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CCR2 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits.
These data suggest that CCR1/CCR2B could be involved in clearing EBV-infected latency III B cells in immunocompetent individuals via directing the migration of these cells and attracting the chemokines-expressing immune cells.
systemic mRNA expression of CCR2 strongly differentiated children who failed to achieve asthma control with triamcinolone administration
Basophil migration into skin lesions of Systemic Lupus Erythematosus patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils.
The CCR2 (+190 G/A) GG genotype frequencies for patients were significantly higher in the stage III-IV cancer group ( p = 0.036), and A allele carriers were significantly higher in the stage I-II ovarian cancer group.
tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment
The findings of the work indicate a role for Galphaq (show GNAQ ELISA Kits) and/or Galpha14 and in CCR2a/CCR2b-stimulated Rho A (show RHOA ELISA Kits) GTPase (show RACGAP1 ELISA Kits)-mediated serum response factor activation.
Endogenous TRAIL/TRAIL-R-mediated CCL2 (show CCL2 ELISA Kits) secretion promotes accumulation of tumor-supportive immune cells in the cancer microenvironment.
CCL2 (show CCL2 ELISA Kits)/CCR2 axis is expressed in the majority of monocytoid Acute myeloid leukemia (show BCL11A ELISA Kits) blasts
CCR2B and beta2AR (show ADRB2 ELISA Kits) signals to FLNa (show FLNA ELISA Kits) to stimulate its endocytosis and recycling to the plasma membrane.
Suggest role for CCR2 expression in podocytes to mediate diabetic renal injury, independent of monocyte/macrophage recruitment.
CCL2 recruits T cells into the brain in a CCR2-independent manner.
in vitro and in vivo results show that CCR2 intrinsically mediates the expression of inflammatory T cell cytokines, and its absence on T cells results in attenuated colitis progression
CCR2 expression on bone marrow-derived cells, likely macrophages, is essential to muscle regeneration independent of TLR signaling, aging, and sex.
we demonstrated that CX3CR1 (show CX3CR1 ELISA Kits)(Lo)CCR2(Hi) monocytes were recruited to the GBM, where they transitioned to CX3CR1 (show CX3CR1 ELISA Kits)(Hi)CCR2(Lo) macrophages and CX3CR1 (show CX3CR1 ELISA Kits)(Hi)CCR2(-) microglia-like cells. Infiltrating macrophages/monocytes constituted approximately 85% of the total TAM (show CCNA1 ELISA Kits) population, with resident microglia accounting for the approximately 15% remaining.
we characterized a novel regulatory network in macrophages, in which CCR2 activates PI3K-AKT (show AKT1 ELISA Kits)-mTOR (show FRAP1 ELISA Kits) signaling to mediate HIF-1alpha (show HIF1A ELISA Kits) expression, which then drives VEGF-C (show VEGFC ELISA Kits) expression to promote lymphangiogenesis.
CXCR4 (show CXCR4 ELISA Kits), CCR2, and CX3CR1 (show CX3CR1 ELISA Kits) direct dendritic cell precursors from the bone marrow to the lung differentially.
The findings suggest that CCR2 deficiency does not provide a sustained benefit and that Ly6C(low) macrophages may contribute to the progressive fibrosis and dysfunction of mdx (show DMD ELISA Kits)(5cv) diaphragm.
In Ccr2(-/-) mice, a damaged microglia recruitment was shown in retina and this could protect the visual function in electroretinogram and alleviate the photoreceptor apoptosis.
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
C-C chemokine receptor type 2
, MCP-1 receptor
, monocyte chemoattractant protein 1 receptor
, monocyte chemotactic protein 1 receptor
, C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
, C-C CKR-2
, JE/FIC receptor
, MIP-1 alphaR
, chemoattractant protein-1 receptor
, chemokine (C-C) receptor 2
, chemokine receptor CCR2
, chemokine receptor