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High SATB1 expression is associated with glioblastoma.
These findings suggest SATB1 may play an important role in OSCC invasiveness and metastasis.
This paper provides evidence that SATB1 plays an oncogenic role in esophageal cancer by up-regulation of FN1 (show FN1 Proteins) and PDGFRB (show PDGFRB Proteins).
combination of the sequence-specific and nonspecific DNA-binding modes of SATB1 should be advantageous in a search for target loci during transcriptional regulation
revealed more than 170 NFAT (show NFATC1 Proteins)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Proteins) and NFATc2 (show NFAT1 Proteins) in T cells, such as Raptor (show RPTOR Proteins), CHEK1 (show CHEK1 Proteins), CREB1 (show CREB1 Proteins), RUNX1 (show RUNX1 Proteins), SATB1, Ikaros (show IKZF1 Proteins), and Helios (show ZNFN1A2 Proteins).
SATB1 interacts directly with OGG1 (show OGG1 Proteins), increases its binding to 8-oxoG-containing DNA, promotes Schiff base formation, and stimulates its glycosylase and apyrimidinic/apurinic lyase enzymatic activities.
High SATB1 expression in was detected in 48.3% of esophageal squamous cell carcinoma and 7.8% of normal esophagus tissues.
Silencing of special AT-rich sequence binding protein 1 inhibited the proliferation of KYSE450 and EC9706 cells which have a relatively high level of special AT-rich sequence binding protein 1, and the ability of migration and invasion of KYSE450 and EC9706 cells was distinctly suppressed.
Results suggest that SATB1 is activated to bind to chromatin at S/MARs after exposure to Abeta (show APP Proteins) 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta (show APP Proteins)-exposure.
Our results highlight the significance of SATB1 in intrahepatic cholangiocarcinoma
these results identify a role for Satb1 in the lineage choice between pluripotency and differentiation and further our understanding of early embryonic lineage segregation.
This study demonstrating that Satb1-dependent Cntn5 (show CNTN5 Proteins) expression in ON-OFF direction-selective ganglion cells leads to branch-specific homophilic interactions with interneurons.
we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development
this study shows that Satb1-dependent Treg cell-specific super-enhancers activation is crucial for Treg cell lineage specification in the thymus
Tumor-driven, unremitting expression of Satb1 in activated Zbtb46 (show ZNF340 Proteins)+ inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 (show LGALS1 Proteins) and IL-6 (show IL6 Proteins).
These results suggest that SATB1 plays an essential role in establishment of immune tolerance.
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
Fluorosed mouse ameloblasts have increased SATB1 retention and Galphaq (show GNAQ Proteins) activity.
The results indicated that the expression of SATB1 in both mRNA and protein levels was significantly decreased after cells transferred with siRNA sequence for 48 h, the proliferation of MF9 cells was significantly inhibited.
SATB1 binds to the ASE (show ARSE Proteins) and Rag promoters, facilitating inclusion of Rag2 (show RAG2 Proteins) in the chromatin hub and the loading of RNA polymerase II to both the Rag1 (show RAG1 Proteins) and Rag2 (show RAG2 Proteins) promoters.
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
SATB homeobox 1
, special AT-rich sequence binding protein 1
, AT-rich binding protein-1
, DNA-binding protein SATB1-like
, DNA-binding protein SATB1
, special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
, special AT-rich sequence-binding protein 1