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VHL Antibodies

(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
VHL antibody  (Center) VHL antibody  (Center) VHL antibody (Center) (ABIN2854928)

VHL Reactivity: Human, Mouse, Rat ICC, IF, IP, IHC (p), WB Host: Rabbit Polyclonal unconjugated

VHL antibody VHL antibody VHL antibody (ABIN1501712)

VHL Reactivity: Human IHC, IHC (p), WB Host: Mouse Monoclonal 1E1 unconjugated

VHL antibody  (AA 181-210) VHL antibody  (AA 181-210) VHL antibody (AA 181-210) (ABIN3029606)

VHL Reactivity: Human FACS, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated

VHL Antibodies by Grade

Find VHL Antibodies with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

VHL Antibodies by Reactivity

Find VHL Antibodies for a variety of species such as anti-Human VHL, anti-Mouse VHL, anti-Rat VHL. The species listed below are among those available. Click on a link to go to the corresponding products.

VHL Antibodies by Application

Find VHL Antibodies validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

VHL Antibodies by Host

Find VHL Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

VHL Antibodies by Binding Specificity

Find VHL Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

VHL Antibodies by Clonality

Find available monoclonal or polyclonal VHL Antibodies. Click on a link to go to the corresponding products.

VHL Antibodies by Clone

Find VHL Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

VHL Antibodies by Conjugate

Find VHL Antibodies with a specific conjugate such as Biotin, Alexa Fluor 488, Alexa Fluor 555. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular VHL Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ICC, IF, IP, IHC (p), WB
Validations
  • (1)
  • (8)
Cat. No. ABIN2854928
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, IHC (p), WB
Validations
  • (8)
Cat. No. ABIN1501712
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application FACS, IHC, ELISA, WB
Validations
  • (5)
Cat. No. ABIN3029606
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application IF, ELISA, WB
Validations
  • (4)
Cat. No. ABIN563371
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, EIA, IHC, WB
Validations
  • (3)
Cat. No. ABIN185675
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application FACS, IF/ICC, IHC, WB
Validations
  • (3)
Cat. No. ABIN2905637
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7189407
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (2)
Cat. No. ABIN6265976
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, IHC, WB
Validations
  • (2)
Cat. No. ABIN7271338
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN521329
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN521328
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (2)
Cat. No. ABIN2493850
Quantity 400 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (1)
Cat. No. ABIN872573
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application FACS, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN390463
Quantity 400 μL
Datasheet Datasheet
Reactivity Bat, Guinea Pig, Human, Monkey, Mouse, Pig, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6747472
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our VHL Antibodies

Li, Qu, Jin, Guo, Wang, Qi, Yang, Zhang, Li: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." in: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).

Gao, Wu, Xie, Li, Mao, Duan, Han, Han, Yu, Lu, Yang, Xu, Xia, Chen, Wang: "VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2." in: Nature communications, Vol. 8, pp. 15337, (2018) (PubMed).

Guo, Qi, Yang, Wang, Wang, Li, Li, Qu, Wang, Han: "Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts." in: Cell and tissue research, Vol. 367, Issue 2, pp. 197-211, (2017) (PubMed).

Liu, Cai, Hu, Mei, Zhang, Ouyang, Wang, Zhang, Xiao: "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." in: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25692-25705, (2017) (PubMed).

Lee, Frattini, Bansal, Castano, Sherman, Hutchinson, Bruce, Califano, Liu, Cardozo, Iavarone, Lasorella: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).

Alahari, Post, Caniggia: "Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta." in: Endocrinology, Vol. 156, Issue 8, pp. 3012-25, (2015) (PubMed).

Shao, Zhang, Yang, Qi, Zhang, Deng: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, (2015) (PubMed).

Du, Zhang, Zhang, Ouyang, Wang, Liu, Li, Ji, Liu, Xiao: "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1782-90, (2015) (PubMed).

Wang, Zhang, Ji, Liu, Ouyang, Xiao: "The von hippel-lindau protein suppresses androgen receptor activity." in: Molecular endocrinology (Baltimore, Md.), Vol. 28, Issue 2, pp. 239-48, (2015) (PubMed).

Xi, Gao, Han, Li, Feng, Zhang, Ji, Xiao, Zhang, Wei: "Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells." in: FEBS letters, Vol. 588, Issue 18, pp. 3390-4, (2014) (PubMed).

Aliases for VHL Antibodies

von Hippel-Lindau tumor suppressor (VHL) Antibodies
von Hippel-Lindau (Vhl) Antibodies
von Hippel-Lindau tumor suppressor (vhl) Antibodies
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) Antibodies
von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992) Antibodies
von Hippel-Lindau tumor suppressor (Vhl) Antibodies
BcDNA:RH61560 Antibodies
CG13221 Antibodies
d-VHL Antibodies
d-vhl Antibodies
Dmel\\CG13221 Antibodies
dmVHL Antibodies
DVhl Antibodies
Dvhl Antibodies
dVHL Antibodies
HRCA1 Antibodies
hrca1 Antibodies
pVHL Antibodies
RCA1 Antibodies
rca1 Antibodies
VHL Antibodies
vhl Antibodies
VHL1 Antibodies
vhl1 Antibodies
Vhlh Antibodies
zgc:158722 Antibodies
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