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anti-Human VIPR2 Antibodies:
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Human Polyclonal VIPR2 Primary Antibody for IF (p), IHC (p) - ABIN726170
Ruan, Yu, Xu, Zhang, Long, Shen: Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall. in Fitoterapia 2015
Human Monoclonal VIPR2 Primary Antibody for FACS, IHC (p) - ABIN1689323
Schulz, Mann, Novakhov, Piggins, Lupp: VPAC2 receptor expression in human normal and neoplastic tissues: evaluation of the novel MAB SP235. in Endocrine connections 2015
Human Polyclonal VIPR2 Primary Antibody for IHC (p) - ABIN4365553
Berger, Vistisen, Barrett, Hazlett: Effects of VIP on corneal reconstitution and homeostasis following Pseudomonas aeruginosa induced keratitis. in Investigative ophthalmology & visual science 2012
Study found a protective effect of PACAP-38 (show ADCYAP1 Antibodies) on oxidative stress damage in zebrafish hair cells, suggesting PACAP-38 (show ADCYAP1 Antibodies) ability to prevent hair cells from apoptosis. PACAP-38 (show ADCYAP1 Antibodies) treatment decreased the cleaved caspase-3 (show CASP3 Antibodies) level in the hair cells, but somewhat unexpectedly had no influence on p-38 MAPK (show MAPK1 Antibodies) pathway. PACAP-38 (show ADCYAP1 Antibodies) treatment also rescued H2O2-induced reduction in movement.
PACAP might play dual roles in regulating follicle growth and maturation through different receptors located in different compartments.
These results suggest that, in fish, PACAP and PAC1-R may play a role in brain development.
The temporal and spatial expression pattern of the ghrh-pacap1 (show ADCYAP1 Antibodies) transcript suggests that these hormones may modulate patterning during development.
zfPACAP38-2 is a potential ovarian factor that mediates gonadotropin actions in paracrine/autocrine manners, and its functional roles are likely, to some extent, related to the ovarian activin (show Actbeta Antibodies)/follistatin (show FST Antibodies) system.
Splice variants of pVPAC1-R are predominantly expressed in all tissues instead of the transcript encoding the full-length receptor, hinting that pVPAC2-R may play more important roles than pVPAC1-R in mediating VIP (show Vip Antibodies) and PACAP (show ADCYAP1 Antibodies) actions.
The 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male Han Chinese patients.
In vitro-polarized macrophages by GM-CSF (show CSF2 Antibodies) (GM-MO), with a proinflammatory profile, expressed higher levels of VIP (show Vip Antibodies) receptors, vasoactive intestinal polypeptide (show Vip Antibodies) receptors 1 and 2 (VPAC1 (show VIPR1 Antibodies) and VPAC2, respectively), than macrophages polarized by M-CSF (show CSF1 Antibodies) (M-MO) with anti-inflammatory activities. RA synovial macrophages, according to their GM-CSF (show CSF2 Antibodies)-like polarization state, expressed both VPAC1 (show VIPR1 Antibodies) and VPAC2.
Lower CpG methylation of VIPR2 in the saliva (show RAG1AP1 Antibodies) of children with ADHD.
The results reveal that more severe inflammation, based on high levels of IL-6 (show IL6 Antibodies), is associated with lower expression of VPAC1 (show VIPR1 Antibodies) and, conversely, with increased expression of VPAC2.
CD4 (show CD4 Antibodies)+ T cells in HIV infection show increased levels of expression of VPAC2
This study suggest that carriers of microduplication genotypes of VIPR2 are predisposed to SCZ in Han Chinese.
Monocytes from Sjogren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis.
Data indicate that VIP (show Vip Antibodies) and PACAP (show ADCYAP1 Antibodies) increased macrophage resistance to HIV-1 replication by inducing the synthesis of beta-chemokines CCL3 (show CCL3 Antibodies) and CCL5 (show CCL5 Antibodies) and IL-10 (show IL10 Antibodies) following preferential activation of the receptors VPAC2 and PAC1 (show ADCYAP1R1 Antibodies).
This is the first study to suggest a role of VIPR2 in the genetic susceptibility to high myopia. EGR1 (show EGR1 Antibodies), JUN (show JUN Antibodies), FOS and VIP (show Vip Antibodies) are unlikely to be important in predisposing humans to high myopia.
Genetic testing for VIPR2-LCR-associated inversions should be performed on available cohorts of psychiatric patients to evaluate their potential pathogenic role
PACAP (show ADCYAP1 Antibodies)/PAC1 (show ADCYAP1R1 Antibodies) signaling is important for light regulated behavior, VIP (show Vip Antibodies)/VPAC2 signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality.
Results demonstrate critical protective roles for PACAP (show ADCYAP1 Antibodies) and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool.
The results suggest that caveolin-1 (show CAV1 Antibodies) plays an important role in VPAC2 receptor internalization and desensitization.
Cumulus cells express PACAP (show ADCYAP1 Antibodies) and its receptors PAC1-R and VPAC2-R.
VPAC2R mRNA expression showed a nonsignificant tendency to increase on day 7 after ischemia induced by bilateral common carotid artery occlusion.
The loss of adrenal clock gene rhythm in the VPAC2 receptor knockout mice after transfer into constant darkness was accompanied by disappearance of rhythmicity in Star mRNA expression and serum corticosterone concentration.
Cyclophosphamide-induced cystitis significantly decreased VPAC2 receptor expression in the urothelium & detrusor of both WT and NGF-OE mice
The circadian clock, not ambient light level, regulates Vipr2 protein localization, since VAPC2R plays a role in signaling at all times of day.
Data support the notion that both VPAC1 (show VIPR1 Antibodies) and VPAC2 receptors are dynamically regulated by Ikaros (show IKZF1 Antibodies), a master transcriptional regulator for thymocyte differentiation, during early thymic development.
results support that decline in VIP (show Vip Antibodies)/VPAC local levels may influence survival/apoptosis intracellular set point in NOD acinar cells and their clearance, contributing to gland homeostasis loss in a model of Sjogren's syndrome
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.
vasoactive intestinal peptide receptor 2
, vasoactive intestinal polypeptide receptor type 2
, histidine-isoleucine receptor
, pituitary adenylate cyclase-activating peptide
, vasoactive intestinal polypeptide receptor 2
, vasoactive intestingal polypeptide receptor type 2
, VPAC2 receptor
, VIP-specific receptor
, gastric VPAC2 receptor
, vasoactive intestinal polypeptide receptor 2-like
, vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor 2
, PACAP type III receptor
, VIP and PACAP receptor 2
, helodermin-preferring VIP receptor
, pituitary adenylate cyclase-activating polypeptide type III receptor
, VIP receptor subtype 2
, vasopressive intestinal peptide receptor 2