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SARS-CoV-2 Spike S1 Proteins

(SARS-CoV-2 Spike S1)

attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

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SARS-CoV-2 Spike S1 Protein (His tag) (ABIN6952427)

Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func, SDS

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recommended

SARS-CoV-2 Spike S1 Protein (RBD) (His-SUMOstar Tag) (ABIN6953166)

Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: Yeast Recombinant Greater than 85 % as determined by SDS-PAGE.

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recommended

SARS-CoV-2 Spike S1 Protein (RBD) (His tag,MYC tag) (ABIN6953168)

Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: Mammalian Cells Recombinant Greater than 90 % as determined by SDS-PAGE.

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SARS-CoV-2 Spike S1 Proteins by Origin

Find SARS-CoV-2 Spike S1 Proteins for a variety of species such as anti-SARS Coronavirus-2 (SARS-CoV-2) SARS-CoV-2 Spike S1, anti-SARS CoV-2 Omicron SARS-CoV-2 Spike S1, anti-SARS Coronavirus (SARS-CoV) SARS-CoV-2 Spike S1. The species listed below are among those available. Click on a link to go to the corresponding products.

SARS-CoV-2 Spike S1 Proteins by Source

Find SARS-CoV-2 Spike S1 Proteins with a specific Source. The Source listed below are among those available. Click on a link to go to the corresponding products.

SARS-CoV-2 Spike S1 Proteins by Protein Type

Find SARS-CoV-2 Spike S1 Proteins with a specific Protein Type. The Protein Type listed below are among those available. Click on a link to go to the corresponding products.

SARS-CoV-2 Spike S1 Proteins by Application

Find SARS-CoV-2 Spike S1 Proteins validated for a specific application such as ELISA, SDS, WB, Func. Some of the available applications are listed below. Click on a link to go to the corresponding products.

SARS-CoV-2 Spike S1 Proteins by Biological Activity

Find SARS-CoV-2 Spike S1 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular SARS-CoV-2 Spike S1 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

SARS-CoV-2 Spike S1 Protein (His tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952427

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD) (His-SUMOstar Tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source Yeast

Validations

Cat. No. ABIN6953166

Quantity 1 mg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD) (His tag,MYC tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source Mammalian Cells

Validations

Cat. No. ABIN6953168

Quantity 1 mg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD) (His tag,AVI tag,Biotin)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952456

Quantity 200 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (B.1.1.529 - Omicron) (His tag)

Reactivity SARS CoV-2 Omicron, SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN7274393

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (Fc Tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952624

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD) (His tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952628

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD, W436R) (His tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952632

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD) (Fc Tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952462

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (D614G) (His tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6953175

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (B.1.351 - beta, RBD) (His tag)

Reactivity SARS CoV-2 Beta, SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN7013274

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD, V483A) (His tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6953173

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (RBD, V367F) (His tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952630

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (R408I, RBD) (His tag)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952633

Quantity 100 μg

Datasheet Datasheet

SARS-CoV-2 Spike S1 Protein (His tag,AVI tag,Biotin)

Reactivity SARS Coronavirus-2 (SARS-CoV-2)

Source HEK-293 Cells

Validations

Cat. No. ABIN6952457

Quantity 200 μg

Datasheet Datasheet

Latest Publications for our SARS-CoV-2 Spike S1 Proteins

Erickson, Logsdon, Rhea, Hansen, Holden, Banks, Smith, German, Farr, Morley, Weaver, Hirsch, Kovac, Kontsekova, Baumann, Omer, Raber: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." in: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).

Kaneko, Satta, Komuro, Muthukrishnan, Kakarla, Guo, An, Elahi, Kornblum, Liebeskind, Hsiai, Hinman: "Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection." in: Stroke, Vol. 52, Issue 1, pp. 260-270, (2021) (PubMed).

Sasisekharan, Pentakota, Jayaraman, Tharakaraman, Wogan, Narayanasami: "Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 5, (2021) (PubMed).

Dogan, Kozhaya, Placek, Gunter, Yigit, Hardy, Plassmeyer, Coatney, Lillard, Bukhari, Kleinberg, Hayes, Arditi, Klapper, Merin, Liang, Gupta, Alpan, Unutmaz: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." in: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).

Narang, James, Balmer, Wilson: "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction." in: Journal of the American Society for Mass Spectrometry, (2021) (PubMed).

Fiedler, Piziorska, Denninger, Morgunov, Ilsley, Malik, Schneider, Devenish, Meisl, Kosmoliaptsis, Aguzzi, Fiegler, Knowles: "Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum." in: ACS infectious diseases, (2021) (PubMed).

Lucas, Klein, Sundaram, Liu, Wong, Silva, Mao, Oh, Mohanty, Huang, Tokuyama, Lu, Venkataraman, Park, Israelow, Vogels, Muenker, Chang, Casanovas-Massana, Moore, Zell, Fournier, Wyllie, Campbell, Lee et al.: "Delayed production of neutralizing antibodies correlates with fatal COVID-19. ..." in: Nature medicine, (2021) (PubMed).

Song, Bartley, Chow, Ngo, Jiang, Zamecnik, Dandekar, Loudermilk, Dai, Liu, Sunshine, Liu, Wu, Hawes, Alvarenga, Huynh, McAlpine, Rahman, Geng, Chiarella, Goldman-Israelow, Vogels, Grubaugh et al.: "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. ..." in: Cell reports. Medicine, pp. 100288, (2021) (PubMed).

Guo, Huang, Zhang, Yao, Zhou, Shen, Shen, Li, Li, Zhang, Chen, Chen, Wu, Fu, Zeng, Feng, Pi, Wang, Zhou, Lu, Li, Fang, Lu, Hu, Wang, Zhang, Gao, Adrian, Wang, Yu, Peng, Gabibov, Min, Wang, Huang et al.: "A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. ..." in: Nature communications, Vol. 12, Issue 1, pp. 2623, (2021) (PubMed).

Maritz, Woudberg, Bennett, Soares, Lapierre, Devine, Kimberg, Bouic: "Validation of high-throughput, semiquantitative solid phase SARS coronavirus-2 serology assays in serum and dried blood spot matrices." in: Bioanalysis, (2021) (PubMed).

Aliases for SARS-CoV-2 Spike S1 Proteins

Surface Glycoprotein (S) Proteins
E2 Proteins

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SARS-CoV-2 Spike S1 Proteins by Origin

SARS-CoV-2 Spike S1 Proteins by Source

SARS-CoV-2 Spike S1 Proteins by Protein Type

SARS-CoV-2 Spike S1 Proteins by Application

SARS-CoV-2 Spike S1 Proteins by Biological Activity

Popular SARS-CoV-2 Spike S1 Proteins

Latest Publications for our SARS-CoV-2 Spike S1 Proteins

Aliases for SARS-CoV-2 Spike S1 Proteins

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