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CCR6(-) regulatory T cells blunt the restoration of gut (show GUSB ELISA Kits) Th17 cells along the CCR6-CCL20 (show CCL20 ELISA Kits) axis in treated HIV-1-infected patients.
results provide a potential explanation for involvement of the CCL20 (show CCL20 ELISA Kits)-CCR6 system in the trafficking of IL-17 (show IL17A ELISA Kits)-producing cells to degenerated IVD (show IVD ELISA Kits) tissues
The percentage of CXCR3 (show CXCR3 ELISA Kits)(+) CD4 (show CD4 ELISA Kits)(+) TEM (show CYLD ELISA Kits) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG ELISA Kits)(+) CD4 (show CD4 ELISA Kits)(+) TCM cells expressing CCR6(+) or CCR4 (show CCR4 ELISA Kits)(+)CXCR3 (show CXCR3 ELISA Kits)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
High CCR6 expression is associated with B-lymphoblastic lymphoma with inflammation.
CCR6 expression was higher in cells derived from node-positive cases and highest expression was in cells derived from metastatic cases of colon cancer.
The study suggests that a genetic interaction between DPP4 (show DPP4 ELISA Kits) and CCR6 is involved in RA susceptibility
point mutations in CCR6 can result in either a gain or loss of receptor function
Rheumatoid arthritis-associated double nucleotide polymorphism in CCR6 regulates CCR6 via PARP-1 (show PARP1 ELISA Kits).
This study evaluated the role of CCL20 (show CCL20 ELISA Kits) and CCR6 in the regulation of laryngeal neoplasms; it showed that these proteins acted on proliferation and metastasis via the p38 (show CRK ELISA Kits) pathway and multiple microRNAs.
CCR6 expression may be a novel biomarker for predicting clinical outcomes for gastric cancer patients.
data suggest that gammadeltaT17 cells are completely dependent on CCR6 for homing to psoriasiform skin. Thus, CCR6 may constitute a novel target for a mechanistically distinct therapeutic approach to treating psoriasis.
Data (including data from studies using knockout mice or cells from knockout mice) suggest that HuR (show ELAVL1 ELISA Kits) post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR (show ELAVL1 ELISA Kits) reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (HuR (show ELAVL1 ELISA Kits) = Hu antigen R (show ELAVL1 ELISA Kits))
CCR6 deficiency affects hepatic inflammatory cell recruitment resulting in the promotion of hepatic inflammation and fibrosis.
in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of Peyer's patches.
CCR6 might be crucial for optimal development of Th2 immune responses.
This study delineated for the first time a role for CCR6 in the development of breast cancer.
results suggest a key role for CD28 (show CD28 ELISA Kits) costimulation in promoting a central Treg to eTreg transition with appropriate upregulation of chemokine (show CCL1 ELISA Kits) receptors such as CCR6 that are required for tissue homing
CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.
these data indicate that CCR6 has a supplementary role in coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for normal nTreg development.
CCR6 deficieny leads to a diminished cerebral immune response in experimental pneumococcal meningitis.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
chemokine (C-C motif) receptor 6
, C-C chemokine receptor type 6
, CC chemokine receptor 6
, c-C chemokine receptor type 6-like
, G protein-coupled receptor 29
, G-protein coupled receptor 29
, LARC receptor
, chemokine (C-C) receptor 6
, chemokine receptor-like 3
, seven-transmembrane receptor, lymphocyte, 22