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Bin1 (show BIN1 ELISA Kits)-N-BAR domains assemble into scaffolds of low long-range order that form flexible membrane tubule in the sarcolemma
CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity.
High expression of CCR6 is associated with cutaneous T-cell lymphoma.
CCR6(-) regulatory T cells blunt the restoration of gut (show GUSB ELISA Kits) Th17 cells along the CCR6-CCL20 (show CCL20 ELISA Kits) axis in treated HIV-1-infected patients.
results provide a potential explanation for involvement of the CCL20 (show CCL20 ELISA Kits)-CCR6 system in the trafficking of IL-17 (show IL17A ELISA Kits)-producing cells to degenerated IVD (show IVD ELISA Kits) tissues
The percentage of CXCR3 (show CXCR3 ELISA Kits)(+) CD4 (show CD4 ELISA Kits)(+) TEM (show CYLD ELISA Kits) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG ELISA Kits)(+) CD4 (show CD4 ELISA Kits)(+) TCM cells expressing CCR6(+) or CCR4 (show CCR4 ELISA Kits)(+)CXCR3 (show CXCR3 ELISA Kits)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
High CCR6 expression is associated with B-lymphoblastic lymphoma with inflammation.
CCR6 expression was higher in cells derived from node-positive cases and highest expression was in cells derived from metastatic cases of colon cancer.
The study suggests that a genetic interaction between DPP4 (show DPP4 ELISA Kits) and CCR6 is involved in RA susceptibility
point mutations in CCR6 can result in either a gain or loss of receptor function
Study identified protein and gene expression of chemokine receptor 6 in the hippocampus of Swiss mice with immunohistochemistry and RT-PCR, showed that CCR6 may be involved in normal neuronal activity in the hippocampus and play an important role in maintenance of the status epilepticus.
these data indicate that CCL20 (show CCL20 ELISA Kits)/CCR6 signaling may play an important role in regulating bone mass accrual, potentially by modulating osteoblast maturation, survival, and the recruitment of osteoblast-supporting cells.
CCR6 is upregulated rapidly within hours on the protein or mRNA level after activation in vitro.
These findings identify a crucial role for CCR6 in promoting LP-mononuclear phagocytes to associate with the intestinal epithelium in the steady state to perform multiple functions promoting gut (show GUSB ELISA Kits) immune homeostasis.
data suggest that gammadeltaT17 cells are completely dependent on CCR6 for homing to psoriasiform skin. Thus, CCR6 may constitute a novel target for a mechanistically distinct therapeutic approach to treating psoriasis.
Data (including data from studies using knockout mice or cells from knockout mice) suggest that HuR (show ELAVL1 ELISA Kits) post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR (show ELAVL1 ELISA Kits) reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (HuR (show ELAVL1 ELISA Kits) = Hu antigen R (show ELAVL1 ELISA Kits))
CCR6 deficiency affects hepatic inflammatory cell recruitment resulting in the promotion of hepatic inflammation and fibrosis.
in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of Peyer's patches.
CCR6 might be crucial for optimal development of Th2 immune responses.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
chemokine (C-C motif) receptor 6
, C-C chemokine receptor type 6
, CC chemokine receptor 6
, c-C chemokine receptor type 6-like
, G protein-coupled receptor 29
, G-protein coupled receptor 29
, LARC receptor
, chemokine (C-C) receptor 6
, chemokine receptor-like 3
, seven-transmembrane receptor, lymphocyte, 22