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Zebrafish larvae lacking beta1AR expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
ghrelin (show GHRL Proteins) has a critical role in preventing hypoglycemia and promoting survival during severe caloric restriction, a process that requires cell-expressed beta1AR
knocking out of the beta1/2 (show TFAP2B Proteins) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.
Our findings that BAG3 (show BAG3 Proteins) is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2 (show CA2 Proteins)+) channel provide novel insight into the role of BAG3 (show BAG3 Proteins) in cardiomyopathies and increased arrhythmia risks in heart failure.
Galphai2 (show GNAI2 Proteins) deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.
Knockout of the C5aR1 (show C5AR1 Proteins) attenuated the effect of beta1-AR in the heart, suggesting an association between the beta1-AR and C5aR1 (show C5AR1 Proteins), although further investigation is required to determine if this is a direct or causal association
Partial gap junction uncoupling increased propensity and amplitude of Ca(2 (show CA2 Proteins)+) alternans, and made them more sensitive to reversal by beta-AR activation, as in isolated myocytes.
These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response.
Myocardial adrenergic receptor beta 1 preferentially associates with AC5 (show ADCY5 Proteins).
role of beta-ARs (show SLURP1 Proteins) in early muscle regeneration
Phosphorylation of beta1-AR by PKA stimulates active Ca(2 (show CA2 Proteins)+)influx through TRPV5 (show TRPV5 Proteins).
Analyzing the functional relevance of individual sites using phosphosite-deficient receptor mutants we found phosphorylation of the ADRB1 at Ser461/Ser462 in the distal part of the C-terminus to determine beta-arrestin2 (show ARRB2 Proteins) recruitment and receptor internalization
Studied frequency of ADRB1 Arginine389Glycine (Arg389Gly) and Cytochrome p450 2D6 (show CYP2D6 Proteins)*10 (Cyp2D6 (show CYP2D6 Proteins)*10) polymorphism in cases of heart failure-reduced ejection fraction (HFREF), and to evaluate the influence of the polymorphisms in response to beta-blocker (BB) therapy; found a statistically significant association was observed with CC genotype and Glisin-Glisin (GG) genotype.
Among individuals with previous small artery ischemic stroke, the ADRB1 Gly49 polymorphism was associated with major adverse cardiovascular events, particularly small artery ischemic stroke, a risk that may be increased among beta-blocker-treated individuals.
ADRB1 SNPs were associated with myocardial infarction susceptibility, blood pressure and plasma lipids.
the beta adrenoreceptor Gly 49 allele of the beta1 -adrenergic receptor Ser (show SIGLEC1 Proteins)(49) Gly polymorphisms may increase the risk of implantable cardioverter-defibrillators shock in patients with heart failure, independent of beta-blocker dosage
This study demonstrates that the polypeptide GalNAc-transferase 2 (GalNAc-T2 (show GALNT2 Proteins)) specifically O-glycosylates beta 1-adrenergic receptor at five residues in the extracellular N terminus, including the Ser (show SIGLEC1 Proteins)-49 residue at the location of the common S49G single-nucleotide polymorphism.
The minor alleles of ADRB1 and ADRB3 (show ADRB3 Proteins) were significantly underrepresented in kinesiology students compared with nonmajors.
The ADRB1 Gly389X genotype showed greater response to bisoprolol than the Arg389Arg genotype, suggesting the potential of individually tailoring beta-blocker therapy according to genotype in Korean heart failure patients.
The multiplex SNaPshot method allows for specific and accurate detection of CYP2D6 (show CYP2D6 Proteins) genotypes and ADRB1 genotypes and haplotypes. This platform is simple and efficient and suited for high throughput.
Suggest a common regulatory pattern for the beta(1)-AR/GRK5 (show GRK5 Proteins) which is independent of cellular type or pathology.
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.
beta-adrenergic receptor kinase 1
, adrenergic, beta-1-, receptor
, adrenoceptor beta 1
, adrenoceptor beta 3
, beta adrenergic receptor kinase 1
, beta-1-adrenergic receptor
, beta-1 adrenergic receptor
, tripartite motif-containing 75
, adrenergic, beta, receptor kinase 1
, beta-adrenergic receptor kinase 1-like
, beta1-adrenergic G-protein-coupled receptor
, beta 1-AR
, beta-1 adrenoceptor
, beta-1 adrenoreceptor
, cardiac beta adrenergic receptor
, beta 1 adrenergic receptor
, adrenergic receptor, beta 1
, beta 1-adrenergic receptor beta 1-AR
, beta 1 adrenergic protein
, Beta-1 adrenergic receptor
, G-protein-coupled hormone receptor
, beta 1-adrenergic receptor