve TRAIL-induced apoptotic effects in most solid cancer cell lines through the activation of an extrinsic apoptosis pathway

  5. We demonstrate that PBOX-15 can enhance TRAIL-induced apoptosis by upregulation of DR5 (show TNFRSF10B Proteins), reduction of cellular mitochondrial potential, activation of the caspase (show CASP3 Proteins) cascade and downregulation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins), c-FLIP (show CFLAR Proteins), Mcl-1 (show MCL1 Proteins) and IAP (show ALPI Proteins) survival pathways

  6. TRAIL may provide a new strategy for CD133hi CSCs of HCC (show FAM126A Proteins)-targeted therapies.

  7. The nanovectorization of TRAIL enhanced its binding to both DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) receptors at 37 degrees C and could potentially sensitized cancer cells to TRAIL induced apoptosis through simultaneous activation of DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) as described in this paper for the non-small lung carcinoma cell line (H1703), the two hepatocarcinoma cell lines (SK-Hep1, HUH) and the colon carcinoma cell line (HCT116WT).

  8. Manipulating the expression of both miR (show MLXIP Proteins)-222 and miR (show MLXIP Proteins)-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR (show MLXIP Proteins)-25 reduced MEK4 (show MAP2K4 Proteins) and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR (show MLXIP Proteins)-25 functioning in thyroid cells.

  9. we found that CQ decreased the expression of Cbl (show CBL Proteins), an E3 ligase of DR5 (show TNFRSF10B Proteins), and knock-down of Cbl (show CBL Proteins) markedly enhanced DR5 (show TNFRSF10B Proteins) up-regulation. Other lysosomal inhibitors, including monensin and nigericin, also up-regulated DR5 (show TNFRSF10B Proteins) and sensitized TRAIL-mediated apoptosis

  10. For osteosarcoma and acts through the TRAIL-DR-5 (show TNFRSF10B Proteins) signaling pathway.

Pig (Porcine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. Data suggest forkhead box protein O1 (FoxO1 (show FOXO1 Proteins)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.

  2. The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

  1. TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (show NOX4 Proteins)/eNOS (show NOS3 Proteins)/nitric oxide signaling.

  2. Study reports that loss of the Opg (show TNFSF11 Proteins) gene results in deterioration of abdominal aortic aneurysms (AAA (show AAAS Proteins)), possibly through involvement of TRAIL in smooth muscle actin (SMA (show SMN1 Proteins))-positive cells and myofibroblasts.

  3. PARP1 (show PARP1 Proteins) acts as a prominent upstream regulator of high mobility group box 1 (show HMGB1 Proteins)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance

  4. Data suggest that Socs3 (suppressor of cytokine signaling 3 (show SOCS3 Proteins)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (show MAPK8 Proteins)/AP-1 (show JUN Proteins) transcription factor signaling.

  5. These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (show HSP70 Proteins).

  6. These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald (show RDH11 Proteins) burns

  7. TRAIL-deficiency in ApoE (show APOE Proteins)(-/-) mice exacerbates nephropathy and insulin (show INS Proteins) resistance

  8. Tumor necrosis factor (show TNF Proteins)-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.

  9. These results suggest that TRAIL inhibits VEGF (show VEGFA Proteins)-induced angiogenesis by increasing caspase-8 (show CASP8 Proteins) activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 (show CASP3 Proteins) activation and endothelial cell cytotoxicity.

  10. TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL (show TNFSF11 Proteins).

TNFSF10 Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TNFSF10

  • tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10)
  • TNF-related apoptosis inducing ligand-like (TRAIL-LIKE)
  • tumor necrosis factor (ligand) superfamily, member 10 (tnfsf10)
  • tumor necrosis factor (ligand) superfamily, member 10 (Tnfsf10)
  • A330042I21Rik protein
  • AI448571 protein
  • APO-2L protein
  • APO2L protein
  • CD253 protein
  • Ly81 protein
  • TL2 protein
  • Trail protein
  • trail1 protein
  • xtrail1 protein

Protein level used designations for TNFSF10

tumor necrosis factor ligand superfamily member 10 , TNF-related apoptosis inducing ligand , TNF-related apoptosis inducing ligand-like protein , Tnf-alpha related apoptosis inducing ligand , TNF-related apoptosis-inducing ligand 1 , tumor necrosis factor related apoptosis inducing ligand 1 , Apo-2 ligand , TNF-related apoptosis inducing ligand TRAIL , chemokine tumor necrosis factor ligand superfamily member 10 , tumor necrosis factor (ligand) family, member 10 , tumor necrosis factor apoptosis-inducing ligand splice variant delta , tumor necrosis factor-related apoptosis-inducing ligand , TNF-related apoptosis-inducing ligand , TRAIL/APO2L

378894 Gallus gallus
395283 Gallus gallus
100174789 Felis catus
100316914 Xenopus laevis
8743 Homo sapiens
100174780 Canis lupus familiaris
406191 Sus scrofa
22035 Mus musculus
246775 Rattus norvegicus
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