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the expression of claudin-5 (show CLDN5 Proteins) and claudin-9 was down-regulated while the expression of claudin-8 (show CLDN8 Proteins) was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues.
CLDN9 may be an important biomarker for invasive pituitary oncocytomas.
Although claudin-6 (show CLDN6 Proteins) and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 (show CLDN6 Proteins) and claudin-9.
Increased expression of claudin-6 (show CLDN6 Proteins), claudin-7 (show CLDN7 Proteins), or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line.
Mouse studies suggest that claudin-9 deficiency may cause hearing loss not only in mice but also in humans.
Residues N38 and V45 in the first extracellular loop (EL1 (show EPB41 Proteins)) of CLDN9 are necessary for HCV entry.
claudin-6 (show CLDN6 Proteins) and claudin-9 expressed in CD81 (show CD81 Proteins)+ cells also enable the entry of HCV pseudoparticles derived from six of the major genotypes.
CLDN9, clustered with CLDN6 (show CLDN6 Proteins) at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
These results suggest an essential role for claudin-9 in promoting lung cancer metastasis
Claudin-9 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.
developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13
Claudin-9 is required for the preservation of sensory cells in the hearing organ.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness.