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Study provides evidence that occludin contributes to the regulation of size-reductive proliferation and epithelial cell maturation in a phosphorylation-dependent manner.
Report shows that silencing MARCH3 (show MARCH3 Proteins) protects the endothelial barrier and upregulates OCLN in MARCH3 (show MARCH3 Proteins)-depleted cells. MARCH3 (show MARCH3 Proteins) silencing results in the strengthening of cell-cell contacts and inactivates FoxO1 (show FOXO1 Proteins).
STAT3 activation downregulates the ZO-1 and occludin levels and increases the endothelial permeability through the induction of VEGF production in retinal endothelial cells.
Downregulation of OCLN is associated with clear cell renal cell carcinoma (show MOK Proteins).
These data suggest that the Rho/ROCK signaling pathway is involved in HIV-1 Tat (show TAT Proteins)-mediated changes in occludin, RAGE (show AGER Proteins), and LRP1 (show LRP1 Proteins) in human cerebral microvascular endothelial cells cells.
OCLN is essential for HCV infection of human hepatic cells.
OCLN and ZO1 (show TJP1 Proteins) levels appear to be early prognostic markers in patients suffering from sepsis.
autotypic tight junctions molecular composition, like claudin-1 (show CLDN7 Proteins) and occludin expression could influence the demyelinating process by altering the permeability of the blood-nerve barrier.
Occludin expression has a clear relationship with bone metastasis in human cancer.
This is report of a family of Indian origin with two affected sibs and segregation of a homozygous novel OCLN mutation in the exon 3(NG_028291.1(OCLN_v001):c.252delC).
ADMA has potent adverse effects on cell proliferation, intracellular ROS (show ROS1 Proteins) generation, cell permeability, levels of ICAM-1 (show ICAM1 Proteins), and the tight-junction protein occludin
the presence of occludin at the membrane is dependent in part on calcium-sensitive signaling cascades
cyclic strain modulates both the expression and phosphorylation state of occludin and ZO-1 (show TJP1 Proteins) in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity
These data demonstrate a novel mechanism of VEGF (show VEGFA Proteins)-induced occludin phosphorylation and ubiquitination that contributes to TJ trafficking and subsequent vascular permeability.
Tricellulin (show MARVELD2 Proteins) is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin loss at 2-cell contacts in vivo and in vitro.
These findings provide evidence for occludin playing a role in the invasion of Toxoplasma gondii in small intestinal epithelial cells.
occludin deficiency increases susceptibility to ethanol-induced colonic mucosal barrier dysfunction and liver damage in mice.
PHD3 (show EGLN3 Proteins) protects intestinal epithelial barrier function and reveal a hydroxylase-independent function of PHD3 (show EGLN3 Proteins) in stabilizing occludin
Zonula occludens-1 (show TJP1 Proteins), occludin and E-cadherin (show CDH1 Proteins) expression and organization in salivary glands
Our study demonstrates spatiotemporal alterations in occludin mRNA- and protein-expression, indicating that Cx43 (show GJA1 Proteins) might act as a regulator for blood-testis-barrier
Occludin and Claudin-1 (show CLDN1 Proteins) expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis.
Hypoxic induction of CAV1 (show CAV1 Proteins) in the colon was essential for intestinal barrier integrity by regulating occludin expression.
Activation of RhoA (show RHOA Proteins)/ROCK1 (show ROCK1 Proteins) by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin/ZO-1 (show TJP1 Proteins), which can be corrected by simvastatin.
ZO-1 (show TJP1 Proteins) and occludin are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin at the blastocyst stage.
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
, tight junction protein occludin TM4 minus
, thiopurine methyltransferase
, tight junction protein occludin
, tight-junction protein
, occludin b