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Browse our anti-Neurofibromin 2 (NF2) Antibodies

Full name:
anti-Neurofibromin 2 Antibodies (NF2)
On www.antibodies-online.com are 162 Neurofibromin 2 (NF2) Antibodies from 25 different suppliers available. Additionally we are shipping Neurofibromin 2 Kits (14) and Neurofibromin 2 Proteins (7) and many more products for this protein. A total of 195 Neurofibromin 2 products are currently listed.
Synonyms:
ACN, BANF, merlin, NF2, NF2a, SCH, zgc:194620, zgc:194631

Most Popular Reactivities for anti-Neurofibromin 2 (NF2) Antibodies

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Top referenced anti-Neurofibromin 2 Antibodies

  1. Human Polyclonal NF2 Primary Antibody for IHC (p), WB - ABIN197520 : Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for ABIN197520

  2. Human Polyclonal NF2 Primary Antibody for IF, WB - ABIN197028 : Yang, Hinds: Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. in Cancer research 2006 (PubMed)
    Show all 4 references for ABIN197028

  3. Human Polyclonal NF2 Primary Antibody for IHC, ELISA - ABIN1532019 : Yu, Zeidel, Hill: Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN1532019

  4. Human Polyclonal NF2 Primary Antibody for EIA, WB - ABIN117953 : Gutmann, Wright, Geist, Snider: Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. in Human molecular genetics 1995 (PubMed)
    Show all 2 references for ABIN117953

  5. Human Polyclonal NF2 Primary Antibody for IP, IHC - ABIN104130 : Wang, Lu, Tang, Wang, Wu: The phosphorylation status of merlin in sporadic vestibular Schwannomas. in Molecular and cellular biochemistry 2009 (PubMed)
    Show all 2 references for ABIN104130

  6. Human Polyclonal NF2 Primary Antibody for ELISA, WB - ABIN1533058 : Trofatter, MacCollin, Rutter, Murrell, Duyao, Parry, Eldridge, Kley, Menon, Pulaski: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. in Cell 1993 (PubMed)
    Show all 2 references for ABIN1533058

  7. Zebrafish (Danio rerio) Polyclonal NF2 Primary Antibody for EIA, IHC (p) - ABIN401528 : Sadler, Amsterdam, Soroka, Boyer, Hopkins: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. in Development (Cambridge, England) 2005 (PubMed)

  8. Human Polyclonal NF2 Primary Antibody for EIA, WB - ABIN453191 : James, Han, Polizzano, Plotkin, Manning, Stemmer-Rachamimov, Gusella, Ramesh: NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. in Molecular and cellular biology 2009 (PubMed)

More Antibodies against Neurofibromin 2 Interaction Partners

Zebrafish Neurofibromin 2 (NF2) interaction partners

  1. Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct

Mouse (Murine) Neurofibromin 2 (NF2) interaction partners

  1. co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by Nf2 loss, which can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap (show YAP1 Antibodies).

  2. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP (show YAP1 Antibodies) signaling activity.

  3. NF2 is activated by oxidative stress in cardiomyocytes and myocardium and facilitates apoptosis.

  4. loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (show NGFR Antibodies)) expression.

  5. Loss of Nf2 and Cdkn2a (show CDKN2A Antibodies)/b have synergistic effects with PDGF-B (show PDGFB Antibodies) overexpression promoting meningioma malignant transformation.

  6. Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation

  7. Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.

  8. Merlin and Ezrin (show EZR Antibodies) are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (show EGFR Antibodies).

  9. The study describe a novel NF2 mouse model recapitulating schwannoma phenotypes found in human patients where tumors develop in the cranial nerve VIII (show COX8A Antibodies) and/or the spinal roots.

  10. Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2 (show ERBB2 Antibodies)-dependent manner.

Human Neurofibromin 2 (NF2) interaction partners

  1. co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by Nf2 loss, which can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap (show YAP1 Antibodies).

  2. Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2), LATS2 (show LATS2 Antibodies) (large tumor suppressor (show LATS1 Antibodies) kinase 2), and YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) (nuclear translocation of complex of Yes-associated protein [YAP (show YAP1 Antibodies)] with transcriptional coactivator with PDZ-binding motif (show WWTR1 Antibodies) [TAZ (show TAZ Antibodies)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.

  3. The mortality of patients with NF2 diagnosed in more recent decades was lower than that of patients diagnosed earlier.

  4. AMOTL1 (show AMOTL1 Antibodies) Promotes Breast Cancer Progression and Is Antagonized by Merlin

  5. homozygous deletions in CDKN2A (show CDKN2A Antibodies) and hemizygous loss of NF2 as detected by fluorescence in situ hybridization would confer a poor clinical outcome and may guide future treatment decisions for patients with peritoneal mesothelioma.

  6. NF2/merlin inactivation augments mutant RAS signaling by promoting YAP (show YAP1 Antibodies)/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK (show MAPK1 Antibodies) output and increased sensitivity to MEK (show MAP2K1 Antibodies) inhibitors.

  7. Loss of Nf2 and Cdkn2a (show CDKN2A Antibodies)/b have synergistic effects with PDGF-B (show PDGFB Antibodies) overexpression promoting meningioma malignant transformation.

  8. we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP (show YAP1 Antibodies)-dependent induction of CYR61/CCN1 (show CYR61 Antibodies) and miR (show MLXIP Antibodies)-296-3p.

  9. angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling

  10. (Delta2-4)Merlin variant disrupts the normal function of Merlin and promotes hepatocellular carcinoma metastasis.

Neurofibromin 2 (NF2) Antigen Profile

Antigen Summary

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Alternative names and synonyms associated with Neurofibromin 2 (NF2)

  • neurofibromin 2b (merlin) (nf2b) antibody
  • neurofibromin 2 (bilateral acoustic neuroma) (NF2) antibody
  • neurofibromin 2 (merlin) (NF2) antibody
  • neurofibromin 2 (NF2) antibody
  • neurofibromin 2 (LOC100357691) antibody
  • merlin-like (LOC417537) antibody
  • neurofibromatosis 2 (Nf2) antibody
  • neurofibromin 2 (merlin) (Nf2) antibody
  • neurofibromin 2a (merlin) (nf2a) antibody
  • ACN antibody
  • BANF antibody
  • merlin antibody
  • NF2 antibody
  • NF2a antibody
  • SCH antibody
  • zgc:194620 antibody
  • zgc:194631 antibody

Protein level used designations for anti-Neurofibromin 2 (NF2) Antibodies

neurofibromin 2 (bilateral acoustic neuroma) , merlin , neurofibromatosis 2 , neurofibromin 2 , moesin-ezrin-radixin-like protein , neurofibromin-2 , schwannomin , moesin-ezrin-radixin like , moesin-ezrin-radizin-like protein , schwannomerlin

GENE ID SPECIES
405887 Danio rerio
395158 Gallus gallus
100058977 Equus caballus
100329097 Saccoglossus kowalevskii
100357691 Oryctolagus cuniculus
417537 Gallus gallus
18016 Mus musculus
4771 Homo sapiens
25744 Rattus norvegicus
477535 Canis lupus familiaris
100520699 Sus scrofa
540479 Bos taurus
561184 Danio rerio
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