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Merlin antibody (AA 477-576)

NF2 Reactivity: Human WB, IF, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6144548
  • Target See all Merlin (NF2) Antibodies
    Merlin (NF2) (Neurofibromin 2 (NF2))
    Binding Specificity
    • 28
    • 15
    • 9
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 477-576
    Reactivity
    • 76
    • 65
    • 53
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human
    Host
    • 87
    • 4
    • 1
    Rabbit
    Clonality
    • 89
    • 3
    Polyclonal
    Conjugate
    • 46
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This Merlin antibody is un-conjugated
    Application
    • 70
    • 30
    • 27
    • 26
    • 19
    • 16
    • 11
    • 10
    • 6
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Sequence
    TKPTYPPMNP IPAPLPPDIP SFNLIGDSLS FDFKDTDMKR LSMEIEKEKV EYMEKSKHLQ EQLNELKTEI EALKLKERET ALDILHNENS DRGGSSKHNT
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 477-576 of human NF2 (NP_000259.1).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Merlin (NF2) (Neurofibromin 2 (NF2))
    Alternative Name
    NF2 (NF2 Products)
    Synonyms
    ACN antibody, BANF antibody, SCH antibody, NF2 antibody, merlin antibody, zgc:194620 antibody, zgc:194631 antibody, NF2a antibody, nf2 antibody, neurofibromin 2 antibody, neurofibromin 2a (merlin) antibody, neurofibromin 2b (merlin) antibody, neurofibromin 2 (merlin) S homeolog antibody, NF2 antibody, Nf2 antibody, nf2a antibody, nf2b antibody, nf2.S antibody
    Background
    This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.,NF2,ACN,BANF,SCH,merlin,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Hippo Signaling Pathway,Neuroscience,NF2
    Molecular Weight
    19-30 kDa/59-72 kDa
    Gene ID
    4771
    UniProt
    P35240
    Pathways
    Cell-Cell Junction Organization
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