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Browse our PKD2 Proteins (PKD2)

Full name:
Protein Kinase D2 Proteins (PKD2)
On are 11 Protein Kinase D2 (PKD2) Proteins from 6 different suppliers available. Additionally we are shipping PKD2 Antibodies (126) and PKD2 Kits (11) and many more products for this protein. A total of 156 PKD2 products are currently listed.
AI325941, APKD2, nPKC-D2, Pc-2, PC2, PKD2, PKD4, PRKD2, RGD1308054, TRPP2
list all proteins Gene Name GeneID UniProt
PKD2 5311 Q13563
PKD2 101540 Q8BZ03
Rat PKD2 PKD2 292658 Q5XIS9

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PKD2 Proteins (PKD2) by Origin

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Human Protein Kinase D2 (PKD2) interaction partners

  1. PKD1 (show PKD1 Proteins) and PKD2 are susceptibility genes for familial intracranial aneurysms in a Japanese population.

  2. Novel PKD2 mutations in Chinese autosomal dominant polycystic kidney disease patients

  3. Two neutral missense PKD2 variants indentified in exon1 c.83G>C (p.R28P) and c.568G>A (p.A190T), which the former segregate with the mutation in affected relatives, and two new intronic and 3'UTR variants, c.1548+63C>T and c.*363delA.

  4. this study presents the cryo-EM structure of PKD2 in lipid bilayers at 3.0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into potential mechanisms for its activation.

  5. PCs expression and p53 (show TP53 Proteins) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.

  6. PKD2 and RSK1 (show RPS6KA1 Proteins) regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.

  7. The coiled-coil domain in the PC2 (show KRT6B Proteins) C-terminal forms a stable helix bundle regardless of the presence of Ca(2 (show CA2 Proteins)+).

  8. Results show that some of the previously reported missense or synonymous mutations in PKD2 gene caused altered pre-mRNA splicing.

  9. PKD2 is a core factor in the formation of this multiprotein complex at the TGN (show TG Proteins) that controls constitutive secretion of matrix metalloproteinase (show MMP20 Proteins) cargo.

  10. Human polycystin-2 transgene dose-dependently rescues autosomal-dominant polycystic kidney disease phenotypes in Pkd2 mutant mice

Mouse (Murine) Protein Kinase D2 (PKD2) interaction partners

  1. Our studies demonstrate that PKD1 (show PKD1 Proteins)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Proteins) effect on MVB secretory traffic.

  2. Results reveal that whereas protein kinase D1 (show PRKD1 Proteins) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.

  3. PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (show CD8A Proteins)(+) T cells that became effector cells.

  4. Protein kinase D2 promotes in vitro osteoclast differentiation and fusion

  5. A bioinformatic screen identified the serine-threonine kinase (show CDK4 Proteins) protein kinase D2 (PRKD2) as a potential effector of GABP in hematopoietic stem cells

  6. Transcriptional profiling reveals the full consequences of PKD2 loss and maps in detail the selective, but critical, function for PKD2 in signalling by alpha/beta mature TCR complexes in peripheral T-cells.

  7. PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC isoforms, in particular, PKCdelta (show PKCd Proteins) activate PKD2 in platelets.

  8. Data demonstrate that, unlike PKD1 (show PKD1 Proteins), PKD2 catalytic activity is dispensable for normal embryogenesis.

  9. PKD2, like PKD (show PRKD1 Proteins), facilitates mitogenesis in 3T3 cells

PKD2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PKD2

  • protein kinase D2 (PRKD2)
  • polycystic kidney disease 2 (autosomal dominant) (PKD2)
  • protein kinase D2 (Prkd2)
  • AI325941 protein
  • APKD2 protein
  • nPKC-D2 protein
  • Pc-2 protein
  • PC2 protein
  • PKD2 protein
  • PKD4 protein
  • PRKD2 protein
  • RGD1308054 protein
  • TRPP2 protein

Protein level used designations for Protein Kinase D2 Proteins (PKD2)

protein kinase D2 , serine/threonine-protein kinase D2-like , R48321 , autosomal dominant polycystic kidney disease type II protein , polycystin-2 , polycystwin , transient receptor potential cation channel, subfamily P, member 2 , serine/threonine-protein kinase D2 , nPKC-D2

468929 Pan troglodytes
782793 Bos taurus
100407181 Callithrix jacchus
100471375 Ailuropoda melanoleuca
5311 Homo sapiens
25865 Homo sapiens
101540 Mus musculus
292658 Rattus norvegicus
484427 Canis lupus familiaris
100517036 Sus scrofa
100355908 Oryctolagus cuniculus
100717067 Cavia porcellus
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